Grundinformationen
- CAS
54-71-7- Standard-SMILES
CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C.Cl- InChIKey
RNAICSBVACLLGM-GNAZCLTHSA-N- Summenformel
- C11H17ClN2O2
- Durchschnittliche Molmasse
- 244,72 g/mol
- Monoisotopische Masse
- 244,09785546
Überblick
Pilocarpine hydrochloride is the hydrochloride salt of (+)-pilocarpine, a medication used to treat increased pressure inside the eye and dry mouth. It contains a (+)-pilocarpine.
Namen und Bezeichner
- Bevorzugter Name
- Pilocarpine Hydrochloride
- IUPAC
- (3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one;hydrochloride
- Lokaler Name
- Pilocarpinhydrochlorid
- Englischer Name
- (+)-Pilocarpine hydrochloride
- Summenformel
- C11H17ClN2O2
- Molmasse
- 244.72
Namen und Synonyme
Pilocarpine hydrochloride54-71-7Pilocarpine HClSalagenPilocarpine monohydrochlorideSno piloIsopto carpineVistacarpin NPILOPINE HSPilopineQLOSIVUITY
Weitere Namen anzeigen
(3S,4R)-4,5-DIHYDRO-3-ETHYL-4-(1-METHYL-1H-IMIDAZOL-5-YLMETHYL)-2(3H)-FURANONE HYDROCHLORIDESanpilopilocarpilocel(3S,4R)-Akarpineami-pilo
Pilocarpinum muriaticum0WW6D218XJNSC5746CHEBI:141029Pilocarpini hydrochloridumDTXSID2041096(3S,4R)-3-ethyl-4-((1-methyl-1H-imidazol-5-yl)methyl)dihydrofuran-2(3H)-one hydrochloride2(3H)-Furanone, 3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-, monohydrochloride, (3S,4R)-
Datenbank-Bezeichner
- CAS
54-71-7- PubChem CID
- 5909
- DTXSID
DTXSID2041096- ChEMBL
CHEMBL1200330、CHEMBL611494- ChEBI
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 44,1 Ų
- H-Brücken-Donoren
- 1
- H-Brücken-Akzeptoren
- 3
- Frei drehbare Bindungen
- 3
- Schwere Atome
- 16
- Formalladung
- 0
- Komplexität
- 245
Experimentelle und physikochemische Eigenschaften
Solubility>36.7 [ug/mL] (The mean of the results at pH 7.4)
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Physikochemische Eigenschaften
- Schmelzpunkt
- 202 · 202-205 °C(lit.)
- storage temp.
- 2 · 2-8°C
- Löslichkeit
- 2 O: · H2O: 100 mg/mL
- Aggregatzustand
- powder
- Farbe
- white
- Wasserlöslichkeit
- soluble
- Merck
- 14 · 14,7424
- BRN
- 4034491 · 4034491
- Stabilität
- Hygroscopic
- Major Application
- forensics and toxicologyveterinary
- InChI
- 1S/C11H16N2O2.ClH/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;/h5,7-8,10H,3-4,6H2,1-2H3;1H/t8-,10-;/m0./s1
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Danger
H300 (64.2%): Fatal if swallowed [Danger Acute toxicity, oral]
P260, P264, P270, P271, P284, P301+P316, P304+P340, P316, P320, P321, P330, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 123 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Regulatory InformationPilocarpine hydrochloride: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - 2(3H)-Furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, monohydrochloride, (3S-cis)-: Human health tier I assessment
Hazard Classes and CategoriesAcute Tox. 2 (64.2%)
Toxikologische Informationen
Treatment
Overdosage should be treated with atropine titration (0. 5 mg to 1. 0 mg given subcutaneously or intravenously) and supportive measures to maintain respiration and circulation. Epinephrine (0. 3 mg to 1. 0 mg, subcutaneously or intramuscularly) may also be of value in the presence of severe cardiovascular depression or bronchoconstriction. (L1712)
Exposure RoutesOral ; eye contact. There was a decrease in the rate of absorption of pilocarpine from SALAGEN Tablets when taken with a high fat meal by 12 healthy male volunteers
Chemie und Industrie
Pharmakologische Informationen
Metabolism/MetabolitesPossibly occurs at the neuronal synapses and in the plasma
Half Life: 0.76 hours
FDA Pharmacological Classification
PILOCARPINE HYDRCHLORIDE
Cholinergic Agonists [MoA]; Cholinergic Receptor Agonist [EPC]; Cholinergic Muscarinic Agonists [MoA]
PILOCARPINE HYDROCHLORIDE
Cholinergic Agonists [MoA]; Cholinergic Receptor Agonist [EPC]; Cholinergic Muscarinic Agonists [MoA]
PILOCARPINE HYDROCHLORIDE OPHTHALMIC SOLUTION
Cholinergic Muscarinic Agonists [MoA]; Cholinergic Receptor Agonist [EPC]; Cholinergic Agonists [MoA]
MeSH Pharmacological Classification
Agents causing contraction of the pupil of the eye. Some sources use the term miotics only for the parasympathomimetics but any drug used to induce miosis is included here.
Drugs that bind to and activate muscarinic cholinergic receptors (RECEPTORS, MUSCARINIC). Muscarinic agonists are most commonly used when it is desirable to increase smooth muscle tone, especially in the GI tract, urinary bladder and the eye. They may also be used to reduce heart rate.
Verwendung und Herstellung
UsesFor the treatment of radiation-induced dry mouth (xerostomia) and symptoms of dry mouth in patients with Sjögrens syndrome.
General Manufacturing Information2(3H)-Furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, hydrochloride (1:1), (3S,4R)-: ACTIVE
Anwendungen
Verwenden(+)-Pilocarpine hydrochloride is a muscarinic M1 and M2 acetylcholine receptor agonist with pKB values of 5 and 3.7, respectively. Systemic administration of (+)-Pilocarpine hydrochloride is typically used as an animal model for temporal lobe epilepsy and can mimic the generation of complex partial seizures by producing changes in hippocampal neuron morphology, membrane properties, and synaptic responses.
Zugehörige Reaktionen
3
Notizen zur Verbindung
Wird geladen…