Diphosphorsäuretetrakis-(phenylmethyl)ester
TETRABENZYL DIPHOSPHATE · PYROPHOSPHORIC ACID TETRABENZYL ESTER · C2gH2gO7P2 · TetrabenzyL · Bis(phenylmethox · Benzyl Pyrophosphate · Tetracyl pyrophosphate · Tetrabenzyl yrophosphate
Identifikatoren & physikalische Daten
| CAS No. | 990-91-0 |
|---|---|
| Summenformel | C28H28O7P2 |
| Durchschnittliche Molmasse | 538,5 g/mol |
| Monoisotopische Masse | 538,13102722 g/mol |
| SMILES | O=P(OCc1ccccc1)(OCc1ccccc1)OP(=O)(OCc1ccccc1)OCc1ccccc1 |
| InChIKey | NSBNXCZCLRBQTA-UHFFFAOYSA-N |
| PubChem CID | 563183 |
| EC No. | 628-817-3 |
| DTXSID | DTXSID00340276 |
| Lokaler Name | Diphosphorsäuretetrakis-(phenylmethyl)ester |
Chemische & physikalische Eigenschaften
| XLogP | 4,9 |
|---|---|
| Polarare Oberfläche (TPSA) | 80,3 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 7 |
| Frei drehbare Bindungen | 14 |
| Schwere Atome | 37 |
| Formalladung | 0 |
| Komplexität | 612 |
| Schmelzpunkt | 63-66 °C (lit.) |
| Siedepunkt | 601.6±55.0 °C(Predicted) |
| Dichte | 1.289±0.06 g/cm3(Predicted) |
| Dampfdruck | 0.001Pa at 140℃ |
| Lagerbedingungen | -20°C |
| Löslichkeit | Chloroform (Slightly), Methanol (Slightly)Slightly soluble in water. |
| Aggregatzustand | Powder or Crystalline Powder |
| Farbe | White to off-white |
| BRN | 2068292 |
| InChI | InChI=1S/C28H28O7P2/c29-36(31-21-25-13-5-1-6-14-25,32-22-26-15-7-2-8-16-26)35-37(30,33-23-27-17-9-3-10-18-27)34-24-28-19-11-4-12-20-28/h1-20H,21-24H2 |
| InChIKey | NSBNXCZCLRBQTA-UHFFFAOYSA-N |
| SMILES | P(=O)(OCC1C=CC=CC=1)(OCC1C=CC=CC=1)OP(=O)(OCC1C=CC=CC=1)OCC1C=CC=CC=1 |
| CAS Datenbank | 990-91-0(CAS DataBase Reference) |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH314 (96.2%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]P260, P264, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P363, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 52 reports by companies from 5 notifications to the ECHA C&L Inventory.Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
|---|---|
| Regulatorische Informationen | Status: Active Update: 28-07-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/19753Status: Active Update: 03-02-2017 https://echa.europa.eu/registration-dossier/-/registered-dossier/18954 |
| Hazard Classes and Categories | Skin Corr. 1B (96.2%) |
| F | 10-21 |
| Wassergefährdungsklasse (WGK) | 3 |
| UN-Transportnummer | UN 3261 8/PG 2 |
| Zollcode | 29209090 |
| R-Sätze (R) | 34 |
| Gefahrensymbole | C |
| Sicherheitshinweise (S) | 26-36/37/39-45 |
| Gefahrenklasse | 8 |
| Verpackungsgruppe | II |
Anwendungen & Verwendung
Verwenden
Tetrabenzyl pyrophosphate is used in the preparation of phosphoryl derivatives of shikimic acid in the presence of LDA. It is used in the preparation of dibenzyl phosphoro fluoridate in the presence of cesium fluoride as a catalyst. It is also used as a precursor in pharmaceuticals and involved in the phosphorylation of inositol derivatives.
Herstellung & Synthese
synthetische
The production of tetrabenzyl pyrophosphate by the action of acyl chlorides on dibenzyl hydrogen phosphate, and a novel reaction of tetraphenyl pyrophosphate.Preparation of Tetrabenzyl Pyrophosphate: A flask fitted with a nitrogen inlet, overhead stirrer, teflon-coated thermocouple probe, and pressure-equalizing addition funnel was charged with 350 milliliters of dry (water content ≦50 μg/mL), peroxide-free tetrahydrofuran, followed by 50.0 grams (174 millimoles) of dibenzylphosphoric acid (DBP), and the resulting mixture was stirred until the solid dissolved (about 10-15 minutes). A solution of 18.9 grams (91.6 millimoles) of dicyclohexylcarbodiimide (DCC) in 215 milliliters of THF was added from the addition funnel to a stirred, cooled (water-bath) solution of DBP at a rate to maintain the temperature at about 20°-25° C. The reaction is slightly exothermic and the addition took about 30 minutes. Within minutes, a precipitate of dicyclohexylurea formed in the mixture. Stirring was continued for about 2 hours at 20°-25° C. The reaction was monitored by HPLC assay using VYDAC C-18 (300A, 4.6×250 mm) column with water (0.02M KH2PO4) acetonitrile as eluent. The reaction was complete in about 1 hour (assay showing <2 percent unreacted DBP). The mixture was then filtered while excluding moisture to remove dicyclohexylurea. The filter cake was washed with two 25 milliliter portions of THF. The solution when assayed by HPLC showed 45.9 grams (98 percent) yield of tetrabenzyl pyrophosphate (TBPP) in 620 milliliters of THF (0.137M). The filtrate was then stored at 0° C. with exclusion of moisture until the next step.