CK-666
Grundinformationen
- CAS
442633-00-3- Standard-SMILES
Cc1[nH]c2ccccc2c1CCNC(=O)c1ccccc1F- InChIKey
UXRKUKRXVWJFER-UHFFFAOYSA-N- Summenformel
- C18H17FN2O
- Durchschnittliche Molmasse
- 296,3 g/mol
- Monoisotopische Masse
- 296,13249133
Überblick
CK-666 is a member of the class of indoles that is 2-methyltryptamine in which a hydrogen attached to the primary amino group has been replaced by a 2-fluorobenzoyl group. It is a cell-permeable inhibitor of actin assembly mediated by actin-related protein Arp2/3 complex which works by binding to Arp2/3 complex, stabilising the inactive state of the complex and preventing its movement into the active conformation. It has a role as an actin polymerisation inhibitor. It is a member of benzamides, a member of indoles and an organofluorine compound.
Namen und Bezeichner
- Bevorzugter Name
- CK-666
- IUPAC
- 2-fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide
- Englischer Name
- 2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide
- Summenformel
- C18H17FN2O
- Molmasse
- 296.34
Namen und Synonyme
CK-666CK-0944666CHEBI:78843RefChem:918753442633-00-32-fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamideCK 6662-Fluoro-N-(2-(2-methyl-1H-indol-3-yl)ethyl)benzamideMFCD030362713ukrUXRKUKRXVWJFER-UHFFFAOYSA-NOprea1_850670
Weitere Namen anzeigen
CK-666 ，S7690CK 666 (CK 0944666)CK-666, 10 mM in DMSOArp2/3 Complex Inhibitor I, CK-666CK 666, Actin polymerization inhibitor2-Fluoro-N-[2-(2-methyl-3-indolyl)ethyl]benzamideBenzamide, 2-fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-
orb1309829SCHEMBL3382638SCHEMBL29576885DTXSID703433302-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)-ethyl]-benzamideCK666SSA63300NSC821559
Datenbank-Bezeichner
- CAS
442633-00-3- PubChem CID
- 589075
- DTXSID
DTXSID70343330
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 3,8
- Polarare Oberfläche (TPSA)
- 44,9 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 2
- Frei drehbare Bindungen
- 4
- Schwere Atome
- 22
- Formalladung
- 0
- Komplexität
- 389
Physikochemische Eigenschaften
- Siedepunkt
- 528.2 · 528.2±50.0 °C(Predicted)
- Dichte
- 1.235 · 1.235±0.06 g/cm3(Predicted)
- storage temp.
- 2 · 2-8°C
- Löslichkeit
- 25 mg/mL · DMSO: ≥25mg/mL
- pka
- 13.86 · 13.86±0.46(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to tan
- Stabilität
- 1 year · Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
- InChI
- 1S/C18H17FN2O/c1-12-13(14-6-3-5-9-17(14)21-12)10-11-20-18(22)15-7-2-4-8-16(15)19/h2-9,21H,10-11H2,1H3,(H,20,22)
- InChIKey
- UXRKUKRXVWJFER-UHFFFAOYSA-N
- SMILES
- Cc1[nH]c2ccccc2c1CCNC(=O)c3ccccc3F
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
P264+P265, P280, P305+P351+P338, and P337+P317 (click each P-code to see the statement)
Aggregated GHS information provided per 38 reports by companies from 1 notifications to the ECHA C&L Inventory.
Gefahrenhinweise
Hazard Classes and CategoriesEye Irrit. 2 (100%)
Sicherheitsdaten
- wgk
- 3
- risk_code
- 36
- hazard_code
- Xi
- safety_code
- 26
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Anwendungen
VerwendenCK-666 may be used to study Arp2/3-mediated structural changes in cells.
Anbieter37 Anbieter
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
广东云星生物技术有限公司0751-18902340975/189023400307 18902340307 · [email protected]
韶远科技（上海）有限公司4000665055 · [email protected]
United Life Science020-82099279 18988968278 · [email protected]
河南阿尔法化工有限公司0371-55013243 15324716602 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
怀化市冰峰化工有限公司0745-2866851 17711757908 · [email protected]
上海瀚香生物科技有限公司177-54423994 17754423994 · [email protected]
湖北魏氏化学试剂股份有限公司17771898297 13125137661 · [email protected]
南京杜莱生物技术有限公司025-84699383-8003;025-846993838003-8003 18013301590 · [email protected]
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