Grundinformationen
- Standard-SMILES
O=C1Nc2ccccc2C1O- InChIKey
SGZFJWQQBHYNNF-UHFFFAOYSA-N- Summenformel
- C8H7NO2
- Durchschnittliche Molmasse
- 149,15 g/mol
- Monoisotopische Masse
- 149,04767847
Namen und Bezeichner
- Bevorzugter Name
- Dioxindole
- IUPAC
- 3-hydroxy-1,3-dihydroindol-2-one
- Englischer Name
- 3-Iodophenyl acetate
- Summenformel
- C8H7NO2
- Molmasse
- 149.15
Namen und Synonyme
3-hydroxyindolin-2-oneDioxindole61-71-23-Hydroxy-2-oxoindole1,3-Dihydro-3-hydroxy-2H-indol-2-one3-hydroxy-1,3-dihydro-2H-indol-2-oneCHEBI:28536DTXSID801018937RefChem:502559DTXCID9014769503-hydroxyoxindole3-hydroxy-2,3-dihydro-1H-indol-2-one
Weitere Namen anzeigen
dioxindolo-Aminomandelic lactam3-Hydroxyindoline-2-one3-Hydroxy-1H-indole-2(3H)-one2,3-Dihydro-3-hydroxy-1H-indole-2-one
3-hydroxy-1,3-dihydroindol-2-one3-hydroxy-2-indolinoneCHEMBL21527172H-INDOL-2-ONE, 1,3-DIHYDRO-3-HYDROXY-NSC-263192-Indolinone, 3-hydroxy-Oxindole, 3-hydroxy-NSC 26319
Datenbank-Bezeichner
- CAS
61-71-2- PubChem CID
- 6097
- DTXSID
DTXSID801018937- ChEMBL
CHEMBL2152717- ChEBI
CHEBI:28536- UNII
- NSL4M8FFA2
- EC Number
- 826-730-7
- Nikkaji
- J4.817H
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 0,2
- Polarare Oberfläche (TPSA)
- 49,3 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 2
- Frei drehbare Bindungen
- 0
- Schwere Atome
- 11
- Formalladung
- 0
- Komplexität
- 181
Physikochemische Eigenschaften
- Schmelzpunkt
- 167 · 167-168 °C
- Siedepunkt
- 368.2 · 368.2±42.0 °C(Predicted)
- Dichte
- 1.38 · 1.380±0.06 g/cm3(Predicted)
- pka
- 12.35 · 12.35±0.20(Predicted)
Sicherheit und Regulatorisches
GHS-Klassifizierung
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]；H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Gefahrenhinweise
Hazard Classes and CategoriesAcute Tox. 4 (100%)；Skin Irrit. 2 (100%)；Eye Irrit. 2A (100%)；STOT SE 3 (100%)
Sicherheitsdaten
- Alarmwort
- Warnung
- Gefahrenhinweise
- Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H302
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.
A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414)
Anbieter4 Anbieter
砌块化学科技（上海）有限公司021-20432219 13918097649 · [email protected]
江苏艾康生物医药研发有限公司025-58851090 13913916777 · [email protected]
南京合巨药业有限公司025-57027686 17372956142 · [email protected]
北京新研汇医药研发有限公司13969155946 · [email protected]
Ergänzende Hinweise
DefinitionChEBI: An oxindole that is 1,3-dihydro-2H-indol-2-one substituted by a hydroxy group at position 3.
Zugehörige Reaktionen
6
Verknüpfte Notizen
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