2-Hydroxyquinoline
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Grundinformationen
- CAS
104534-80-7- Standard-SMILES
O=c1ccc2ccccc2[nH]1- InChIKey
LISFMEBWQUVKPJ-UHFFFAOYSA-N- Summenformel
- C9H7NO
- Durchschnittliche Molmasse
- 145,16 g/mol
- Monoisotopische Masse
- 145,05276384
Überblick
Quinolin-2-ol is a monohydroxyquinoline carrying a hydroxy substituent at position 2. It is an intermediate metabolite produced duting the microbial degradation of quinoline. It has a role as a bacterial xenobiotic metabolite. It is a tautomer of a quinolin-2(1H)-one.
Namen und Bezeichner
- Bevorzugter Name
- 2-Hydroxyquinoline
- IUPAC
- 1H-quinolin-2-one
- Englischer Name
- 2-Hydroxyquinoline
- Summenformel
- C9H7NO
- Molmasse
- 145.15798
Namen und Synonyme
2-Hydroxyquinoline59-31-4CarbostyrilQuinolin-2(1H)-one2(1H)-Quinolinone2-Quinolone1H-quinolin-2-oneo-Aminocinnamic acid lactamalpha-Quinolone2-Quinolinone2(1H)-Quinolone803BHY7QWU
Weitere Namen anzeigen
DTXSID1058769NSC-156783CHEBI:18289RefChem:389257DTXCID7042510200-420-62-QuinolinolQuinolin-2-ol
Datenbank-Bezeichner
- CAS
104534-80-7、1321-40-0、59-31-4、70254-42-1- PubChem CID
- 6038
- DTXSID
DTXSID1058769- ChEMBL
CHEMBL186422- ChEBI
CHEBI:16365- UNII
- 803BHY7QWU
- EC Number
- 200-420-6、274-516-1
- Nikkaji
- J4.598E
Eigenschaften
Berechnete StruktureigenschaftenWird ergänzt
- XLogP
- 1,3
- Polarare Oberfläche (TPSA)
- 29,1 Ų
- H-Brücken-Donoren
- 1
- H-Brücken-Akzeptoren
- 1
- Frei drehbare Bindungen
- 0
- Schwere Atome
- 11
- Formalladung
- 0
- Komplexität
- 198
Experimentelle und physikochemische Eigenschaften
Chemical ClassesNitrogen Compounds -> Quinolines
DrugsPharmaceuticals -> Listed in ZINC15
LogP1.32
Physical DescriptionLight yellow crystalline solid; [Sigma-Aldrich MSDS]
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Danger
H302 (92%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 75 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Warning
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
Gefahrenhinweise
Regulatory Information
Chemical: 2-Quinolinol
2(1H)-Quinolinone: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - 2-Quinolinol: Human health tier I assessment
Hazards SummaryAn irritant; [Sigma-Aldrich MSDS] See Quinoline.
Hazard Classes and Categories
Skin Irrit. 2 (100%)
Acute Tox. 4 (92%)
Toxikologische Informationen
Adverse Effects
The most common reported adverse effects of quinolones include gastrointestinal events such as nausea, vomiting, and diarrhea. Antibiotic-associated colitis is a common sequela of quinolone use due to its effect on the gut flora. The use of quinolones may result in higher rates of clostridium difficile infection compared to other antibiotics. Arthralgias are also a common adverse effect, especially in the pediatric population, and self-resolve after discontinuing therapy. Some patients may also experience serious anaphylactic and skin reactions, ranging from a minor rash and/or photosensitivity to Stevens-Johnson syndrome or toxic epidermal necrolysis.
Chemie und Industrie
Verwendung und Herstellung
General Manufacturing Information2(1H)-Quinolinone: INACTIVE
Zugehörige Reaktionen
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