HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Aminoethyldiethylamin
DEEDA · DEAEA · N,N-DIETHYL-1,2-ETHANEDIAMINE · diethylethylenediamine · usafam-1 · USAF am-1 · RARECHEM AL BW 0199 · 2-Aminotriethylamine
Identifikatoren & physikalische Daten
| CAS No. | 100-36-7 |
|---|---|
| Summenformel | C6H16N2 |
| Durchschnittliche Molmasse | 116,2 g/mol |
| Monoisotopische Masse | 116,13134852 g/mol |
| SMILES | CCN(CC)CCN |
| InChIKey | UDGSVBYJWHOHNN-UHFFFAOYSA-N |
| PubChem CID | 60993 |
| ChEMBL | CHEMBL52701 |
| EC No. | 202-844-7 |
| DTXSID | DTXSID7057606 |
| Lokaler Name | 2-Aminoethyldiethylamin |
Chemische & physikalische Eigenschaften
| XLogP | 0,2 |
|---|---|
| Polarare Oberfläche (TPSA) | 29,3 |
| H-Brücken-Donoren | 1 |
| H-Brücken-Akzeptoren | 2 |
| Frei drehbare Bindungen | 4 |
| Schwere Atome | 8 |
| Formalladung | 0 |
| Komplexität | 41 |
| Dampfdruck | 2.97 [mmHg]5.33hPa at 20℃ |
| Physical Description | LiquidColorless liquid[Alfa Aesar MSDS] |
| Schmelzpunkt | <-70°C |
| Siedepunkt | 145-147 °C(lit.) |
| Dichte | 0.827 g/mL at 25 °C(lit.) |
| Brechungsindex | n20/D 1.436(lit.) |
| Flammpunkt | 87 °F |
| Lagerbedingungen | Store below +30°C. |
| Löslichkeit | soluble in Methanol, WaterMISCIBLE |
| Aggregatzustand | Liquid |
| pKa (Säurekonstante) | pK1:7.70(+2)pK2:10.46(+1) (25°C) |
| Farbe | Clear colorless to light yellow |
| Explosionsgrenze | 0.7-8.4%(V) |
| BRN | 605299 |
| InChI | 1S/C6H16N2/c1-3-8(4-2)6-5-7/h3-7H2,1-2H3 |
| InChIKey | PQZTVWVYCLIIJY-UHFFFAOYSA-N |
| SMILES | CCN(CC)CCN |
| LogP (Verteilungskoeffizient) | 0.1 at 25℃ |
| CAS Datenbank | 100-36-7(CAS DataBase Reference) |
| NIST chemische Informationen | 1,2-Ethanediamine, N,N-diethyl-(100-36-7) |
| EPA chemische Informationen | N,N-Diethylethylenediamine (100-36-7) |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH226 (98.8%): Flammable liquid and vapor [Warning Flammable liquids]H302 (69.6%): Harmful if swallowed [Warning Acute toxicity, oral]H311 (96.3%): Toxic in contact with skin [Danger Acute toxicity, dermal]H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]H318 (70.2%): Causes serious eye damage [Danger Serious eye damage/eye irritation]H332 (26.1%): Harmful if inhaled [Warning Acute toxicity, inhalation]P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P330, P361+P364, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 161 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
|---|---|
| Regulatorische Informationen | Chemical: 1,2-Ethanediamine, N,N-diethyl-1,2-Ethanediamine, N1,N1-diethyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2-Ethanediamine, N1,N1-diethyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 18-10-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/117132-Aminoethyldiethylamine: Does not have an individual approval but may be used under an appropriate group standard |
| Brandgefahren | · Flammable/combustible material.· May be ignited by heat, sparks or flames.· Vapors may form explosive mixtures with air.· Vapors may travel to source of ignition and flash back.· Most vapors are heavier than air. They will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.).· Vapor explosion hazard indoors, outdoors or in sewers.· Those substances designated with a (P) may polymerize explosively when heated or involved in a fire.· Runoff to sewer may create fire or explosion hazard.· Containers may explode when heated.· Many liquids will float on water. |
| Gesundheitsgefahren | · May cause toxic effects if inhaled or ingested.· Contact with substance may cause severe burns to skin and eyes.· Fire will produce irritating, corrosive and/or toxic gases.· Vapors may cause dizziness or asphyxiation, especially when in closed or confined areas.· Runoff from fire control or dilution water may cause environmental contamination. |
| Gefahrenübersicht | Causes burnsInhalation may cause corrosive injuries to upper respiratory tract and lungsHarmful by skin contact[Alfa Aesar MSDS] |
| DOT-Nummer und Handbuch | 2685 132 |
| DOT Hazard Classification | N,N-DiethylethylenediamineUN2685Class 8 Corrosive material (49 eCFR § 173.136)Class 3 Flammable and combustible liquid (49 eCFR § 173.120)PG II: the degree of danger presented by the material is mediumFor more information about the packing group assignment, please visit 49 eCFR § 173 |
| Hazard Classes and Categories | Flam. Liq. 3 (98.8%)Acute Tox. 4 (69.6%)Acute Tox. 3 (96.3%)Skin Corr. 1B (100%)Eye Dam. 1 (70.2%)Acute Tox. 4 (26.1%)Flammable liquids - Category 3Acute toxicity (Dermal) - Category 3Skin corrosion/irritation - Category 1Serious eye damage/eye irritation - Category 1 |
| Freisetungsmaßnahmen | · CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· Keep unauthorized personnel away.· Stay upwind, uphill and/or upstream.· Ventilate closed spaces before entering, but only if properly trained and equipped.· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.· All equipment used when handling the product must be grounded.· Do not touch or walk through spilled material.· Stop leak if you can do it without risk.· Prevent entry into waterways, sewers, basements or confined areas.· A vapor-suppressing foam may be used to reduce vapors.· Absorb with earth, sand or other non-combustible material.· For hydrazine, absorb with DRY sand or inert absorbent (vermiculite or absorbent pads).· Use clean, non-sparking tools to collect absorbed material.Large Spill· Dike far ahead of liquid spill for later disposal.· Water spray may reduce vapor, but may not prevent ignition in closed spaces. |
| Erste Hilfe | General First Aid:· Call 911 or emergency medical service.· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.· Move victim to fresh air if it can be done safely.· Administer oxygen if breathing is difficult.· If victim is not breathing:-- DO NOT perform mouth-to-mouth resuscitationthe victim may have ingested or inhaled the substance.-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.· Remove and isolate contaminated clothing and shoes.· For minor skin contact, avoid spreading material on unaffected skin.· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.· For severe burns, immediate medical attention is required.· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.· Keep victim calm and warm.· Keep victim under observation.· For further assistance, contact your local Poison Control Center.· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.Specific First Aid:· For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required. |
| Expositionsschutz und Persönliche Schutzausrüstung | · Wear positive pressure self-contained breathing apparatus (SCBA).· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection. |
| Isolation and Evacuation | Immediate precautionary measure· Isolate spill or leak area for at least 50 meters (150 feet) in all directions.· For highlighted materials: see Table 1 - Initial Isolation and Protective Action Distances.· For non-highlighted materials: increase the immediate precautionary measure distance, in the downwind direction, as necessary.Fire· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directionsalso, consider initial evacuation for 800 meters (1/2 mile) in all directions. |
| Emergency Response Planning Guidelines | · Some of these materials may react violently with water.Small Fire· Dry chemical, CO2, water spray or alcohol-resistant foam.Large Fire· Water spray, fog or alcohol-resistant foam.· If it can be done safely, move undamaged containers away from the area around the fire.· Dike runoff from fire control for later disposal.· Do not get water inside containers.Fire Involving Tanks, Rail Tank Cars or Highway Tanks· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.· Cool containers with flooding quantities of water until well after fire is out.· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.· ALWAYS stay away from tanks in direct contact with flames.· For massive fire, use unmanned master stream devices or monitor nozzlesif this is impossible, withdraw from area and let fire burn. |
| Unerwünschte Wirkungen | Dermatotoxin - Skin burns.Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors. |
| Wassergefährdungsklasse (WGK) | 1 |
| TSCA-Inventar-Status | TSCA listed |
| UN-Transportnummer | UN 2685 |
| Zollcode | 29212900 |
| RTECS-Nr. | KV3500000 |
| R-Sätze (R) | 10-20/21/22-35-21-36/37/38-34 |
| Toxizität | LD50 orally in Rabbit: 984 mg/kg LD50 dermal Rabbit 820 mg/kg |
| Gefahrensymbole | C,Xi |
| Sicherheitshinweise (S) | 26-36/37/39-45-25-16-36-27 |
| Gefahrenklasse | 8Acute Tox. 3 DermalAcute Tox. 4 InhalationFlam. Liq. 3Skin Corr. 1A |
| Verpackungsgruppe | II |
| Lagerklasse | 3 - Flammable liquids |
| Selbstentzündungstemperatur | 245 °C |
Anwendungen & Verwendung
Verwenden
N,N-Diethylethylenediamine is used in the syntheses of anti-malarials. In addition, it has been seem to induce apoptosis through a caspase-3 dependent pathway.