Iobenguane Sulfate I-123
Grundinformationen
- CAS
139755-80-9- Standard-SMILES
NC(N)=NCc1cccc([123I])c1.NC(N)=NCc1cccc([123I])c1.O=S(=O)(O)O- InChIKey
XNACDNPGABUBFR-FKNPGSCZSA-N- Summenformel
- C16H22I2N6O4S
- Durchschnittliche Molmasse
- 640,3 g/mol
- Monoisotopische Masse
- 639,9535
Überblick
Iobenguane sulfate I-123 is a radiopharmaceutical used in gamma-scintigraphy of adrenergically inervated tissues.
Namen und Bezeichner
- Bevorzugter Name
- Iobenguane Sulfate I-123
- IUPAC
- bis(2-[(3-(123I)iodophenyl)methyl]guanidine);sulfuric acid
- Englischer Name
- 3-Iodobenzyl-guanidine hemisulfate
- Summenformel
- C8H12IN3O4S
- Molmasse
- 373.16805
Namen und Synonyme
Iobenguane sulfate I 123IOBENGUANE SULFATE I-123Iobenguane sulphate i 123Iobenguane sulphate i-123Iobenguane i 123 hemisulfateIobenguane i-123 hemisulfateUNII-23X1185WBOIobenguane i 123 hemisulphateIobenguane i-123 hemisulphateIobenguane, i-123 hemisulfateIobenguane, i-123 hemisulphate23X1185WBO
Weitere Namen anzeigen
AdreviewIobenguane sulfate-I-131Guanidine, [[3-(iodo-123I)phenyl]methyl]-, sulfate (2:1) (9CI)
IODOBENZYLGUANIDINE SULFATE I 123(m-Iodo-(sup 123)I)-benzyl)guanidine sulfate (2:1)IODOBENZYLGUANIDINE SULPHATE I 123((3-(Iodo-(sup 123)I)-phenyl)methyl)guanidine sulfate (2:1)(M-IODO-(SUP 123)I)-BENZYL)GUANIDINE SULPHATE (2:1)((3-(IODO-(SUP 123)I)-PHENYL)METHYL)GUANIDINE SULPHATE (2:1)RefChem:56319I 123 mibg
Datenbank-Bezeichner
- CAS
139755-80-9、80663-95-2- PubChem CID
- 56840904
- ChEMBL
CHEMBL3989523- UNII
- 23X1185WBO
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 212 Ų
- H-Brücken-Donoren
- 6
- H-Brücken-Akzeptoren
- 6
- Frei drehbare Bindungen
- 4
- Schwere Atome
- 29
- Formalladung
- 0
- Komplexität
- 247
Experimentelle und physikochemische Eigenschaften
SolubilitySoluble
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- hs_code
- 29215900
Chemie und Industrie
Pharmakologische Informationen
PharmacodynamicsIobenguane I-123 is taken up by and stored in adrenergic nerve terminals allowing for the radiographic imaging of adrenergically inervated organs and tissues.
Mechanism of Action
Iobenguane I-123 is transported into adrenergic nerve terminals via the noradrenaline uptake transporter. It is rapidly cleared from systemic circulation and collected in adrenergically invervated tissues. This allows for gamma-scintigraphic imaging of these tissues and their associated organs for diagnostic purposes.
Metabolism/MetabolitesMetabolized to m-iodohippuric acid and free radioiodide. The metabolism of iobenguane I-123 and the enzymes involved has not been well studied.
FDA Pharmacological Classification
23X1185WBO
IOBENGUANE SULFATE I-123
Established Pharmacologic Class [EPC] - Radioactive Diagnostic Agent
Mechanisms of Action [MoA] - Radiopharmaceutical Activity
Iobenguane sulfate i-123 is a Radioactive Diagnostic Agent. The mechanism of action of iobenguane sulfate i-123 is as a Radiopharmaceutical Activity.
Absorption, Distribution and Excretion
Primarily eliminated via the urine as the parent compound (70-90%). A small amount is eliminated in the urine as m-iodohippuric acid (</10%) and free radioiodide (</6%). Less than 1% is eliminated in the feces. Iobenguane I-123 is initially rapidly cleared from circulation follwed by a slow clearance from other tissues over 4 days. Retention is the longest in highly adrenergically inervated tissues like the adrenal medulla, heart, and salivary glands. Iobenguane I-123 is not cleared by dialysis.
Anwendungen
VerwendenRadioactive agent.
Anbieter2 Anbieter
BOC Sciences1-631-485-4226; 16314854226 · [email protected]
青岛海智微元生物科技有限公司18317699790 18317699790 · [email protected]
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