| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 94.4% (340 of 360) of all reports.Not ClassifiedAggregated GHS information provided per 360 reports by companies from 4 notifications to the ECHA C&L Inventory. |
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| Regulatorische Informationen | Chemical: L-Aspartic acidRegulation (EC) No 1831/2003 (amended)L-Aspartic acid is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of L-Aspartic acid are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 26-04-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/14876L-Aspartic acid: Does not have an individual approval but may be used under an appropriate group standardAspartic acid: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right. |
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| Weitere Sicherheitsinformationen | IMAP assessments - L-Aspartic acid: Environment tier I assessment |
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| Brandgefahren | Combustible. Finely dispersed particles form explosive mixtures in air. |
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| Gefahrenübersicht | Causes no skin and mild eye irritation in rabbits (classified by the EC as not irritating)Not a skin sensitizer in guinea pigs[IUCLID] An eye and respiratory tract irritant[ICSC] Safe when used as a flavoring agent in food[JECFA] An irritant that may cause severe eye irritation[Sigma-Aldrich MSDS] |
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| FDA-Anforderungen | L-Aspartic acid is a food additive permitted for direct addition to food for human consumption, as long as 1) the quantity of the substance added to food does not exceed the amount reasonably required to accomplish its intended physical, nutritive, or other technical effect in food, and 2) any substance intended for use in or on food is of appropriate food grade and is prepared and handled as a food ingredient. |
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| Chemical Dangers | Decomposes on burning. This produces toxic gases including nitrogen oxides. Reacts violently with oxidants. |
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| Physical Dangers | Dust explosion possible if in powder or granular form, mixed with air. If dry, it can be charged electrostatically by swirling, pneumatic transport, pouring, etc. |
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| Hazard Classes and Categories | Not Classified |
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| Brandbekämpfung | In case of fire in the surroundings, use appropriate extinguishing media. |
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| Erste-Hilfe-Maßnahmen | Fresh air, rest. Refer for medical attention.Remove contaminated clothes. Rinse and then wash skin with water and soap.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. |
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| Sichere Lagerung | Separated from strong oxidants. |
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| Entsorgungsverfahren | SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices. |
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| Verschüttetes entsorgen | Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water. Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. |
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| Eye Prevention | Wear safety spectacles. |
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| Fire Prevention | NO open flames. Prevent build-up of electrostatic charges (e.g., by grounding). Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust. |
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| Inhalation Risk | Evaporation at 20 °C is negligiblea nuisance-causing concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered. |
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| Skin Prevention | Protective gloves. |
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| Exposure Prevention | PREVENT DISPERSION OF DUST! |
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| Ingestion Prevention | Do not eat, drink, or smoke during work. |
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| Inhalation Prevention | Use local exhaust or breathing protection. |
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| Wechselwirkungen | ASPARTIC ACID PREVENTED TO SOME EXTENT THE APPEARANCE OF SYMPTOMS OF PHYSICAL MORPHINE DEPENDENCE IN BALB/C MICE.The effects of amino acids on the embryotoxicity and placental transfer of nickel chloride, day 10 rat embryos were cultured in rat serum medium containing nickel chloride or NiCl2-63 (0.34 or 0.68 uM NiCl with or without L-histidine (2 uM), L-aspartic acid, glycine (2 or 8 uM) or L-cysteine (2 uM). After 26 hr, conceptuses were assessed for survival, growth and development and malformations. The nickel-63 contents of embryos and yolk sacs and the extent of Nickel-63 binding to the proteins of the culture medium were also determined. Nickel chloride alone did not affect the embryonic development at 0.34 uM and caused growth retardation and brain and caudal abnormalities at 0.68 uM. Coincubation of L-histidine, L-cysteine, or L-aspartic acid 0.68 uM Ni reduced the growth retardation and the incidence and/or severity of brain defects caused by nickel chloride and decreased the concentrations of nickel-63 in the yolk sacs compared to 0.68 uM nickel-63 alone. In the presence of L-histidine, L-cysteine or L-aspartic acid there was a shift of nickel-63 binding from the high molecular weight proteins of the culture medium to the low molecular weight fraction.The effect of oral D-aspartic acid and/or L-aspartic acid (aspartic acid) on the body weight of rats was studied. Rats given the D- or D- plus L-isomers showed a greater decrease in weight and in protein, triglyceride and glycogen than did rats given the L-isomer alone. The results were discussed with reference to amino acid antagonism of opioids. |
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| Umweltverhalten | TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 39(SRC), determined from a water solubility of 5,360 mg/L at 25 °C(2) and a regression-derived equation(3), indicates that L-aspartic acid is expected to have very high mobility in soil(SRC). L-Aspartic acid has pKa values of 1.92, 3.87, and 9.87 at 25 °C(4) indicating that L-aspartic acid will exist as a zwitterion in the environment. Volatilization of L-aspartic acid from moist soil surfaces is not expected to be an important fate process(SRC) since ionic compounds do not volatilize. L-Aspartic acid is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 2.6X10-7 mm Hg at 25 °C(SRC), determined from a fragment constant method(5). Based on results from several screening tests, L-aspartic acid is expected to readily biodegrade under both aerobic (6-10) and anaerobic(11) conditions(SRC).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 39(SRC), determined from a water solubility of 5,360 mg/L at 25 °C(2) and a regression-derived equation(3), indicates that L-aspartic acid is not expected to adsorb to suspended solids and sediment(SRC). Measured pKa values of 1.92, 3.87, and 9.87 at 25 °C(4) indicate that L-aspartic acid will exist as a zwitterion in the environment. Volatilization from water surfaces is not expected because ionic compounds do not volatilize. According to a classification scheme(5), an estimated BCF of 0.7(SRC), from its water solubility(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC). The biodegradation of L-aspartic acid is expected to occur readily based on results from both screening and grab sample tests. Relative rates of total utilization of 2.7, 1.5, and 0.10%/hr were measured over a 4-hour period in three samples of seawater(6). In aerobic screening tests, 38.7 to 80.5% BODT was reached in 5 days using a sewage inoculum(7-9) while in an anaerobic screening test, 79% biodegradation was reported in 35 days(10).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), L-aspartic acid, which has an estimated vapor pressure of 2.6X10-7 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase L-aspartic acid is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 10 hours(SRC), calculated from its rate constant of 4.0x10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase L-aspartic acid may be removed from the air by wet or dry deposition(SRC). L-Aspartic acid does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight(4). |
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| Expositionspfade | The substance can be absorbed into the body by ingestion. |
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| Toxizitätsübersicht | Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org |
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| Signs and Symptoms | Cough. Sore throat.Redness. Pain.Burning sensation in the throat and chest. |
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| Soil Adsorption/Mobility | The Koc of L-aspartic acid is estimated as 39(SRC), using a water solubility of 5,360 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that L-aspartic acid is expected to have very high mobility in soil. However, L-aspartic acid has pKa values of 1.92, 3.87, and 9.87(5), indicating that this compound will exist as a zwitterion in the environment. In H(Al) montmorillonite, aspartic acid showed an L-2 type adsorption isotherm with an initial preferential sorption when compared with the solvent or other solutes followed by a decrease in sorption as more solute was sorbed(4). |
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| Natural Pollution Sources | Aspartic acid, as the DL mixture, is a naturally-occurring non-essential amino acid(1). |
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| Fish/Seafood Concentrations | Aspartic acid was measured in soft tissues of zebra mussels from Oneida Lake, NY collected in October and November of 1991 and clams (from previously published data, source not reported) at concentrations of 7.51 and 6.77 g/100 g dry weight, respectively(1). |
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| Artificial Pollution Sources | L-Aspartic acid's production and use as a roborant (1), a raw material in the synthesis of peptide drugs(2), and, as the DL-aspartic acid mixture, used in biological and clinical studies, preparation of culture media, an organic intermediate, an ingredient of aspartame, detergents, fungicides, germicides, and in metal complexation(3) may result in its release to the environment through various waste streams(SRC). |
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| Environmental Biodegradation | AEROBIC: The biodegradation of L-aspartic acid was measured in several BOD5 tests. After 5 days, 48.5%(1) 38.7(2) and 80.5%(3) of the theoretical BOD was reached using a sewage inoculum. L-Aspartic acid was degraded by 81% BODT after 30 days using a sewage inoculum(4). In a second Warburg test using an activated sludge inoculum, 8.9, 16.2, and 28.8% BODT was reached after 0.25, 0.5, and 1 day, respectively(5). DL-Aspartic acid was rapidly degraded by 98 to >99% in a laboratory-scale activated sludge unit at initial concentrations of 599, 1198, 2396, and 4792 mg/L and average detention times of 20.5, 29, 42, and 85 hours, respectively(6). Samples of marine water from the Scheldt estuary, the Belgian coastal zone of the North Sea, and the English Channel were incubated with 14C-labeled DL-aspartic acid and relative rates of total utilization (incorporation plus respiration) of 2.7, 1.5, and 0.10%/hr, respectively, were measured over a 4-hour period(7). Based on these data, L-aspartic acid is expected to biodegrade rapidly.ANAEROBIC: The biodegradability of L-aspartic acid at 2 g/L was measured in the Biochemical Methane Potential assay and incubated anaerobically at 35 and 55 °C. After 35 and 78 days, 79 and 73% bioconversion to methane was reported(1). The fermentation of L-aspartic acid proceeded through acetate and propionate(1). |
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| Sediment/Soil Concentrations | SOIL: Aspartic acid was not detectable in soil samples collected from 3 depths at a landfill in Spain containing urban wastes (detection limit not provided although measurements for other amino acids were provided in units of nmol/g)(1).SEDIMENT: A Fanning Island (Central Pacific Ocean)lagoon carbonate mud sediment contained aspartic acid at concentrations of 10.68, 8.40, 4.14, 3.10, 2.60, 4.11 and 3.38 umol/g in grain size fractions of <2, 2-6, 6-10, 10-20, 20-40, 63-125, 125-250 microns, respectively(1). |
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| Environmental Bioconcentration | An estimated BCF of 0.7 was calculated in fish for L-aspartic acid(SRC), using a water solubility of 5,360 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). |
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| Wassergefährdungsklasse (WGK) | 3 |
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| TSCA-Inventar-Status | TSCA listed |
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