Methyl-4-acetamido-2-ethoxybenzoat
METHYL 4-ACETAMIDO-2-ETHOXYBENZOATE · Methyl 4-(acetylamino)-2-ethoxybenzoate · 4-Acetamido-2-ethoxybenzoic acid, methyl ester · Ethopatate · ETHOPABATE · Ethytpatate · Ethyl pabate · Isovaleraldehvde
Identifikatoren & physikalische Daten
| CAS No. | 59-06-3 |
|---|---|
| Summenformel | C12H15NO4 |
| Durchschnittliche Molmasse | 237,25 g/mol |
| Monoisotopische Masse | 237,10010796 g/mol |
| SMILES | CCOc1cc(NC(C)=O)ccc1C(=O)OC |
| InChIKey | GOVWOKSKFSBNGD-UHFFFAOYSA-N |
| PubChem CID | 6034 |
| ChEMBL | CHEMBL458769 |
| ChEBI | CHEBI:183844 |
| EC No. | 200-414-3 |
| DTXSID | DTXSID6046264 |
| Lokaler Name | Methyl-4-acetamido-2-ethoxybenzoat |
Chemische & physikalische Eigenschaften
| XLogP | 1,2 |
|---|---|
| Polarare Oberfläche (TPSA) | 64,6 |
| H-Brücken-Donoren | 1 |
| H-Brücken-Akzeptoren | 4 |
| Frei drehbare Bindungen | 5 |
| Schwere Atome | 17 |
| Formalladung | 0 |
| Komplexität | 280 |
| Animal Drugs | Active Ingredients (Ethopabate) -> FDA GreenbookPharmaceuticals -> Animal Drugs -> Approved in Taiwan |
| Schmelzpunkt | 148-151 °C |
| Siedepunkt | 426.1±35.0 °C(Predicted) |
| Dichte | 1.180±0.06 g/cm3(Predicted) |
| Lagerbedingungen | Sealed in dry,Room Temperature |
| Löslichkeit | DMSO: 50 mg/mL (210.75 mM) |
| Aggregatzustand | A solid |
| pKa (Säurekonstante) | 14.12±0.70(Predicted) |
| Farbe | White to off-white |
| Merck | 13,3781 |
| Hauptanwendungen | forensics and toxicologypharmaceutical (small molecule) |
| InChI | InChI=1S/C12H15NO4/c1-4-17-11-7-9(13-8(2)14)5-6-10(11)12(15)16-3/h5-7H,4H2,1-3H3,(H,13,14) |
| InChIKey | GOVWOKSKFSBNGD-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)C1=CC=C(NC(C)=O)C=C1OCC |
| CAS Datenbank | 59-06-3(CAS DataBase Reference) |
| EPA chemische Informationen | Ethopabate (59-06-3) |
Sicherheit & Vorschriften
| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 2.1% (1 of 48) of reports.WarningH302 (95.8%): Harmful if swallowed [Warning Acute toxicity, oral]P264, P264+P265, P270, P280, P301+P317, P305+P351+P338, P330, P337+P317, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 48 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Regulatorische Informationen | Chemical: Benzoic acid, 4-(acetylamino)-2-ethoxy-, methyl ester |
| Hazard Classes and Categories | Acute Tox. 4 (95.8%) |
| Wassergefährdungsklasse (WGK) | 3 |
| Zollcode | 2924296000 |
| R-Sätze (R) | 22 |
| Gefahrensymbole | Xn |
| Lagerklasse | 11 - Combustible Solids |
| Gefahrenklasse | Acute Tox. 4 OralEye Irrit. 2 |
Anwendungen & Verwendung
Beschreibung
Ethopabate is a veterinary drug belonging to the class of antibiotics which contains an arylamide with a phenyl ring, a monocyclic aromatic hydrocarbon, and is a very safe drug used for the prophylaxis and treatment of coccidiosis in chickens. It has anticoccidial activity, especially against the intestinal form, and lacks activity against E. tenella of the cecum worm. The drug is a competitor of PABA, which is absorbed by the parasite and interferes with folate synthesis. It has good activity against E. acervulina and some strains of E. maxima and E. brunette. It is used only in combination with amprolium, first at a concentration of 4 ppm and later at a concentration of 40 ppm.This drug reaches peak activity on day 4 of the cycle.
Verwenden
A supplementary drug that improves the coccidiostatic effect of nicarbazin and amprolium in order to cure coccidiosis in chickens.