HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Ufenamate
BUTYL FLUFENAMATE · Etofenamate EP Impurity B · Flufenamic acid butyl ester · HF-264 · Combec · Fenazol · ufemate · Butyl N
Identifikatoren & physikalische Daten
| CAS No. | 67330-25-0 |
|---|---|
| Summenformel | C18H18F3NO2 |
| Durchschnittliche Molmasse | 337,3 g/mol |
| Monoisotopische Masse | 337,12896348 g/mol |
| SMILES | CCCCOC(=O)c1ccccc1Nc1cccc(C(F)(F)F)c1 |
| InChIKey | JDLSRXWHEBFHNC-UHFFFAOYSA-N |
| PubChem CID | 5632 |
| ChEMBL | CHEMBL2105605 |
| ChEBI | CHEBI:32276 |
| EC No. | 614-050-1 |
| DTXSID | DTXSID30867269 |
Chemische & physikalische Eigenschaften
| XLogP | 6,8 |
|---|---|
| Polarare Oberfläche (TPSA) | 38,3 |
| H-Brücken-Donoren | 1 |
| H-Brücken-Akzeptoren | 6 |
| Frei drehbare Bindungen | 7 |
| Schwere Atome | 24 |
| Formalladung | 0 |
| Komplexität | 400 |
| PFAS | PFAS -> PFAS identified in REACH Regulation EC No. 1272/2008 |
| Arzneimittel | Pharmaceuticals -> Musculo-skeletal system -> Anti-inflammatory and antirheumatic products |
| Siedepunkt | 170°C/1mmHg(lit.) |
| Dichte | 1.2230 (estimate) |
| Dampfdruck | 0Pa at 25℃ |
| Brechungsindex | 1.5530 to 1.5570 |
| Lagerbedingungen | Keep in dark place,Inert atmosphere,Room temperature |
| Löslichkeit | DMSO: ≥ 44 mg/mL (130.43 mM) |
| Aggregatzustand | clear liquid |
| pKa (Säurekonstante) | -2.36±0.50(Predicted) |
| Farbe | White to Yellow to Green |
| Merck | 14,4132 |
| InChI | InChI=1S/C18H18F3NO2/c1-2-3-11-24-17(23)15-9-4-5-10-16(15)22-14-8-6-7-13(12-14)18(19,20)21/h4-10,12,22H,2-3,11H2,1H3 |
| InChIKey | JDLSRXWHEBFHNC-UHFFFAOYSA-N |
| SMILES | C(OCCCC)(=O)C1=CC=CC=C1NC1=CC=CC(C(F)(F)F)=C1 |
| LogP (Verteilungskoeffizient) | 6.92 |
Sicherheit & Vorschriften
| GHS-Einstufung | WarningH302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 3 reports by companies from 2 notifications to the ECHA C&L Inventory. |
|---|---|
| Regulatorische Informationen | REACH registered substance: Benzoic acid, 2-[[3-(trifluoromethyl)phenyl]amino]-, butyl ester (EC: 614-050-1) |
| Hazard Classes and Categories | Acute Tox. 4 (100%) |
| Zollcode | 2922.49.2600 |
| RTECS-Nr. | DH8511000 |
Anwendungen & Verwendung
Beschreibung
Butyl flufenamate is a topical, non-steroidal antiinflammatory agent indicated for the treatment of acute and chronic eczema; contact, seborrheic, and atopic dermatitis; and herpes zoster.
Verwenden
Ufenamate serves an ointment in treatment of facial hormone-dependent dermatitis, treatment of cephalic chronic eczema and neurodermatitis