51-63-8CC(N)Cc1ccccc1.CC(N)Cc1ccccc1.O=S(=O)(O)OPYHRZPFZZDCOPH-UHFFFAOYSA-NAmphetamine sulfate is a white crystalline powder. Solution in water has a pH of 5-6. Odorless. Slightly bitter taste followed by a sensation of numbness. May be sensitive to light.
51-63-8、60-13-9DTXSID4020082CHEMBL501CHEBI:51063FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
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Danger
H300 (97.9%): Fatal if swallowed [Danger Acute toxicity, oral]
P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 48 reports by companies from 5 notifications to the ECHA C&L Inventory.
Danger
H301 (97.6%): Toxic if swallowed [Danger Acute toxicity, oral]
SYMPTOMS: Exposure to this compound may cause vasoconstriction, inhibition of motility of the gastrointestinal tract and bladder, dilation of the pupils, increased motor activity and mental alertness, euphoria, diminished sense of fatigue, increased wakefulness, insomnia, headache, hyperexcitability, and cardiac and gastrointestinal disturbances. Large doses may be followed by fatigue and mental depression, rise in blood pressure and mental concentration effects. Excessive use may lead to tolerance and physical dependence.
AMPHETAMINE SULFATE
Central Nervous System Stimulant [EPC]; Central Nervous System Stimulation [PE]
AMPHETAMINE SULFATE TABLETS
Central Nervous System Stimulant [EPC]; Central Nervous System Stimulation [PE]
A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here.
Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
Any drugs that are used for their effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.
Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters.
Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.
Drugs that block the transport of DOPAMINE into axon terminals or into storage vesicles within terminals. Most of the ADRENERGIC UPTAKE INHIBITORS also inhibit dopamine uptake.
Keine Reaktionsaufzeichnungen unter den aktuellen Filterkriterien.
Wird geladen…
Acute Tox. 2 (97.9%)
Acute Tox. 3 (97.6%)
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)
dl-Amphetamine Sulfate
TR-387: Toxicology and Carcinogenesis Studies of dl-Amphetamine Sulfate (CASRN 60-13-9) in F344/N Rats and B6C3F1 Mice (Feed Studies) (1991 )
04/25/90
No Evidence
No Evidence
No Evidence
Drug Induced Liver Injury Rank (DILIrank 2.0)
Amphetamine sulfate
vLess-DILI-concern
0
No match
DOI:10.1016/j.drudis.2016.02.015
Amphetamine sulfate
0.1
0.5
Usual dose is 5 to 60 milligrams per day in divided doses depending on the individual patient response.
Data used to generate the benchmarks include the following: Lowest Daily Dose (LDD): 5 mg/day, Lowest Therapeutic Dose (LTD): 0.1 mg/kg-day, and Screening Dose: 0.00002 mg/kg-day.
27-Dec-21