CAS 10465-81-3 diazenedicarboxylic acid bis(N,N-piperidide) (HCID 5702657)

Überblick

less cytotoxic than diamide

Namen und Bezeichner

Bevorzugter Name: diazenedicarboxylic acid bis(N,N-piperidide)
IUPAC: (NE)-N-(piperidine-1-carbonylimino)piperidine-1-carboxamide
Englischer Name: 1,1'-(Azodicarbonyl)-dipiperidine
Summenformel: C12H20N4O2
Molmasse: 252.31

Namen und Synonyme

10465-81-3SR-4077Diazenedicarboxylic acid bis(N,N-piperidide)RefChem:1327451,1'-(Azodicarbonyl)dipiperidine(NE)-N-(piperidine-1-carbonylimino)piperidine-1-carboxamide1,1-(Azodicarbonyl)dipiperidineAdDP(E)-diazene-1,2-diylbis(piperidin-1-ylmethanone)NSC356027871024-86-1MFCD00010111

Weitere Namen anzeigen

Diazene-1,2-diylbis(piperidin-1-ylMethanone)sr4077Azodicarboxylic1,1'-(Azodicarbo1,1'-(Azodicarbonyl)Diphenylpiperidylcarboxylate

NSC-356027azodicarbonyldipiperidineN-[(piperidine-1-carbonyl)imino]piperidine-1-carboxamideNSC 356027SR 4077(NE)-N-{[(E)-piperidine-1-carbonyl]imino}piperidine-1-carboxamidePiperidine, 1,1'-(azodicarbonyl)bis-1,1'-Azobis(N,N-pentamethyleneformamide)

Datenbank-Bezeichner

CAS: 10465-81-3、871024-86-1
PubChem CID: 5702657
UNII: 5TDP5Q98AM
EC Number: 629-528-5
Nikkaji: J81.512H

Eigenschaften

Berechnete Struktureigenschaften

XLogP: 1,9
Polarare Oberfläche (TPSA): 65,3 Å²
H-Brücken-Donoren: 0
H-Brücken-Akzeptoren: 2
Frei drehbare Bindungen: 0
Schwere Atome: 18
Formalladung: 0
Komplexität: 299

Physikochemische Eigenschaften

Schmelzpunkt: 132 · 132-136 °C(lit.)
Siedepunkt: 366.4 · 366.4±25.0 °C(Predicted)
Dichte: 1.29 · 1.29±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit: DMSO (Slightly), Methanol (Slightly), insol petroleum ether; sol ethanol, ether, THF
pka: 0 · -0+-.0.20(Predicted)
Aggregatzustand: solid
Farbe: yellow
Wasserlöslichkeit: Slightly soluble in water.
BRN: 261917 · 261917
InChI: InChI=1S/C12H20N4O2/c17-11(15-7-3-1-4-8-15)13-14-12(18)16-9-5-2-6-10-16/h1-10H2
InChIKey: OQJBFFCUFALWQL-UHFFFAOYSA-N
SMILES: N(C(N1CCCCC1)=O)=NC(N1CCCCC1)=O
CAS Datenbank: 10465 · 10465-81-3(CAS DataBase Reference)

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 4 Einträge

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 48 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Hazard Classes and CategoriesSkin Irrit. 2 (100%)

Sicherheitsdaten

wgk: 3
tsca: No
ridadr: 3234
hs_code: 29339900
risk_code: 36/37/38
hazard_code: Xi
safety_code: 26-36

Chemie und Industrie

Anwendungen · 2 Einträge

Beschreibung1,1''-(Azodicarbonyl)dipiperidine (ADDP) is a reagent commonly used in the Mitsunobu reaction for the condensation of an alcohol and an acidic compound. It has been used as a reagent in the synthesis of G protein-coupled receptor 120 (GPR120) agonists with antidiabetic activity and peroxisome proliferator-activated receptor α (PPARα), PPARγ, and PPARδ triple agonists.

VerwendenIt is used in a study of the copper-catalyzed addition of aryboronic acids to azodicarboxyl derivatives providing aryl-substituted hydrazides. It is widely used reagent for the Mitsunobu reaction. It is reactant for preparation of polyfluoroalkylated tripyrazolylmethane ligands, (-)-Hygromycin A via Mitsunobu glycosylation, optically active α,α-disubstituted amino acids via Mitsunobu reaction, aza-β-lactams through [2+2] cycloaddition reactions, glycosyl disulfides, pyridine ether PPAR agonists, S-glycosyl amino acid, building blocks for combinatorial neoglycopeptide synthesis and is a histamine H3 receptor antagonists. It is a reactant for Mitsunobu inversion reactions.