Natriumcalciumedetat
Calcium;disodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate
Grundinformationen
- CAS
62-33-9- Standard-SMILES
O=C([O-])CN(CCN(CC(=O)[O-])CC(=O)[O-])CC(=O)[O-].[Ca+2].[Na+].[Na+]- InChIKey
SHWNNYZBHZIQQV-UHFFFAOYSA-J- Summenformel
- C10H12CaN2Na2O8
- Durchschnittliche Molmasse
- 374,27 g/mol
- Monoisotopische Masse
- 374,0014948
Überblick
Edetate calcium disodium is a metal ion chelator used to reduce blood concentrations and depot stores of lead from the body. It is on the World Health Organization Model List of Essential Medicines. Edetate calcium disodium was granted FDA approval on 16 July 1953.
Namen und Bezeichner
- Bevorzugter Name
- Calcium;disodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate
- IUPAC
- calcium;disodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate
- Lokaler Name
- Natriumcalciumedetat
- Englischer Name
- EDTA calcium disodium
- Summenformel
- C10H12CaN2Na2O8.xH2O
- Molmasse
- 374.27
Namen und Synonyme
calcium;disodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetateEDTA, DISODIUM CALCIUM SALT TRIHYDRATED07934EDETATE CALCIUM DISODIUMCALCIUM DISODIUM EDETATEE385Calcium edetate sodiumedtacalmosatiltetacinantallinchelaton
Weitere Namen anzeigen
edetamin
Datenbank-Bezeichner
- CAS
62-33-9- PubChem CID
- 6109
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 167 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 10
- Frei drehbare Bindungen
- 2
- Schwere Atome
- 23
- Formalladung
- 0
- Komplexität
- 342
Experimentelle und physikochemische Eigenschaften
Melting Point>300
Physikochemische Eigenschaften
- Schmelzpunkt
- 300 °C · >300°C
- storage temp.
- room temp
- Löslichkeit
- Freely soluble in water, practically insoluble in ethanol (96 per cent).
- Aggregatzustand
- Liquid, solid
- Farbe
- Off white
- Geruch (Odor)
- Odorless
- Merck
- 14 · 14,3517
- Stabilität
- Stable. Incompatible with strong oxidizing agents.
- Major Application
- pharmaceutical (small molecule)
- Kosmetik-Inhaltsstoffe Funktionen
- CHELATING
- InChI
- InChI=1S/C10H16N2O8.Ca.2Na/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;/q;+2;2*+1/p-4
- InChIKey
- SHWNNYZBHZIQQV-UHFFFAOYSA-J
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- 2
- tsca
- TSCA listed
- hs_code
- 29349990
- RTECS-Nr.
- EV7700000
- risk_code
- 36/37/38
- hazard_code
- Xi
- safety_code
- 26-36
- Speicherklasse
- 11 - Combustible Solids
- Giftige Stoffe Daten
- 62-33-9(Hazardous Substances Data)
Chemie und Industrie
Pharmakologische Informationen
Pharmacodynamics
Edetate calcium disodium is a polyvalent ion chelator used to remove lead from the body after lead poisoning. It has a wide therapeutic index, as overdoses must be well in excess of the therapeutic dose to show symptoms. It has a long duration of action, as doses are given at least a day apart. Patients should be counselled regarding the risk of increased intracranial pressure with intravenous infusions.
Mechanism of Action
Edetate calcium disodium distributes into tissues, such as the kidney and bone, where it chelates lead ions. The lead ions are then eliminated in the normal urinary excretion of edetate. Lead in certain tissues such as the liver and bone, redistribute to other tissues after edetate calcium disodium treatment, but lead levels do not decrease to levels seen in unexposed patients.
Biological Half-LifeThe half life of edetate calcium disodium is 20-60 minutes.
Metabolism/MetabolitesEdetate calcium disodium is almost completely unmetabolized _in vivo_.
Absorption, Distribution and Excretion
Calcium edetate disodium's Cmax and AUC are dependant on renal function. 5% of an oral dose is absorbed from the gastrointestinal tract.
Edetate calcium disodium is 95% eliminated in the urine within 24 hours. An oral dose in rats was 88.32% recovered in the feces and 10.30% recovered in the urine.
The volume of distribution of edetate calcium disodium is 0.19±0.10L/kg.
The mean clearance of edetate in 1 month olds is 54.6mL/min/1.73m<sup>2</sup>. 2-17 year olds have a mean clearance of 113.9±24.4mL/min/1.73m<sup>2</sup>.
Anwendungen
VerwendenEDTA calcium disodium is a sequestrant and chelating agent whose complete name is disodium calcium ethylenediamine tetraacetate. It is a nonhygroscopic powder that is colorless, odorless, and tasteless at recommended use levels. A 1% solution has a ph of 6.5–7.5. It is used to control the reaction of trace metals with some organic and inorganic components in food; to prevent deterioration of color, texture, and development of precipitates; and to prevent oxidation. Its function is comparable to that of disodium dihydrogen edta. It is also termed calcium disodium edta.
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