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HCID 5951Erstellt: 27. Oktober 2026

L-Serine

L-SERINE F · Brn 1721404 · L-SERINE F, USP · Cysteine Impurity B · Cysteine hydrochloride EP Impurity B · 2-Amino-3-hydroxypropanoic acid, (S)- · (2S)-2-amino-3-hydroxy-propanoic acid

https://huagongshe.com/de/chemical/5951

Molekülstruktur von L-Serine

Identifikatoren & physikalische Daten

CAS No.302-84-1
SummenformelC3H7NO3
Durchschnittliche Molmasse105,09 g/mol
Monoisotopische Masse105,04259308 g/mol
SMILESN[C@@H](CO)C(=O)O
InChIKeyMTCFGRXMJLQNBG-REOHCLBHSA-N
PubChem CID5951
ChEMBLCHEMBL11298
ChEBICHEBI:17115
EC No.200-274-3
DTXSIDDTXSID301031857

Chemische & physikalische Eigenschaften

XLogP-3,1
Polarare Oberfläche (TPSA)83,6
H-Brücken-Donoren3
H-Brücken-Akzeptoren4
Frei drehbare Bindungen2
Schwere Atome7
Formalladung0
Komplexität72,6
StoffklassenBiological Agents -> Amino Acids and Derivatives
ArzneimittelPharmaceuticals -> Listed in ZINC15
KosmetikaCosmetic ingredients (Serine) -> CIR (Cosmetic Ingredient Review)Hair conditioningAntistaticSkin conditioning
LogP (Verteilungskoeffizient)LogP = -3.07
GeschmackSWEETISH TASTE, INSIPID AFTERTASTE
LebensmittelzusatzstoffeFLAVOR ENHANCER, FLAVORING AGENT OR ADJUVANT, NUTRIENT SUPPLEMENT -> FDA Substance added to food
Dichte1.6 g/cu cm @ 22 °C
Color/FormHEXAGONAL PLATES OR PRISMSCOLORLESS CRYSTALS
LöslichkeitSOL IN WATERPRACTICALLY INSOL IN ABSOLUTE ALCOHOL, ETHERINSOL IN BENZENE, ETHER, ETHANOLWater solubility = 425 g/L at 25 °C425.0 mg/mL
Schmelzpunkt228 °C (decomposes)
Dampfdruck0.00000004 [mmHg]
Optical RotationSPECIFIC OPTICAL ROTATION: -6.83 DEG @ 20 °C/D (1.5 G IN 15 G AQ SOLN)+14.45 DEG @ 25 °C/D (C= 0.5 G IN 5.6 NORMAL HCL)

Sicherheit & Vorschriften

GHS-EinstufungThis chemical does not meet GHS hazard criteria for 94% (236 of 251) of all reports.Not ClassifiedAggregated GHS information provided per 251 reports by companies from 6 notifications to the ECHA C&L Inventory.
Regulatorische InformationenChemical: L-SerineStatus: Active Update: 07-07-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/5558Serine: Does not have an individual approval but may be used under an appropriate group standardL-serine: Does not have an individual approval but may be used under an appropriate group standard
Weitere SicherheitsinformationenIMAP assessments - L-Serine: Environment tier I assessment
GefahrenübersichtDoes not appear to reach the fetus of pregnant pigs (placenta metabolizes to glycine)Small increase in resorptions observed in rats following intraperitoneal treatment[REPROTOX]
FDA-AnforderungenManufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended21 U.S.C. 321-392).
Hazard Classes and CategoriesNot Classified
EntsorgungsverfahrenSRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
WechselwirkungenINTRACEREBROVENTRICULAR INJECTIONS OF ALANINE (0.5-2.0 UG) INTO RABBITS CAUSED DECR IN BODY TEMP IN A 10-DEG ENVIRONMENT. THE EFFECT WAS SLIGHTLY SUBADDITIVE WITH THAT OF SERINE.ERYTHROBLASTIC LEUKEMIC CELLS INCUBATED IN MEDIA CONTAINING ESSENTIAL AMINO ACID L-SERINE BOUND APPROX 30% MORE INSULIN LABELED WITH (125)IODINE THAN THOSE INCUBATED WITHOUT SERINE.
Toxizitätsübersicht
Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.orgL-Serine plays a role in cell growth and development (cellular proliferation). The conversion of L-serine to glycine by serine hydroxymethyltransferase results in the formation of the one-carbon units necessary for the synthesis of the purine bases, adenine and guanine. These bases when linked to the phosphate ester of pentose sugars are essential components of DNA and RNA and the end products of energy producing metabolic pathways, ATP and GTP. In addition, L-serine conversion to glycine via this same enzyme provides the one-carbon units necessary for production of the pyrimidine nucleotide, deoxythymidine monophosphate, also an essential component of DNA.
Natural Pollution SourcesNATURALLY OCCURRING FORM IS L-SERINE.
Human Toxicity ExcerptsHUMAN NEUROBLASTOMA SK-N-SH-SY5Y (5Y) CELLS WERE CULTURED WITH SUPPLEMENTAL SERINE FOR 3-6 DAYS. SERINE HYDROXYMETHYLTRANSFERASE WAS ASSAYED. NO CHANGES IN SPECIFIC ACTIVITY OR CELLULAR MORPHOLOGY WERE NOTED @ CONCN LESS THAN 16 UMOL.METABOLIC EFFECTS OF CONTROLLED MODIFIED INTAKES OF L-SERINE IN PARENTERAL NUTRITION SOLUTIONS WERE INVESTIGATED IN NORMAL ADULTS.
Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).
Non-Human Toxicity ExcerptsADMIN TO RATS ON DAYS 8-14 OF PREGNANCY, VARIOUS AMINO ACIDS INCL SERINE INCR % RESORPTIONS FROM CONTROL VALUE OF 1.85% TO 5.36-8.85%. ADMIN IP AT 0.1 ML 0.3 MOLAR SOLN/DAY.RAT GLIOMA CELLS (C6) CULTURED WITH SUPPLEMENTAL SERINE FOR 3-6 DAYS. SERINE HYDROXYMETHYLTRANSFERASE WAS ASSAYED. NO CHANGES IN SPECIFIC ACTIVITY OR CELLULAR MORPHOLOGY NOTED @ CONCN LESS THAN 16 UMOL. CONCN OF 20 AND 40 UMOL LED TO LOWER GLIOMAL ENZYME SPECIFIC ACTIVITIES.THE GROWTH OF RABBIT HAIR WAS STIMULATED BY L-SERINE.SERINE INCREASED ETHANOL CONSUMPTION IN ISOLATED HEPATOCYTES FROM 18-HR STARVED AND FED RATS.