HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Desacetylravidomycin
AY-26623 · WK-6326-M7 · Deacetylravidomycin · Antibiotic AY-26623 · desacetylravidomycin · O-Deacetylravidomycin · 4-[3-(Dimethylamino)-3,6-dideoxy-α-D-altropyranosyl]-8-ethenyl-1-hydroxy-10,12-dimethoxy-6H-benzo[d]naphtho[1,2-b]pyran-6-one · 6H-Benzo[d]naphtho[1,2-b]pyran-6-one, 4-[3,6-dideoxy-3-(dimethylamino)-β-D-galactopyranosyl]-8-ethenyl-1-hydroxy-10,12-dimethoxy-
Identifikatoren & physikalische Daten
| CAS No. | 88580-27-2 |
|---|---|
| Summenformel | C29H31NO8 |
| Durchschnittliche Molmasse | 521,6 g/mol |
| Monoisotopische Masse | 521,20496695 g/mol |
| SMILES | C=Cc1cc(OC)c2c(c1)c(=O)oc1c2cc(OC)c2c(O)ccc([C@H]3O[C@H](C)[C@@H](O)[C@@H](N(C)C)[C@@H]3O)c21 |
| InChIKey | ZHXCTIMNNKVMJM-JSPLCZCHSA-N |
| PubChem CID | 55833 |
| DTXSID | DTXSID401008241 |
Chemische & physikalische Eigenschaften
| XLogP | 3,4 |
|---|---|
| Polarare Oberfläche (TPSA) | 118 |
| H-Brücken-Donoren | 3 |
| H-Brücken-Akzeptoren | 9 |
| Frei drehbare Bindungen | 5 |
| Schwere Atome | 38 |
| Formalladung | 0 |
| Komplexität | 870 |
| Siedepunkt | 791.956±60.00 °C(Press: 760.00 Torr)(predicted) |
| Dichte | 1.404±0.10 g/cm3(Temp: 25 °CPress: 760 Torr)(predicted) |
| Lagerbedingungen | Store at -20°C |
| Löslichkeit | Soluble in DMSO |
| Aggregatzustand | A solid |
| pKa (Säurekonstante) | 8.522±0.20(predicted) |
Anwendungen & Verwendung
Verwenden
O-Deacetylravidomycin is the more active and stable analogue of the ravidomycin complex produced by Streptomyces ravidus. The metabolite shows potent, light-dependent antitumour activity. O-Deacetylravidomycin, like the related gilvocarcins and chrysomycins, is thought to act as a topoisomerase II inhibitor.