HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-(2-Butoxyethoxy)ethyl-6-propylpiperonylether
PBO · Butoxide · 5-[2-(2-BUTOXYETHOXY)ETHOXYMETHYL]-6-PROPYL-1,3-BENZODIOXOLE · BUTACIDE · Poperonyl butoxide · Piperronyl butoxide · PIPERONYL BUTOXIDE, TECH., 90% · 1,3-Benzodioxole, 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-
Identifikatoren & physikalische Daten
| CAS No. | 51-03-6 |
|---|---|
| Summenformel | C19H30O5 |
| Durchschnittliche Molmasse | 338,4 g/mol |
| Monoisotopische Masse | 338,20932406 g/mol |
| SMILES | CCCCOCCOCCOCc1cc2c(cc1CCC)OCO2 |
| InChIKey | FIPWRIJSWJWJAI-UHFFFAOYSA-N |
| PubChem CID | 5794 |
| ChEMBL | CHEMBL1201131 |
| ChEBI | CHEBI:32687 |
| EC No. | 200-076-7 |
| DTXSID | DTXSID1021166 |
| Lokaler Name | 2-(2-Butoxyethoxy)ethyl-6-propylpiperonylether |
Chemische & physikalische Eigenschaften
| XLogP | 3,7 |
|---|---|
| Polarare Oberfläche (TPSA) | 46,2 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 5 |
| Frei drehbare Bindungen | 13 |
| Schwere Atome | 24 |
| Formalladung | 0 |
| Komplexität | 312 |
| Arzneimittel | Pharmaceuticals -> Listed in ZINC15 |
| Pestizide | Pesticides -> Other InsecticidesPesticide (Piperonyl butoxide) -> USDA PDB |
| LogP (Verteilungskoeffizient) | log Kow = 4.754.29 |
| Geruch | ODORLESSMild odor |
| Geschmack | FAINT BITTER TASTE |
| Dichte | 1.04 to 1.07 at 68 °F (NTP, 1992)1.06 at 20 °CRelative density (water = 1): 1.11.04-1.071.06 @ 20°C1.059 g/mL at 25 °C(lit.) |
| Viscosity | 40 cP at 25 °C |
| Color/Form | Colorless liquidPale yellowish liquidLight brown liquid |
| Löslichkeit | less than 1 mg/mL at 64 °F (NTP, 1992)Miscible with methanol, ethanol, benzene, Freons, Geons, petroleum oils, and other organic solventsIn water, 14.3 mg/L at 25 °CSolubility in water: nonewater: slightly soluble0.0289g/L at 20.4°C<0.1 g/100 mL at 18 ºC |
| Corrosivity | NONCORROSIVE |
| Flammpunkt | 340 °F (NTP, 1992)171 °C340 °F (171 °C) (open cup)>230 °F |
| Human Drugs | FDA approved drugs -> Active ingredient |
| Schmelzpunkt | <25 °C |
| Siedepunkt | 180 °C |
| Dampfdruck | 0.02 hPa (60 °C) |
| Brechungsindex | n20/D 1.498(lit.) |
| Lagerbedingungen | 2-8°C |
| Aggregatzustand | Liquid |
| Wichte | 1.060 (20/4℃) |
| Farbe | Clear yellow |
| Geruch | mild odor or odorless |
| Merck | 14,7476 |
| BRN | 288063 |
| Henry-Konstante | 1.1×105 mol/(m3Pa) at 25℃, HSDB (2015) |
| Stabilität | Stable. Combustible. Incompatible with oxidizing agents. |
| Kosmetik-Inhaltsstoffe Funktionen | SKIN PROTECTING |
| InChI | 1S/C19H30O5/c1-3-5-7-20-8-9-21-10-11-22-14-17-13-19-18(23-15-24-19)12-16(17)6-4-2/h12-13H,3-11,14-15H2,1-2H3 |
| InChIKey | HHZWGSFIZRNPFB-UHFFFAOYSA-N |
| SMILES | CCCCOCCOCCOCc1cc2OCOc2cc1CCC |
| LogP (Verteilungskoeffizient) | 4.750 |
| CAS Datenbank | 51-03-6(CAS DataBase Reference) |
| NIST chemische Informationen | Piperonyl butoxide(51-03-6) |
| EPA chemische Informationen | Piperonyl butoxide (51-03-6) |
Sicherheit & Vorschriften
| GHS-Einstufung | WarningH319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]P261, P264+P265, P271, P273, P280, P304+P340, P305+P351+P338, P319, P337+P317, P391, P403+P233, P405, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for 1.8% (5 of 279) of reports.H319 (31.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] |
|---|---|
| Regulatorische Informationen | Chemical: 1,3-Benzodioxole, 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-1,3-Benzodioxole, 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,3-Benzodioxole, 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Piperonyl butoxide is listed in the dataset of EPA Human Health Benchmarks for Pesticides under the Safe Drinking Water Act (40 eCFR 141)Status: Active Update: 28-03-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/10134Piperonyl butoxide: HSNO Approval: HSR002869 Approved with controls |
| DOT-Kennzeichnung | Poison |
| Brandgefahren | This chemical is combustible. (NTP, 1992) |
| Brandpotenzial | Combustible when exposed to heat or flamecan react with oxidizing materials. |
| Gesundheitsgefahren | SYMPTOMS: Symptoms of exposure to this compound may include vomiting, diarrhea, anorexia and mild central nervous system depression. |
| Gefahrenübersicht | No listed effects of short-term or long-term exposure[ICSC] Skin absorption is limited, and mammalian toxicity is low[EPA Pesticides, p. 191] |
| FDA-Anforderungen | The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed over-the-counter drug products, incl piperonyl butoxide, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act.Drug products containing certain active ingredients offered over-the-counter (OTC) for certain uses. A number of active ingredients have been present in OTC drug products for various uses, as described below. However, based on evidence currently available, there are inadequate data to establish general recognition of the safety and effectiveness of these ingredients for the specified uses: the combination of pyrethrum extract (formerly named pyrethrins) and piperonyl butoxide in an aerosol dosage formulation is included in pediculicide drug products.Pediculicide active ingredients. The active ingredients of the product consist of the combination of pyrethrum extract (providing a concentration of pyrethrins of 0.17 to 0.33 percent) with piperonyl butoxide (2 to 4 percent) in a nonaerosol dosage formulation. |
| Reaktive Gruppe | Ethers |
| Special Reports | USEPA/Office of Pesticide ProgramsReregistration Eligibility Decision Document - Piperonyl Butoxide (PBO). EPA 738-R-06-005 (June 2006). The RED summarizes the risk assessment conclusions and outlines any risk reduction measures necessary for the pesticide to continue to be registered in the U.S.[Available from, as of October 7, 2009: http://www.epa.gov/pesticides/reregistration/status.htm]Bioassay of Piperonyl Butoxide for Possible Carcinogenicity (1979) Technical Rpt Series No. 120 DHEW Pub No. (NIH) 79-1375, U.S. Department of Health Education and Welfare, National Cancer Institute, Bethesda, MD 20014 |
| FIFRA-Anforderungen | Tolerances for residues of the insecticide piperonyl butoxide [(butyl carbityl)(6-propyl piperonyl)ether] are established in or on the following food commodities: [Table#3540]Piperonyl butoxide may be safely used in accordance with the following prescribed conditions: (i) It is used or intended for use in combination with pyrethrins for control of insects: (A) In cereal grain mills and in storage areas for milled cereal grain products, whereby the amount of piperonyl butoxide is at least equal to but not more than 10 times the amount of pyrethrins in the formulation. (B) On the outer ply of multiwall paper bags of 50 pounds or more capacity in amounts not exceeding 60 milligrams per square foot, whereby the amount of piperonyl butoxide is equal to 10 times the amount of pyrethrins in the formulation. Such treated bags are to be used only for food, dried. (C) On cotton bags of 50 pounds or more capacity in amounts not exceeding 55 milligrams per square foot of cloth, whereby the amount of piperonyl butoxide is equal to 10 times the amount of pyrethrins in the formulation. Such treated bags are constructed with waxed paper liners and are to be used only for food, dried that contain 4 percent fat or less. (D) In two-ply bags consisting of cellophane/polyolefin sheets bound together by an adhesive layer when it is incorporated in the adhesive. The treated sheets shall contain not more than 50 milligrams of piperonyl butoxide per square foot (538 milligrams per square meter). Such treated bags are to be used only for packaging plum, prune, driedgrape, raisinand other fruit, dried and are to have a maximum ratio of 3.12 milligrams of piperonyl butoxide per ounce of fruit (0.10 milligram of piperonyl butoxide per gram of product). (E) In food processing and food storage areas: Provided, That the food is removed or covered prior to such use.Piperonyl butoxide may be safely used in accordance with the following prescribed conditions: It is used or intended for use in combination with pyrethrins and N-octylbicycloheptene dicarboximide for insect control in accordance with 21 CFR 178.3730.Piperonyl butoxide may be safely used in accordance with the following prescribed conditions: A tolerance of 10 parts per million is established for residues of piperonyl butoxide in or on: (A) Grain, cereal, milled fractions when present therein as a result of its use in cereal grain mills and in storage areas for milled cereal grain products. (B) Food, dried when present as a result of migration from its use on the outer ply of multiwall paper bags of 50 pounds or more capacity. (C) Food treated in accordance with 21 CFR 178.3730. (D) Food, dried that contain 4 percent fat, or less, when present as a result of migration from its use on the cloth of cotton bags of 50 pounds or more capacity constructed with waxed paper liners. (E) Food treated in accordance with paragraph (a)(2)(i)(D) and (E) of this section.For more FIFRA Requirements (Complete) data for Piperonyl butoxide (13 total), please visit the HSDB record page. |
| Reactivity Profile | PIPERONYL BUTOXIDE can react with oxidizing materials. (NTP, 1992) |
| Air and Water Reactions | Insoluble in water. |
| Brandbekämpfung | Fires involving this material should be controlled using a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)Use foam, powder, carbon dioxide. |
| Erste-Hilfe-Maßnahmen | Fresh air, rest.Remove contaminated clothes. Rinse and then wash skin with water and soap.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Give one or two glasses of water to drink. Rest. Refer for medical attention . |
| Erste Hilfe | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. |
| Sichere Lagerung | Well closed. |
| Brandbekämpfungsverfahren | To fight fire, use foam, carbon dioxide, dry chemical. |
| Lagerbedingungen | Safe Storage of Pesticides. Always store pesticides in their original containers, complete with labels that list ingredients, directions for use, and first aid steps in case of accidental poisoning. Never store pesticides in cabinets with or near food, animal feed, or medical supplies. Do not store pesticides in places where flooding is possible or in places where they might spill or leak into wells, drains, ground water, or surface water. |
| Reinigungsverfahren | SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.This product is toxic to aquatic organisms, including fish and invertebrates. Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans or other waters unless in accordance with the requirements of a National Pollutant Discharge Elimination System (NPDES) permit and the permitting authority has been notified in writing prior to discharge. Do not discharge effluent containing this product to sewer systems without previously notifying the local sewage treatment plant authority. For guidance contact your State Water Board or Regional Office of the EPA. Do not contaminate water when disposing of equipment wash-waters.If a spill occurs, clean it up promptly. Don't wash it away. Instead, sprinkle the spill with sawdust, vermiculite, or kitty litter. Sweep it into a plastic garbage bag, and dispose of it as directed on the pesticide product label.After Applying a Pesticide, Indoors or Outdoors. To remove pesticide residues, use a bucket to rinse tools or equipment three times, including any containers or utensils that you used when mixing the pesticide. Then pour the rinsewater into the pesticide sprayer and reuse the solution by applying it according to the pesticide product label directions. After applying any pesticide wash your hands and any other parts of your body that may have come in contact with the pesticide. To prevent tracking pesticides inside, remove or rinse your boots or shoes before entering your home. Wash any clothes that have been exposed to a lot of pesticide separately from your regular wash. |
| Freisetung ohne Brand | SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. |
| Entsorgungsverfahren | SRP: Criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.Safe Disposal of Pesticides. The best way to dispose of small amounts of excess pesticides is to use them - apply them - according to the directions on the label. If you cannot use them, ask your neighbors whether they have a similar pest control problem and can use them. If all of the remaining pesticide cannot be properly used, check with your local solid waste management authority, environmental agency, or health department to find out whether your community has a household hazardous waste collection program or a similar program for getting rid of unwanted, leftover pesticides. These authorities can also inform you of any local requirements for pesticide waste disposal.Safe Disposal of Pesticides. An empty pesticide container can be as hazardous as a full one because of residues left inside. Never reuse such a container. When empty, a pesticide container should be rinsed carefully three times and the rinsewater thoroughly drained back onto the sprayer or the container previously used to mix the pesticide. Use the rinsewater as a pesticide, following label directions. Replace the cap or closure securely. Dispose of the container according to label instructions. Do not puncture or burn a pressurized container like an aerosol - it could explode. Do cut or puncture other empty pesticide containers made of metal or plastic to prevent someone from reusing them. Wrap the empty container and put it in the trash after you have rinsed it. |
| Verschüttetes entsorgen | Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment. |
| Preventive Measures | SRP: Contaminated protective clothing should be segregated in a manner that results in no direct personal contact by personnel who handle, dispose of, or clean the clothing. Quality assurance procedures to confirm the efficacy of the cleaning procedures should be implemented prior to the decontaminated protective clothing being returned for reuse by the workers. Contaminated clothing (including shoes/socks) should not be taken home at end of shift, but should remain at employee's place of work for cleaning.Users should wash hands before eating, drinking, chewing gum, using tobacco, or using the toilet. Users should remove clothing/PPE immediately if pesticide gets inside. Then wash thoroughly and put on clean clothing. Users should remove PPE immediately after handling this product. Wash the outside of gloves before removing. As soon as possible, wash thoroughly and change into clean clothing.Follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions for washables exist, use detergent and hot water. Keep and wash PPE separately from other laundry. Discard clothing and other absorbent material that have been drenched or heavily contaminated with the product's concentrate. Do not reuse them.Do not apply directly to water, to areas where surface water is present or to intertidal areas below the mean high water mark. Do not contaminate water when disposing of equipment wash-waters or rinsate.For more Preventive Measures (Complete) data for Piperonyl butoxide (8 total), please visit the HSDB record page. |
| Isolation and Evacuation | Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: |
| Wechselwirkungen | Inhibition of metab of drugs has also been demonstrated ... Piperonyl butoxide competitively inhibits n-demethylation of ethylmorphine and o-demethylation of p-nitroanisole...... Mouse trials indicate that it can dramatically incr toxicity of freons and griseofulvin or vice versa.In the case of certain sulfur-containing organophosphorus insecticides, which require metabolic activation ... /it is/ antagonistic to development of normal insecticidal potency.Pyrethrin synergists such as piperonyl butoxide ... are effective for DDT, ...for carbamates, ... and for diazinon, trichlorfon, and other phosphates, ... but they are antagonistic for malathion ...For more Interactions (Complete) data for Piperonyl butoxide (11 total), please visit the HSDB record page. |
| Ökotoxizitätswerte | LC50Species: Anas platyrhynchos (Mallard duck, age 10 days) diet >5620 ppm for 8 daysSpecies: Colinus virginianus (Northern bobwhite, age 10 days) diet >5620 ppm for 8 daysLD50Species: Colinus virginianus (Northern bobwhite, age 39 weeks) oral via capsule >2250 mg/kgSpecies: Coturnix japonica (Japanese quail, 14 days old) oral (5 day ad libitum in diet) >5,000 ppm /Technical grade, 100% active ingedient/For more Ecotoxicity Values (Complete) data for Piperonyl butoxide (38 total), please visit the HSDB record page. |
| Umweltverhalten | TERRESTRIAL FATE: Based on a classification scheme(1), Koc values ranging from 399-830(2) indicate that piperonyl butoxide is expected to have moderate to low mobility in soil(SRC). Volatilization of piperonyl butoxide from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 8.9X10-11 atm-cu m/mole(SRC), using a fragment constant estimation method(3). Piperonyl butoxide is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 5.2X10-6 mm Hg at 25 °C(SRC), determined from a fragment constant method(4). A half-life in aerobic soils of 14 days(2) suggests that biodegradation may be an important environmental fate process in soil(SRC).AQUATIC FATE: Based on a classification scheme(1), Koc values ranging from 399-830(2) indicate that piperonyl butoxide is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 8.9X10-11 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 27(SRC), from a log Kow of 4.75(2) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). A half-life in aerobic soils of 14 days(2) suggests that biodegradation may be an important environmental fate process in water(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), piperonyl butoxide, which has an estimated vapor pressure of 2.6X10-7 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase piperonyl butoxide is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 3.6 hours(SRC), calculated from its rate constant of 1.1X10-10 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase piperonyl butoxide may be removed from the air by wet or dry deposition(SRC). Piperonyl butoxide contains chromophores that absorb at wavelengths >290 nm(4) and therefore may be susceptible to direct photolysis by sunlight(SRC)it was rapidly degraded (half-life 8.4 hours) in aqueous solution when illuminated with sunlight(5). |
| Lebensmitteluntersuchungswerte | In a study in which 531 samples of grain and beans from the U.S., Japan, Australia, Korea, Canada and other countries were analyzed, the following food products detected piperonyl butoxide: 3 wheat from the U.S. (max concentraion 1.4 ppm)1 barley from the U.S. (0.8 ppm)2 barley from Australia (max concn 1.4 ppm)it was not detected (0.1 ppm detection limit) in hulled and unhulled rice, buck wheat, rye, oats, corn, milo, soy beans or red beans(1). Piperonyl butoxide was identified, not quantified (0.20 ppm limit of quantitation), in domestic and imported pears(2). Piperonyl butoxide was detected in 46 out of 769 domestic apples at a max concentration of 1.6 ppm and in 52 out of 1,062 imported apples at a maximum concentration of 0.47 ppm(3). The NY State Department of Agriculture detected piperonyl butoxide in three sweet potato samples at concentrations of 0.0003, 0.00017 and 0.007 ppm(4). |
| Unerwünschte Wirkungen | Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation. |
| Expositionspfade | The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. |
| Ökotoxizitätsauszüge | /BIRDS and MAMMALS/ PBO is practically nontoxic to birds on an acute basis. There were no mortalities observed at the highest concentration tested for acute oral (2250 mg/kg bw) or for the sub-acute dietary studies (5620 ppm). EPA did not calculate Reportable Quantities from the acute toxicity data because no mortality was seen at very high concentrations indicting minimal adverse acute effects to birds. From chronic avian toxicity data, a NOEC of 300 ppm was estimated from an avian reproduction study in which adult and hatchling body weight and food consumption, number of eggs laid, number of eggs cracked, and eggshell thickness effects were observed at the lowest observed effect concentration (LOEC) of 1200 ppm./AQUATIC SPECIES/ Freshwater Fish. PBO is moderately toxic to freshwater fish on an acute basis (LC50 = 1.9 ppm). A no observed effect concentration (NOEC) of 0.04 ppm was estimated from a chronic early life stage of fish study with fathead minnow in which embryo survival at hatch and length and weight of larvae was observed at the lowest observed effect concentration (LOEC) of 0.11 ppm. Freshwater invertebrates. PBO ranges from moderately toxic (LC50 = 12.0 ppm) to highly toxic (LC50 = 0.51 ppm) to freshwater invertebrates on an acute basis. The species selected for RQ calculation was Daphnia magna with an LC50 of 0.51 ppm. A NOEC of 0.030 ppm was estimated from a chronic life cycle study where Daphnia magna exhibited reproduction affects at the lowest observed effect concentration (LOEC) of 0.047 ppm. Estuarine fish. PBO is moderately toxic (LC50 = 3.94 ppm) to estuarine/marine fish based on observed effects to sheepshead minnow on an acute basis. There are no chronic data available for estuarine fish. Estuarine/Marine invertebrates. PBO is highly toxic to estuarine invertebrates (LC50 = 0.49 ppm). There are no chronic data available for estuarine/marine invertebrates. Amphibians. PBO is highly toxic to amphibians on an acute basis (LC50 = 0.21 ppm)./AQUATIC SPECIES/ Freshwater Fish. Fathead minnow (Pimephales promelas). Exposure scenario: Chronic. NOEC= 0.04 ppm, LOEC = 0.11 ppm. Effect: Survival and growth /from table//AQUATIC SPECIES/ Freshwater Invertebrates. Waterflea (Daphnia magna). NOEC = 0.03 ppm LOEC = 0.047 ppm. Effect: reproduction Exposure scenario chronic. /from table/For more Ecotoxicity Excerpts (Complete) data for Piperonyl butoxide (9 total), please visit the HSDB record page. |
| Signs and Symptoms | Diarrhoea. Vomiting. |
| Acute Toxicity Link | Chemical: PIPERONYL BUTOXIDE |
| Ongoing Test Status | The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical.[Available from: http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=51-03-6] |
| Effluent Concentrations | Piperonyl butoxide was not detected in runoff water following application of a multi-purpose insecticide containing this compound(1). |
| ICSC Environmental Data | The substance is very toxic to aquatic organisms. Bioaccumulation of this chemical may occur in seafood. |
| Wassergefährdungsklasse (WGK) | 3 |
| TSCA-Inventar-Status | TSCA listed |
| UN-Transportnummer | UN 3082 9/PG 3 |
| Zollcode | 29329990 |
| RTECS-Nr. | XS8050000 |
| R-Sätze (R) | 50/53-51/53-24 |
| Toxizität | LD50 orally in female, male rats: 6150, 7500 mg/kg (Gaines) |
| Gefahrensymbole | N,T |
| Sicherheitshinweise (S) | 60-61-45-36/37/39-28A |
| Gefahrenklasse | 6.1(b)Aquatic Acute 1Aquatic Chronic 1Eye Irrit. 2STOT SE 3 |
| Verpackungsgruppe | III |
| Lagerklasse | 10 - Combustible liquids |
| Gefahrstoffdaten | 51-03-6(Hazardous Substances Data) |
Anwendungen & Verwendung
Beschreibung
Piperonyl butoxide (PBO) is a water insoluble colorless to pale yellow liquid that was developed in the 1940s to increase the effectiveness of various pesticides. It is currently registered as an active ingredient in more than 1500 products used for indoor or outdoor pesticides, including agricultural maintenance of some food crops.
Verwenden
Piperonyl butoxide is used as a synergist for pyrethrins and their synthetic analogues. It is typically added to carbamate, pyrethrin, pyrethroid, and rotenone pesticides to greatly enhance their potency. PBO alone does not have pesticidal properties.
Herstellung & Synthese
synthetische
First, safrole is obtained from allyl chloride and methylenedioxybenzene. Then, piperonyl butoxide is produced by catalytic hydrogenation, chloromethylation, and etherification reactions.