Vesnarinone

HCID 5663CAS 81840-15-5

Grundinformationen

Standard-SMILES
COc1ccc(C(=O)N2CCN(c3ccc4c(c3)CCC(=O)N4)CC2)cc1OC
InChIKey
ZVNYJIZDIRKMBF-UHFFFAOYSA-N
Summenformel
C22H25N3O4
Durchschnittliche Molmasse
395,5 g/mol
Monoisotopische Masse
395,18450629

Namen und Bezeichner

Bevorzugter Name
Vesnarinone
IUPAC
6-[4-(3,4-dimethoxybenzoyl)piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one
Englischer Name
VESNARINONE
Summenformel
C22H25N3O4
Molmasse
395.45

Namen und Synonyme

vesnarinone81840-15-5OPC-8212Arkin-ZVesnarinonaArkinArkin ZVesnarinonumDRG-02105COW40EV8MDTXSID802314111-(3,4-Dimethoxybenzoyl)-4-(1,2,3,4-tetrahydro-2-oxo-6-quinolinyl)piperazine
Weitere Namen anzeigen
OPC 8212CS-21390PC-8212PiteranometozineVesnarinone(OPC8212)VESNARINONE USP/EP/BPOPC8212OPC 8212Vesnarinone, 10 mM in DMSO
pieranometazine6-(4-((3,4-dimethoxyphenyl)carbonyl)piperazin-1-yl)-1,2,3,4-tetrahydroquinolin-2-one6-{4-[(3,4-dimethoxyphenyl)carbonyl]piperazin-1-yl}-1,2,3,4-tetrahydroquinolin-2-oneRefChem:9018293,4-dihydro-6-(4-(3,4-dimethoxybenzoyl)-1-piperazinyl)-2-1H-quinolinoneDTXCID801539023,4-Dihydro-6-(4-(3,4-dimethoxybenzoyl)-1-pip-erazinyl)-2(1H)-quinolinonePiperazine, 1-(3,4-dimethoxybenzoyl)-4-(1,2,3,4-tetrahydr-o-2-oxo-6-quinolinyl)

Datenbank-Bezeichner

CAS
81840-15-5
PubChem CID
5663
DTXSID
DTXSID80231411
ChEMBL
CHEMBL17423
ChEBI
CHEBI:31237
UNII
5COW40EV8M
Nikkaji
J22.952K

Eigenschaften

Berechnete Struktureigenschaften

XLogP
2,1
Polarare Oberfläche (TPSA)
71,1 Ų
H-Brücken-Donoren
1
H-Brücken-Akzeptoren
5
Frei drehbare Bindungen
4
Schwere Atome
29

Physikochemische Eigenschaften

Schmelzpunkt
238.1 · 238.1-239.5° (Tominaga); mp 238.1-239.8° (Shimizu)
Siedepunkt
519.41 °C · 519.41°C (rough estimate)
Dichte
1.2414 · 1.2414 (rough estimate)
Brechungsindex
1.65 · 1.6500 (estimate)
storage temp.
-20 °C · Store at -20°C
Löslichkeit
9.84 · DMSO:9.84(Max Conc. mg/mL);24.88(Max Conc. mM)DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.26(Max Conc. mM)DMF:3.0(Max Conc. mg/mL);7.59(Max Conc. mM)

Sicherheit und Regulatorisches

Sicherheitsdaten

Alarmwort
Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H302

Chemie und Industrie

Pharmakologische Informationen

MeSH Pharmacological Classification · 5 Einträge

Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.

Substances that inhibit or prevent the proliferation of NEOPLASMS.

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.

Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).

Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases.

Cellular LocationsMembrane
Anwendungen · 2 Einträge

BeschreibungVesnarinone is a new orally-active positive inotropic agent introduced for the treatment of congestive heart failure. It exerts a positive inotropic effect on the heart and has a peripheral vasodilatory effect. Vesnarinone is claimed not to affect heart rate or aggravate arrhythmia.

VerwendenCardiotonic.

Vor- und nachgelagerte Produkte

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