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Amphetamine Sulfate

HCID 6055
NotizenReaktionen
GrundinformationenÜberblickNamen und BezeichnerEigenschaftenSicherheit und RegulatorischesChemie und IndustrieZugehörige ReaktionenNotizen zur Verbindung
TeilstruktursucheÄhnliche Strukturen suchen

Grundinformationen

CAS
51-63-8
Standard-SMILES
CC(N)Cc1ccccc1.CC(N)Cc1ccccc1.O=S(=O)(O)O
InChIKey
PYHRZPFZZDCOPH-UHFFFAOYSA-N
Summenformel
C18H28N2O4S
Durchschnittliche Molmasse
368,5 g/mol
Monoisotopische Masse
368,17697855

Überblick

Amphetamine sulfate is a white crystalline powder. Solution in water has a pH of 5-6. Odorless. Slightly bitter taste followed by a sensation of numbness. May be sensitive to light.

Namen und Bezeichner

Bevorzugter Name
Amphetamine Sulfate
IUPAC
bis(1-phenylpropan-2-amine);sulfuric acid

Namen und Synonyme

DL-Amphetamine sulfateAmphetamine sulphatePhenaminumAstedinAmphamine sulfateAmphetamini sulfasBenzpropamineAdiparthrolEuphodineFenedrinIbiozedrinePsychoton
Weitere Namen anzeigen
SimpaminaAlentolBenniedl-Phenamine sulfatePhenamine sulfatedl-Amphetamine sulphateAmphetaminium sulfuricumBenzedrine sulfate

Datenbank-Bezeichner

CAS
51-63-8、60-13-9
PubChem CID
6055
DTXSID
DTXSID4020082
ChEMBL
CHEMBL501
ChEBI
CHEBI:51063
UNII
6DPV8NK46S
EC Number
200-457-8

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA)
135 Ų
H-Brücken-Donoren
4
H-Brücken-Akzeptoren
6
Frei drehbare Bindungen
4
Schwere Atome
25
Formalladung
0
Komplexität
166

Experimentelle und physikochemische Eigenschaften

Density1.15 at 77 °F (NTP, 1992) - Denser than water; will sink
Solubility50 to 100 mg/mL at 61 °F (NTP, 1992)
Human Drugs · 2 Einträge

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

Melting Point536 to 538 °F (NTP, 1992)
Physical DescriptionAmphetamine sulfate is a white crystalline powder. Solution in water has a pH of 5-6. Odorless. Slightly bitter taste followed by a sensation of numbness. May be sensitive to light.

Sicherheit und Regulatorisches

Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.

GHS-Klassifizierung

GHS Classification · 6 Einträge

Danger

H300 (97.9%): Fatal if swallowed [Danger Acute toxicity, oral]

P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 48 reports by companies from 5 notifications to the ECHA C&L Inventory.

Danger

H301 (97.6%): Toxic if swallowed [Danger Acute toxicity, oral]

Gefahrenhinweise

Regulatory InformationDextroamphetamine sulphate: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - Benzeneethanamine, .alpha.-methyl-, (S)-, sulfate (2:1): Environment tier I assessment
DOT LabelPoison
Fire HazardsFlash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)
Health Hazards · 1 Eintrag

SYMPTOMS: Exposure to this compound may cause vasoconstriction, inhibition of motility of the gastrointestinal tract and bladder, dilation of the pupils, increased motor activity and mental alertness, euphoria, diminished sense of fatigue, increased wakefulness, insomnia, headache, hyperexcitability, and cardiac and gastrointestinal disturbances. Large doses may be followed by fatigue and mental depression, rise in blood pressure and mental concentration effects. Excessive use may lead to tolerance and physical dependence.

Reactive GroupHydrocarbons, Aromatic
Reactivity Profile

Chemie und Industrie

Pharmakologische Informationen

FDA Pharmacological Classification · 4 Einträge

AMPHETAMINE SULFATE

Central Nervous System Stimulant [EPC]; Central Nervous System Stimulation [PE]

AMPHETAMINE SULFATE TABLETS

Central Nervous System Stimulant [EPC]; Central Nervous System Stimulation [PE]

MeSH Pharmacological Classification · 6 Einträge

A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here.

Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.

Any drugs that are used for their effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.

Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters.

Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.

Drugs that block the transport of DOPAMINE into axon terminals or into storage vesicles within terminals. Most of the ADRENERGIC UPTAKE INHIBITORS also inhibit dopamine uptake.

Zugehörige Reaktionen

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Notizen zur Verbindung

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Auf dieser SeiteGrundinformationenÜberblickNamen und BezeichnerEigenschaftenSicherheit und RegulatorischesChemie und IndustrieZugehörige ReaktionenNotizen zur Verbindung
Incompatible with alkalis and calcium salts. (NTP, 1992). A weak acid.
Air and Water ReactionsWater soluble. Hygroscopic.
Hazard Classes and Categories · 2 Einträge

Acute Tox. 2 (97.9%)

Acute Tox. 3 (97.6%)

Sicherheit und Schutzausrüstung

Fire FightingFires involving this compound should be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
First Aid · 1 Eintrag

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Nonfire Spill Response · 1 Eintrag

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Isolation and EvacuationExcerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:
Personal Protective Equipment (PPE) · 1 Eintrag

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)

Toxikologische Informationen

Carcinogen Classification · 6 Einträge

dl-Amphetamine Sulfate

TR-387: Toxicology and Carcinogenesis Studies of dl-Amphetamine Sulfate (CASRN 60-13-9) in F344/N Rats and B6C3F1 Mice (Feed Studies) (1991 )

04/25/90

No Evidence

No Evidence

No Evidence

Drug Induced Liver Injury · 6 Einträge

Drug Induced Liver Injury Rank (DILIrank 2.0)

Amphetamine sulfate

vLess-DILI-concern

0

No match

DOI:10.1016/j.drudis.2016.02.015

EPA Human Health Benchmarks for Pharmaceuticals · 6 Einträge

Amphetamine sulfate

0.1

0.5

Usual dose is 5 to 60 milligrams per day in divided doses depending on the individual patient response.

Data used to generate the benchmarks include the following: Lowest Daily Dose (LDD): 5 mg/day, Lowest Therapeutic Dose (LTD): 0.1 mg/kg-day, and Screening Dose: 0.00002 mg/kg-day.

27-Dec-21