Grundinformationen
- CAS
127-48-0- Standard-SMILES
CN1C(=O)OC(C)(C)C1=O- InChIKey
IRYJRGCIQBGHIV-UHFFFAOYSA-N- Summenformel
- C6H9NO3
- Durchschnittliche Molmasse
- 143,14 g/mol
- Monoisotopische Masse
- 143,05824315
Überblick
Trimethadione can cause developmental toxicity according to state or federal government labeling requirements.
Namen und Bezeichner
- Bevorzugter Name
- Trimethadione
- IUPAC
- 3,5,5-trimethyl-1,3-oxazolidine-2,4-dione
- Lokaler Name
- Trimethadion
- Englischer Name
- 3,5,5-Trimethyloxazolidine-2,4-dione
- Summenformel
- C6H9NO3
- Molmasse
- 143.14
Namen und Synonyme
trimethadione127-48-0TridioneTroxidoneTrimethadionAbsentolEpidioneTrimetadioneMinoaleviatinPtimalConvenixaPetimalin
Weitere Namen anzeigen
a2297A 2297PitmalEpidoneEtydionPetidon
AbsetilEpixalPetilepEdionTridone3,5,5-Trimethyl-1,3-oxazolidine-2,4-dioneTrimetadionaTrimethadionum
Datenbank-Bezeichner
- CAS
127-48-0- PubChem CID
- 5576
- DTXSID
DTXSID9021396- ChEMBL
CHEMBL695- ChEBI
CHEBI:9727- UNII
- R7GV3H6FQ4
- EC Number
- 204-845-8
- Nikkaji
- J2.519D
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 0,3
- Polarare Oberfläche (TPSA)
- 46,6 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 3
- Frei drehbare Bindungen
- 0
- Schwere Atome
- 10
- Formalladung
- 0
- Komplexität
- 197
Experimentelle und physikochemische Eigenschaften
Drugs
Pharmaceuticals -> Listed in ZINC15
Pharmaceuticals -> Antiepileptics
SpringerMaterials PropertiesCrystal structure
LogP-0.37
Solubility
2.12e+02 g/L
<0.3 [ug/mL] (The mean of the results at pH 7.4)
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Melting Point46 °C
Physical DescriptionSolid
Physikochemische Eigenschaften
- Schmelzpunkt
- 45 · 45-46°C
- Siedepunkt
- 78 · 78-80°C 5mm
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Danger
H312 (87%): Harmful in contact with skin [Warning Acute toxicity, dermal]
P203, P261, P271, P280, P302+P352, P304+P340, P317, P318, P321, P362+P364, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 46 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Regulatory Information
Hazard Traits - Developmental Toxicity
2,4-Oxazolidinedione, 3,5,5-trimethyl-: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and CategoriesAcute Tox. 4 (87%)
Toxikologische Informationen
Health EffectsMay cause a potentially dangerous rash that may develop into Stevens Johnson syndrome, an extremely rare but potentially fatal skin disease.
Toxicity Summary
Dione anticonvulsants reduce T-type calcium currents in thalamic neurons, including thalamic relay neurons. It does so via the inhibition of voltage dependent T-type calcium channels. This raises the threshold for repetitive activity in the thalamus, and inhibits corticothalamic transmission. Thus, the abnormal thalamocortical rhythmicity, which is thought to underlie the 3-Hz spike-and-wave discharge seen on electroencephalogram(EEG) with absence seizures, is dampened.
Signs and SymptomsSymptoms of overdose include clumsiness or unsteadiness, coma, dizziness (severe), drowsiness (severe), nausea (severe), and problems with vision.
Chemie und Industrie
Pharmakologische Informationen
ATC Code
N - Nervous system
QN - Nervous system
Protein Binding90%
Pharmacodynamics
Paramethadione and trimethadione are anticonvulsants indicated in the control of absence (petit mal) seizures that are refractory to treatment with other medications. Dione anticonvulsants are used in the treatment of epilepsy. They act on the central nervous system (CNS) to reduce the number of seizures.
Mechanism of Action
Dione anticonvulsants reduce T-type calcium currents in thalamic neurons, including thalamic relay neurons. It does so via the inhibition of voltage dependent T-type calcium channels. This raises the threshold for repetitive activity in the thalamus, and inhibits corticothalamic transmission. Thus, the abnormal thalamocortical rhythmicity, which is thought to underlie the 3-Hz spike-and-wave discharge seen on electroencephalogram(EEG) with absence seizures, is dampened.
Metabolism/MetabolitesTrimethadione has known human metabolites that include Dimethadione.
FDA Pharmacological Classification
R7GV3H6FQ4
TRIMETHADIONE
Established Pharmacologic Class [EPC] - Anti-epileptic Agent
Physiologic Effects [PE] - Decreased Central Nervous System Disorganized Electrical Activity
Trimethadione is an Anti-epileptic Agent. The physiologic effect of trimethadione is by means of Decreased Central Nervous System Disorganized Electrical Activity.
MeSH Pharmacological ClassificationDrugs used to prevent SEIZURES or reduce their severity.
Cellular LocationsMembrane
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