ethyl 2,4-dimethyl-5-[(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrole-3-carboxylate
Grundinformationen
- CAS
15966-93-5- Standard-SMILES
CCOC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3ccccc32)c1C- InChIKey
PMUJUSJUVIXDQC-UHFFFAOYSA-N- Summenformel
- C18H18N2O3
- Durchschnittliche Molmasse
- 310,3 g/mol
- Monoisotopische Masse
- 310,13174244
Namen und Bezeichner
- Bevorzugter Name
- ethyl 2,4-dimethyl-5-[(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrole-3-carboxylate
- IUPAC
- ethyl 2,4-dimethyl-5-[(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrole-3-carboxylate
- Englischer Name
- VEGFR2 Kinase Inhibitor I
- Summenformel
- C18H18N2O3
- Molmasse
- 310.35
Namen und Synonyme
SU5408ethyl 2,4-dimethyl-5-[(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrole-3-carboxylateVEGFR2 Kinase Inhibitor IEthyl 2,4-dimethyl-5-((2-oxoindolin-3-ylidene)methyl)-1H-pyrrole-3-carboxylateMFCD04974538ethyl 2,4-dimethyl-5-[(2-oxoindolin-3-ylidene)methyl]-1H-pyrrole-3-carboxylatePMUJUSJUVIXDQC-UHFFFAOYSA-NIN1018VEGFR2 kinase inhibiSCHEMBL5390359DTXSID30274474GLXC-23454
Weitere Namen anzeigen
SU5408 ,S6514VEGFR2 TK InhibitorSU5408, 10 mM in DMSOSU 5408SU-5408VEGFR2 KISE INHIBITOR IResearch Grade RamucirumabVEGFR2 kinase inhibitor I(SU-5408)Research Grade Ramucirumab(DHE16601)
1H-Pyrrole-3-carboxylic acid, 5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-, ethyl esterethyl 2,4-dimethyl-5-[(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-1H-pyrrole-3-carboxylateS6514(2,4-Dimethyl-3-ethoxycarbonylpyrrol-5-yl methylene]-2-indolinone3-[(2,4-dimethyl-3-ethoxycarbonylpyrrol-5-yl) methylene]-2-indolinone3-[(2,4-Dimethyl-3-ethoxycarbonylpyrrol-5-yl)methylene]-2-indolinoneethyl (E)-2,4-dimethyl-5-((2-oxoindolin-3-ylidene)methyl)-1H-pyrrole-3-carboxylate
Datenbank-Bezeichner
- CAS
15966-93-5- PubChem CID
- 5654
- DTXSID
DTXSID30274474
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 2,7
- Polarare Oberfläche (TPSA)
- 71,2 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 3
- Frei drehbare Bindungen
- 4
- Schwere Atome
- 23
- Formalladung
- 0
- Komplexität
- 516
Physikochemische Eigenschaften
- Siedepunkt
- 571.4 · 571.4±50.0 °C(Predicted)
- Dichte
- 1.271 · 1.271±0.06 g/cm3(Predicted)
- storage temp.
- -20 °C · Sealed in dry,Store in freezer, under -20°C
- Löslichkeit
- 1 mg/ml; · DMF: 1 mg/ml; DMSO: 1 mg/ml
- Aggregatzustand
- A crystalline solid
- pka
- 12.4 · 12.40±0.20(Predicted)
- Farbe
- Yellow to orange
Chemie und Industrie
Anwendungen
VerwendenVEGFR 2 Kinase Inhibitor blocks mutant huntingtin (Htt) cellular toxicity in Huntington’s disease.
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