Grundinformationen
- CAS
51-05-8- Standard-SMILES
CCN(CC)CCOC(=O)c1ccc(N)cc1.Cl- InChIKey
HCBIBCJNVBAKAB-UHFFFAOYSA-N- Summenformel
- C13H21ClN2O2
- Durchschnittliche Molmasse
- 272,77 g/mol
- Monoisotopische Masse
- 272,1291556
Überblick
Procaine hydrochloride is an organic molecular entity.
Namen und Bezeichner
- Bevorzugter Name
- Procaine Hydrochloride
- IUPAC
- 2-(diethylamino)ethyl 4-aminobenzoate;hydrochloride
- Lokaler Name
- Procainhydrochlorid
- Englischer Name
- Procaine hydrochloride
- Summenformel
- C13H21ClN2O2
- Molmasse
- 272.77
Namen und Synonyme
PROCAINE HYDROCHLORIDE51-05-8Procaine HclNaucaineNeocaineOmnicainPlanocaineAnestilJenacaineMedajectSyntocainRocain
Weitere Namen anzeigen
NOVOCAINE HYDROCHLORIDEPROCAIN HYDROCHLORIDEsyncainejuvocainebernocainechlorocainediethylaminoethanol4-aminobenzoatehydrochloridecetain
EnproBenzoic acid, 4-amino-, 2-(diethylamino)ethyl ester, monohydrochlorideDTXSID104443595URV01IDQSP01ANSC-757280SP-01AProcaini hydrochloridum
Datenbank-Bezeichner
- CAS
51-05-8- PubChem CID
- 5795
- DTXSID
DTXSID1044435- ChEMBL
CHEMBL1200841- ChEBI
CHEBI:8431- UNII
- 95URV01IDQ
- EC Number
- 200-077-2
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 55,6 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 4
- Frei drehbare Bindungen
- 7
- Schwere Atome
- 18
- Formalladung
- 0
- Komplexität
- 221
Experimentelle und physikochemische Eigenschaften
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Animal DrugsPharmaceuticals -> UK Veterinary Medicines Directorate List
Physikochemische Eigenschaften
- Schmelzpunkt
- 155 · 155-156 °C(lit.)
- Siedepunkt
- 195 · 195-196°C 17mm
- Dichte
- 1.1761 · 1.1761 (rough estimate)
- Brechungsindex
- 1.527 · 1.5270 (estimate)
- Flammpunkt
- 195 · 195-196°C/17mm
- storage temp.
- 2 · 2-8°C
- Löslichkeit
- 20 mg/mlDMSO: · DMF: 20 mg/mlDMSO: 14 mg/mlEthanol: 16 mg/mlPBS (pH 7.2): 10 mg/ml
- Aggregatzustand
- Crystals or Crystalline Powder
- Farbe
- Colorless to white
- Wasserlöslichkeit
- soluble
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
This chemical does not meet GHS hazard criteria for 0.6% (1 of 158) of reports.
Danger
H301 (99.4%): Toxic if swallowed [Danger Acute toxicity, oral]
P203, P260, P261, P264, P264+P265, P270, P272, P280, P301+P316, P302+P352, P305+P351+P338, P308+P316, P318, P321, P330, P333+P317, P337+P317, P362+P364, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 158 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Regulatory Information
REACH registered substance: Procaine hydrochloride (EC: 200-077-2)
Procaine hydrochloride: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - Benzoic acid, 4-amino-, 2-(diethylamino)ethyl ester, monohydrochloride: Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 3 (99.4%)
Toxikologische Informationen
Exposure RoutesOral, Infiltration, Intramuscular
Toxicity Summary
Procaine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited. The receptor site is thought to be located at the cytoplasmic (inner) portion of the sodium channel. Procaine has also been shown to bind or antagonize the function of N-methyl-D-aspartate (NMDA) receptors as well as nicotinic acetylcholine receptors and the serotonin receptor-ion channel complex.
Chemie und Industrie
Pharmakologische Informationen
Metabolism/MetabolitesHydrolysis by plasma esterases to PABA
Route of Elimination: With normal kidney function, the drug is excreted rapidly by tubular excretion.
Half Life: 7.7 minutes
MeSH Pharmacological Classification
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
Verwendung und Herstellung
UsesIt is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. [Wikipedia]
General Manufacturing InformationBenzoic acid, 4-amino-, 2-(diethylamino)ethyl ester, hydrochloride (1:1): ACTIVE
Anwendungen
BeschreibungProcaine hydrochloride, also called Novocain, or Novocaine, a topical anesthetic, which can block the nerve fiber conduction temporarilyand has a narcotic effect,strong effect, low toxicity, and non-addictive, but on the skin, mucosal penetration is weak, unsuitable for surface anesthesia, patients are used for infiltration, conduction and spinal anesthesia.The structure of procaine hydrochloride with aromatic primary amino, easy oxidation discoloration pH, temperature, UV, oxygen and metal ions can accelerate the oxidation discoloration. The aqueous solution was stable in pH3.0~5. So preparation of procaine hydrochloride injection, it generally takes add acid to regulate pH 3.3 to 5.5, and strictly control the sterilization temperature and time. to 100 ℃ steam sterilization 30min circulation is appropriate, and should pay attention to shading, sealed save.The above information is edited by the chemicalbook of Kui Xiongfeng.
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