Diammin[cyclobutan-1,1-dicarboxylato(2-)-O,O']platin
Carboplatin (USAN:USP:INN:BAN:JAN)
Grundinformationen
- CAS
41575-94-4- Standard-SMILES
N.N.O=C([O-])C1(C(=O)[O-])CCC1.[Pt+4]- InChIKey
BHKICZDKIIDMNR-UHFFFAOYSA-L- Summenformel
- C6H12N2O4Pt+2
- Durchschnittliche Molmasse
- 371,25 g/mol
- Monoisotopische Masse
- 371,044501
Namen und Bezeichner
- Bevorzugter Name
- Carboplatin (USAN:USP:INN:BAN:JAN)
- IUPAC
- azane;cyclobutane-1,1-dicarboxylate;platinum(4+)
- Lokaler Name
- Diammin[cyclobutan-1,1-dicarboxylato(2-)-O,O']platin
- Englischer Name
- Carboplatin
- Summenformel
- C6H12N2O4Pt
- Molmasse
- 371.25
Namen und Synonyme
Carboplatinum [Latin]CCRIS 3404HSDB 6957EINECS 255-446-0NSC 201345Carboplatin [USAN:USP:INN:BAN:JAN]Diammine-1,1-cyclobutane dicarboxylate platinum IICarboplatinum (Latin)Platinum(II), (1,1-cyclobutanedicarboxylato)diammine-, cis-1,1-Cyclobutanedicarboxylate diammine platinum(II)Diammine(cyclobutane-1,1-dicarboxylato(2-)-O,O')platinumDiammine[cyclobutane-1,1-dicarboxylato(2-)-O,O']platinum
Weitere Namen anzeigen
PARAPLATINcbdcaCarboplat1,1-cyclobutanedicarboxylatediammineplatinum(ii)Platinum, diammine[1,1-cyclobutanedi(carboxylato-kO)(2-)]-, (SP-4-2)-ErcarCarbopLFITC-CBPNSC-17102
Platinum, diammine(1,1-cyclobutanedicarboxylato(2-)-O,O')-, (SP-4-2)Carboplatin (USAN:USP:INN:BAN:JAN)RefChem:574585JM 8JM-8Carboplatine [French]Carboplatino [Spanish]UNII-BG3F62OND5
Datenbank-Bezeichner
- CAS
41575-94-4- PubChem CID
- 56840877
- EC Number
- 255-446-0
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 82,3 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 6
- Frei drehbare Bindungen
- 0
- Schwere Atome
- 13
- Formalladung
- 2
- Komplexität
- 177
Experimentelle und physikochemische Eigenschaften
Human DrugsBreast Feeding; Lactation; Milk, Human; Antineoplastic Agents; Platinum Compounds
Physikochemische Eigenschaften
- Schmelzpunkt
- 228 · 228-230°C
- storage temp.
- 2 · 2-8°C
- Löslichkeit
- Sparingly soluble in water, very slightly soluble in acetone and in ethanol (96 per cent).
- Aggregatzustand
- crystal
- Farbe
- white
- Wasserlöslichkeit
- Soluble in water.
- Merck
- 14 · 14,1822
- Stabilität
- Stable. Incompatible with strong oxidizing agents.
- InChI
- InChI=1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2/p-2
- InChIKey
- OLESAACUTLOWQZ-UHFFFAOYSA-L
- SMILES
- C12(CCC1)C(=O)O[Pt]OC2=O.N.N
- EPA chemische Informationen
- Carboplatin (41575-94-4)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Danger
H302+H312+H332 (48.8%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]
P203, P233, P260, P261, P263, P264, P264+P265, P270, P271, P272, P280, P284, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P318, P321, P330, P333+P317, P337+P317, P342+P316, P362+P364, P403, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 82 reports by companies from 16 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Toxikologische Informationen
Effects During Pregnancy and Lactation◉ Summary of Use during Lactation
Sicherheitsdaten
- wgk
- 3
- ridadr
- 2811
- hs_code
- 28439000
- RTECS-Nr.
- TP2300000
- risk_code
- 46-61-20/21/22-42/43-20/21
- Toxizität
- LD50 in mice (mg/kg): 150 i.p., 140 i.v.; in rats (mg/kg): 85 i.v. (Lelieveld)
- hazard_code
- T
- safety_code
- 53-22-26-36/37/39-45
- Speicherklasse
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
- Giftige Stoffe Daten
- 41575-94-4(Hazardous Substances Data)
- Hazard Classifications
- Acute Tox. 4 DermalAcute Tox. 4 InhalationAcute Tox. 4 OralMuta. 1BRepr. 1BResp. Sens. 1Skin Sens. 1
Chemie und Industrie
Anwendungen
BeschreibungCarboplatin is a second generation, platinum-containing antineoplastic agent with significantly reduced nephro-, neuro-, and ototoxicity in comparison to cisplatin. It is effective in the treatment of advanced ovarian carcinoma of epithelial origin and small cell carcinoma of the lung.
VerwendenData on carboplatin production have not been found. Carboplatin is used in chemotherapy to treat cancer, and more particularly to treat cancer of ovary, embryonal carcinoma of the testis, microcellular carcinoma of the lung, neuroblastoma, and squamous cell carcinomas of the head and neck.
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