CAS 957054-33-0 Pictilisib Bismesylate (HCID 56972143)

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Grundinformationen

CAS: 957054-33-0
Standard-SMILES: CS(=O)(=O)N1CCN(Cc2cc3nc(-c4cccc5[nH]ncc45)nc(N4CCOCC4)c3s2)CC1.CS(=O)(=O)O.CS(=O)(=O)O
InChIKey: RFRIKACSFOTIMU-UHFFFAOYSA-N
Summenformel: C25H35N7O9S4
Durchschnittliche Molmasse: 705,9 g/mol
Monoisotopische Masse: 705,13791041

Überblick

Pictilisib Bismesylate is the orally bioavailable bismesylate salt of pictilisib, a small molecule inhibitor of class I phosphatidylinositol 3 kinase (PI3K), with potential antineoplastic activity. Upon administration, pictilisib selectively binds to PI3K in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway. This may result in inhibition of tumor cell growth, motility and survival in susceptible tumor cell populations. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis; dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

Namen und Bezeichner

Bevorzugter Name: Pictilisib Bismesylate
IUPAC: 4-[2-(1H-indazol-4-yl)-6-[(4-methylsulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine;methanesulfonic acid
Englischer Name: GDC-0941 Bimesylate
Summenformel: C24H30N7O6S3
Molmasse: 608.7333

Namen und Synonyme

GDC-0941 dimesylatePictilisib bismesylatePictilisib dimesylateG3D7HF2GS9UNII-G3D7HF2GS9GDC-0941 BismesylateThieno(3,2-d)pyrimidine, 2-(1H-indazol-4-yl)-6-((4-(methylsulfonyl)-1-piperazinyl)methyl)-4-(4-morpholinyl)-, methanesulfonate (1:2)Thieno[3,2-d]pyrimidine, 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-, methanesulfonate (1:2)2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno(3,2-d)pyrimidine, bimesylate salt2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine, bimesylate saltRefChem:174205957054-33-0

Weitere Namen anzeigen

Pictilisib mesylatePictilisib (GDC-0941)GDC-0941 (2 MeSO3H salt)GDC 0941 (2 MeSO3H salt)GDC-0941 Bimesylate USP/EP/BPGDC-0941 BiMesylate/pictilisib

GDC-0941 dimethanesulfonateGDC-0941 BimesylatePictilisib (dimethanesulfonate)Pictilisib dimethanesulfonateGDC-0941 (dimethanesulfonate)GDC 0941 bimesylate4-[2-(1H-indazol-4-yl)-6-[(4-methylsulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine;methanesulfonic acid4-(2-(1H-indazol-4-yl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine dimethanesulfonate

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA): 270 Å²
H-Brücken-Donoren: 3
H-Brücken-Akzeptoren: 16
Frei drehbare Bindungen: 5
Schwere Atome: 45
Formalladung: 0
Komplexität: 924

Physikochemische Eigenschaften

Schmelzpunkt: 280 °C · >280°C (dec.)
storage temp.: Refrigerator
Löslichkeit: DMSO (Slightly, Heated), Methanol (Sparingly)
Aggregatzustand: Solid
Farbe: White to Pale Yellow

Chemie und Industrie

Anwendungen

VerwendenPotent inhibitor of Phosphatidylinositol 3-kinase (PI3K)

Anbieter59 Anbieter

成都超九八生物科技有限公司13348960310 13348960310 · [email protected]

苏州奥佰医药科技有限公司1483287082 19962651230 · [email protected]

上海波以尔化工有限公司[email protected]

United Life Science020-82099279 18988941402 · [email protected]

InvivoChem中国13549236410 · [email protected]

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Reaktionsaufzeichnung erstellen

HRID 505028als Produktuspto-grants-2010_08

HRID 876567als Produktuspto-grants-2015_03

HRID 2188624als Produktuspto-grants-2012_12

HRID 2358996als Produktuspto-grants-2014_04

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