Grundinformationen
- CAS
60-31-1- Standard-SMILES
CC(=O)OCC[N+](C)(C)C.[Cl-]- InChIKey
JUGOREOARAHOCO-UHFFFAOYSA-M- Summenformel
- C7H16ClNO2
- Durchschnittliche Molmasse
- 181,66 g/mol
- Monoisotopische Masse
- 181,0869564
Überblick
Acetylcholine chloride is the chloride salt of acetylcholine, and a parasympatomimetic drug. It contains an acetylcholine.
Namen und Bezeichner
- Bevorzugter Name
- Acetylcholine Chloride
- IUPAC
- 2-acetyloxyethyl(trimethyl)azanium chloride
- Lokaler Name
- Acetylcholinchlorid
- Englischer Name
- Acetylcholine chloride
- Summenformel
- C7H16ClNO2
- Molmasse
- 181.66
Namen und Synonyme
ACETYLCHOLINE CHLORIDE60-31-1MiocholChloroacetylcholineOvisotACH chloride2-Acetoxyethyltrimethylammonium chlorideCholine acetate (ester) chlorideMIOCHOL-ECloruro de acetilcolinaChlorure d'acetylcholineEthanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, chloride
Weitere Namen anzeigen
ACHtl1505acecholinACECOLINEachchloridearterocolineARTEROCHOLINEAcetylcholine Cl
Acetilcolina cloruro(2-Hydroxyethyl)trimethylammonium chloride acetateAcetylcholini chloridumDTXSID5048978NSC-755845AF73293C2Racetylcholine chloride for injection2-acetyloxy-N,N,N-trimethylethanaminium chloride
Datenbank-Bezeichner
- CAS
60-31-1- PubChem CID
- 6060
- DTXSID
DTXSID5048978
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 26,3 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 3
- Frei drehbare Bindungen
- 4
- Schwere Atome
- 11
- Formalladung
- 0
- Komplexität
- 115
Experimentelle und physikochemische Eigenschaften
Solubility>27.2 [ug/mL] (The mean of the results at pH 7.4)
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Physikochemische Eigenschaften
- Schmelzpunkt
- 146 · 146-150 °C (lit.)
- Dichte
- 1.1235 · 1.1235 (rough estimate)
- Brechungsindex
- 1.556 · 1.5560 (estimate)
- storage temp.
- room temp
- Löslichkeit
- 2 O: · H2O: 0.1 g/mL, clear, colorless
- Aggregatzustand
- Crystalline Powder
- Farbe
- White
- Biologische Quelle
- synthetic
- Wasserlöslichkeit
- Soluble IN COLD WATER
- Merck
- 14 · 14,87
- BRN
- 3571875 · 3571875
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 161 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Regulatory InformationEthanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, chloride: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, chloride: Environment tier I assessment
Hazard Classes and CategoriesSkin Irrit. 2 (100%)
Toxikologische Informationen
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Acetylcholine chloride
vNo-DILI-concern
0
No match
DOI:10.1016/j.drudis.2016.02.015
Sicherheitsdaten
- F
- 3-8-10-21
- wgk
- 2
- tsca
- TSCA listed
- hs_code
Chemie und Industrie
Pharmakologische Informationen
FDA Pharmacological Classification
ACETYLCHOLINE CHLORIDE
Cholinergic Agonists [MoA]; Cholinergic Receptor Agonist [EPC]
ACETYLCHOLINE CHLORIDE,
Cholinergic Agonists [MoA]; Cholinergic Receptor Agonist [EPC]
MeSH Pharmacological Classification
Drugs used to cause dilation of the blood vessels.
Drugs that bind to and activate cholinergic receptors.
Verwendung und Herstellung
General Manufacturing InformationEthanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, chloride (1:1): ACTIVE
Anwendungen
BeschreibungAcetylcholine is a neurotransmitter that binds to nicotinic and muscarinic acetylcholine receptors (AChRs) in the central and peripheral nervous systems. It mediates motor function at the neuromuscular junction but also has functions in the parasympathetic and sympathetic nervous systems. It is involved in learning and memory through actions at nicotinic AChRs in the CNS. The actions of acetylcholine are terminated primarily via the action of acetylcholinesterase, which breaks it down into acetate and choline. Acetylcholine (chloride) mimics the effects of acetylcholine and has been used to determine the function of acetylcholine in various biological processes. Acetylcholine (chloride) inhibits peptide aggregation of p53 mutants in vitro at micromolar concentrations. It increases alveolar fluid clearance in a dose-dependent manner and enhances Na+/K+-ATPase activity, effects which are blocked by atropine , in a mouse model of pulmonary edema.
VerwendenAcetylcholine Chloride is a cholinergic, antiarrhythmic, miotic, vasodilator (peripheral).
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