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Grundinformationen
- CAS
1953-04-4- Standard-SMILES
COc1ccc2c3c1O[C@H]1C[C@@H](O)C=C[C@@]31CC[NH+](C)C2.[Br-]- Summenformel
- C17H22BrNO3
- Durchschnittliche Molmasse
- 368,27 g/mol
Namen und Bezeichner
- Bevorzugter Name
- Galantamine Hydrobromide
- Lokaler Name
- Galantaminhydrobromid
- Englischer Name
- Galantamine Hydrobromide
- Summenformel
- C17H22BrNO3
- Molmasse
- 368.27
Namen und Synonyme
GALANTAMINE HBRGALANTHAMINE HBRNIVALINGALANTHAMIDE HYDROBROMIDE4A,5,9,10,11,12-HEXAHYDRO-3-METHOXY-11-METHYL-6H-BENZOFURO[3A,3,2-EF][2]BENZAZEPIN-6-OL HYDROBROMIDE(4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, HydrobromideNIVALIN, HBRGalanthamine HCIGALANTAMINE HYDROBROMIDEGALANTAMINE HYDROBROMIDE
Datenbank-Bezeichner
- CAS
1953-04-4- PubChem CID
- 57904004
Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 256 °C · 256 °C
- Brechungsindex
- -95 ° · -95 ° (C=1.4, H2O)
- storage temp.
- -20 °C · Inert atmosphere,Store in freezer, under -20°C
- Löslichkeit
- Sparingly soluble in water, very slightly soluble in anhydrous ethanol. It dissolves in dilute solutions of alkali hydroxides.
- Aggregatzustand
- White to off-white crystalline solid.
- Farbe
- White to Orange to Green
- Wasserlöslichkeit
- Soluble in water or DMSO
- Merck
- 14 · 14,4340
- Major Application
- pharmaceutical (small molecule)
- InChI
- InChI=1/C17H21NO3.BrH/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17;/h3-6,12,14,19H,7-10H2,1-2H3;1H/t12-,14-,17-;/s3
- InChIKey
- QORVDGQLPPAFRS-ORFATOSYNA-N
- SMILES
- [C@@]123CCN(C)CC4=CC=C(OC)C(O[C@H]1C[C@@H](O)C=C2)=C34.Br |&1:0,14,16,r|
- LogP
- 1.75 · 1.750 (est)
- CAS Datenbank
- 1953 · 1953-04-4(CAS DataBase Reference)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- 3
- ridadr
- UN 2811 6.1/PG 3
- hs_code
- 29399990
- RTECS-Nr.
- DF8075000
- risk_code
- 25
- Toxizität
- LD50 i.v. in mice (mg/kg): 5.2 ± 0.2 (Friess)
- hazard_code
- T
- safety_code
- 45-36/37/39-22
- hazard_class
- 6.1
- packing_group
- II
- Speicherklasse
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
- Hazard Classifications
- Acute Tox. 3 Oral
Chemie und Industrie
Anwendungen
VerwendenGalantamine hydrobromide (marketed as Reminyl) is one of a group of three drugs for people with Alzheimer's disease called cholinesterase inhibitors. The other two are called donepezil hydrochloride (common brand name Aricept) and rivastigmine (common brand name Exelon). It is a selective acetylcholinesterase inhibitor that for the treatment and prevention of Alzheimer's disease and other diseases resulting from reduced neuronal metabolism.
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