Grundinformationen
- CAS
55-97-0- Standard-SMILES
C[N+](C)(C)CCCCCC[N+](C)(C)C.[Br-].[Br-]- InChIKey
FAPSXSAPXXJTOU-UHFFFAOYSA-L- Summenformel
- C12H30Br2N2
- Durchschnittliche Molmasse
- 362,19 g/mol
- Monoisotopische Masse
- 360,07757
Überblick
See also: Hexamethonium (has active moiety); Hexamethonium Chloride (related); Hexamethonium Iodide (related).
Namen und Bezeichner
- Bevorzugter Name
- Hexamethonium Bromide
- IUPAC
- trimethyl-[6-(trimethylazaniumyl)hexyl]azanium dibromide
- Lokaler Name
- Hexamethoniumbromid
- Englischer Name
- HEXAMETHONIUM BROMIDE
- Summenformel
- C12H30Br2N2
- Molmasse
- 362.19
Namen und Synonyme
HEXAMETHONIUM BROMIDE55-97-0Bistrium bromideBromuro de hexametonioBromure d'hexamethoniumEsametonio bromuroHexamethonii bromidum1,6-Hexanediaminium, N,N,N,N',N',N'-hexamethyl-, dibromideHEXAMETHONE BROMIDE8J77X3S603NSC-163965alpha, omega-Bis(trimethyl ammonium)hexane dibromide
Weitere Namen anzeigen
HEXAMETHONIUM DIBROMIDEN1,N1,N1,N6,N6,N6-hexamethylhexane-1,6-diaminium bromidehexametonvegolysenvegolysinesametinagangliostatMethobrominesimpatoblockhexoniumdibromide
DTXSID50883229NSC163965Bromide, HexamethoniumhexamAthonium (cation)RefChem:786199DTXCID801022778benzohexonium (for the benzosulfonate)200-249-7
Datenbank-Bezeichner
- CAS
55-97-0
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 0 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 2
- Frei drehbare Bindungen
- 7
- Schwere Atome
- 16
- Formalladung
- 0
- Komplexität
- 121
Experimentelle und physikochemische Eigenschaften
Physical DescriptionLiquid
Physikochemische Eigenschaften
- Schmelzpunkt
- 285 °C · ~285 °C (dec.)
- storage temp.
- Inert atmosphere,Room Temperature
- Löslichkeit
- Water (Slightly)
- Aggregatzustand
- Crystalline Powder and Agglomerates
- Farbe
- White
- PH
- pH (20g/l, 25℃) : 4.5～6.5
- Wasserlöslichkeit
- 2 O: · H2O: 100mg/mL
- Merck
- 14 · 14,4688
- BRN
- 3715749 · 3715749
- InChI
- InChI=1S/C12H30N2.2BrH/c1-13(2,3)11-9-7-8-10-12-14(4,5)6;;/h7-12H2,1-6H3;2*1H/q+2;;/p-2
- InChIKey
- FAPSXSAPXXJTOU-UHFFFAOYSA-L
- SMILES
- C(CCCCC[N+](C)(C)C)[N+](C)(C)C.[Br-].[Br-]
- CAS Datenbank
- 55 · 55-97-0(CAS DataBase Reference)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
This chemical does not meet GHS hazard criteria for 88.9% (8 of 9) of all reports.
Danger
H370 (11.1%): Causes damage to organs [Danger Specific target organ toxicity, single exposure]
P260, P264, P270, P308+P316, P321, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 9 reports by companies from 2 notifications to the ECHA C&L Inventory.
Gefahrenhinweise
Regulatory Information
1,6-Hexanediaminium, N1,N1,N1,N6,N6,N6-hexamethyl-, bromide (1:2) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,6-Hexanediaminium, N1,N1,N1,N6,N6,N6-hexamethyl-, bromide (1:2) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.
REACH registered substance: Hexamethonium bromide (EC: 200-249-7)
Hazard Classes and CategoriesSTOT SE 1 (11.1%)
Sicherheitsdaten
- wgk
- 2
- tsca
- TSCA listed
- hs_code
- 29239000
- RTECS-Nr.
- BQ8575000
- safety_code
- 22-24/25
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Agents having as their major action the interruption of neural transmission at nicotinic receptors on postganglionic autonomic neurons. Because their actions are so broad, including blocking of sympathetic and parasympathetic systems, their therapeutic use has been largely supplanted by more specific drugs. They may still be used in the control of blood pressure in patients with acute dissecting aortic aneurysm and for the induction of hypotension in surgery.
Drugs that bind to nicotinic cholinergic receptors (RECEPTORS, NICOTINIC) and block the actions of acetylcholine or cholinergic agonists. Nicotinic antagonists block synaptic transmission at autonomic ganglia, the skeletal neuromuscular junction, and at central nervous system nicotinic synapses.
Verwendung und Herstellung
U.S. Production2023: 250,000 - <550,000 lb
Industry UsesProcessing aids not otherwise specified
General Manufacturing Information
All Other Basic Organic Chemical Manufacturing
1,6-Hexanediaminium, N1,N1,N1,N6,N6,N6-hexamethyl-, bromide (1:2): ACTIVE
Anwendungen
BeschreibungHexamethonium is a peripherally-acting nondepolarizing neuromuscular blocking agent that acts as an antagonist of nicotinic acetylcholine receptors (nAChRs). It decreases acetylcholine release induced by carbamoylcholine in isolated cat superior cervical ganglion when used at concentrations of 27.4 and 54.8 μg/ml. It also decreases mean arterial pressure in unanesthetized rats when administered at a dose of 40 mg/kg. Intraventricular administration of hexamethonium (18 ng, i.c.v.) induces signs of nicotine abstinence, including shaking, writhing, and chewing in nicotine-dependent rats. Formulations containing hexamethonium were previously used in the treatment of hypertension.
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