Dexamethasone; Neomycin Sulfate; Polymyxin B Sulfate
Grundinformationen
- CAS
78666-15-6- Standard-SMILES
CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H](C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCN)NC1=O)C(C)O.C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO.NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)[C@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3N)O[C@@H]2CO)[C@H](N)[C@@H](O)[C@@H]1O.O=S(=O)(O)O.O=S(=O)(O)O- InChIKey
AYPVKEUFFRLHGM-UPXXUEPXSA-N- Summenformel
- C101H177FN22O39S2
- Durchschnittliche Molmasse
- 2.406,7 g/mol
- Monoisotopische Masse
- 2.405,1968744
Überblick
Neomycin Sulfate/Polymyxin B Sulfate/Dexamethasone is a topical combination preparation containing the sulfate salt form of the aminoglycoside antibiotic neomycin, the sulfate salt form of the polypeptide antibiotic polymyxin B, and the glucocorticoid dexamethasone, with antimicrobial, anti-infective and anti-inflammatory activities. Upon topical application, neomycin irreversibly binds to the bacterial 30S ribosomal subunit, thereby preventing mRNA from binding, causing both misreading and the inhibition of protein synthesis. Polymyxin B binds, with its positively charged amino groups, to negatively charged phospholipids in the outer cell membrane of Gram-negative bacteria, thereby disrupting cell wall integrity and altering the permeability of the bacterial cytoplasmic membrane. Dexamethasone binds to the cytoplasmic glucocorticoid receptor, and this receptor-ligand complex is translocated to the nucleus where it initiates the transcription of genes encoding for anti-inflammatory mediators, such as cytokines and lipocortins.
Namen und Bezeichner
- Bevorzugter Name
- Dexamethasone; Neomycin Sulfate; Polymyxin B Sulfate
- IUPAC
- (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol;N-[(2S)-4-amino-1-[[(2S)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide;(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one;sulfuric acid
- Englischer Name
- maxitrol
- Summenformel
- C101H177FN22O39S2
- Molmasse
- 2406.7384832
Namen und Synonyme
DexacidinDEXASPORINNEO-POLY-DEXRefChem:57695Neomycin, Polymyxin B Sulfates, DexamethasoneNeomycin Polymyxin B Sulfates and DexamethasoneNEOMYCIN, POLYMYXIN B AND DEXAMETHASONEDexamethasone/Neomycin Sulfate/Polymyxin B SulfateDexamethasone/Polymyxin B Sulfate/Neomycin SulfateDexamethasone;Neomycin Sulfate;Polymyxin B SulfateDexamethasone;Polymyxin B Sulfate;Neomycin SulfateNeomycin Sulfate/Polymyxin B Sulfate/Dexamethasone
Weitere Namen anzeigen
maxitrol(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-oneN-[(2S)-4-amino-1-[[(2S)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 1.100 Ų
- H-Brücken-Donoren
- 38
- H-Brücken-Akzeptoren
- 51
- Frei drehbare Bindungen
- 40
- Schwere Atome
- 165
- Formalladung
- 0
- Komplexität
- 3.910
Experimentelle und physikochemische Eigenschaften
Human DrugsFDA approved drugs -> Active ingredient
Zugehörige Reaktionen
0
Keine Reaktionsaufzeichnungen unter den aktuellen Filterkriterien.
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