Scopolamine Hydrobromide Trihydrate
screen · tripton · Benzeneacetic acid, .alpha.-(hydroxymethyl)-, (1.alpha.,2.beta.,4.beta.,5.alpha.,7.beta.)-9-methyl-3-oxa-9-azatricyclo3.3.1.02,4non-7-yl ester, hydrobromide, trihydrate, (.alpha.S)- · C17H21NO4BRH3H2O · Scopolamine CRS. · Scopolamine-d3.HBr · Tiotropium Impurity 21 · ),hydrobromide,trihydrate
Identifikatoren & physikalische Daten
| CAS No. | 6533-68-2 |
|---|---|
| Summenformel | C17H24BrNO5 |
| Durchschnittliche Molmasse | 402,29 g/mol |
| SMILES | Br.CN1C2CC(OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@H]1OC21 |
| PubChem CID | 5702113 |
Chemische & physikalische Eigenschaften
| Schmelzpunkt | 197-194 °C |
|---|---|
| Brechungsindex | -25.5 ° (C=5, H2O) |
| Lagerbedingungen | Poison room |
| Löslichkeit | H2O: soluble50mg/mLH2O: 50mg/mL |
| Aggregatzustand | Crystals or Crystalline Powder |
| Farbe | white to off-white |
| Merck | 14,8406 |
| BRN | 6100669 |
| Stabilität | Stable, but air and light sensitive. Incompatible with acids, bases, strong oxidizing agents. Slightly hygroscopic. |
| InChI | InChI=1/C17H21NO4.BrH.H2O/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10/h2-6,11-16,19H,7-9H2,1H31H2/t11-,12-,13-,14+,15-,16+/s3 |
| InChIKey | UXOOBDDSNJVVBU-MJICIYPYNA-N |
| SMILES | CN1[C@@H]2C[C@@H](OC(=O)[C@@H](C3C=CC=CC=3)CO)C[C@H]1[C@@H]1O[C@H]21.Br.O |&1:2,4,8,18,19,21,r| |
| LogP (Verteilungskoeffizient) | 0.760 (est) |
| CAS Datenbank | 6533-68-2(CAS DataBase Reference) |
| EPA chemische Informationen | Scopolamine hydrobromide trihydrate (6533-68-2) |
Sicherheit & Vorschriften
| Wassergefährdungsklasse (WGK) | 1 |
|---|---|
| UN-Transportnummer | UN1544 6.1/PG 3 |
| Zollcode | 29399990 |
| RTECS-Nr. | YM4550000 |
| R-Sätze (R) | 26/27/28 |
| Gefahrensymbole | T+ |
| Sicherheitshinweise (S) | 45-25-1 |
| Gefahrenklasse | 6.1Acute Tox. 1 DermalAcute Tox. 2 InhalationAcute Tox. 2 Oral |
| Verpackungsgruppe | III |
| Lagerklasse | 6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials |
Anwendungen & Verwendung
Beschreibung
Scopolamine hydrobromide is a bronchodilator indicated for the maintenance treatment of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema, the maintenance treatment of concomitant dyspnea and the prevention of acute exacerbations.
Verwenden
Scopolamine is a nasal decongestant and adrenergic agonist that is used to dilate the pupil, reduce eye focusing ability, control saliva and gastric acid production, slow intestinal movements, and prevent vomiting.