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Uridin-5'-(tetrahydrogentriphosphat)
UTP TRISODIUM SALT · URIDINE-5'-TRIPHOSPHATE TRISODIUM SALT · UTP-NA · UTP Sodium · Uridine 5'-triphosphate · Uridine 5'-(tetrahydrogen triphosphate) · pppU · 5’-utp
Identifikatoren & physikalische Daten
| CAS No. | 63-39-8 |
|---|---|
| Summenformel | C9H15N2O15P3 |
| Durchschnittliche Molmasse | 484,14 g/mol |
| Monoisotopische Masse | 483,96852767 g/mol |
| SMILES | O=c1ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)c(=O)[nH]1 |
| InChIKey | PGAVKCOVUIYSFO-XVFCMESISA-N |
| PubChem CID | 6133 |
| ChEMBL | CHEMBL336296 |
| ChEBI | CHEBI:15713 |
| EC No. | 200-558-7 |
| DTXSID | DTXSID0041147 |
| Lokaler Name | Uridin-5'-(tetrahydrogentriphosphat) |
Chemische & physikalische Eigenschaften
| XLogP | -5,8 |
|---|---|
| Polarare Oberfläche (TPSA) | 259 |
| H-Brücken-Donoren | 7 |
| H-Brücken-Akzeptoren | 15 |
| Frei drehbare Bindungen | 8 |
| Schwere Atome | 29 |
| Formalladung | 0 |
| Komplexität | 839 |
| Stoffklassen | Biological Agents -> Nucleic Acids and Derivatives |
| Arzneimittel | Pharmaceuticals -> Listed in ZINC15 |
| Physical Description | Solid |
| Collision Cross Section | 187 Ų [M+H]+ [CCS Type: DTMethod: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]178.55 Ų [M-H]- [CCS Type: DTMethod: single field calibrated with Agilent tune mix (Agilent)]188.5 Ų [M+Na]+ |
| Dichte | 2.106±0.06 g/cm3(Predicted) |
| Flammpunkt | 113 °C |
| Lagerbedingungen | Sealed in dry,2-8°C |
| Löslichkeit | Easily soluble (water)Water : ≥ 150 mg/mL (309.83 mM) |
| pKa (Säurekonstante) | pK1:7.58 (25°C) |
| Aggregatzustand | liquid |
| Farbe | colorless |
| pH | 7.0 ± 0.1 |
| Biologische Quelle | yeast (Candida Utilis) |
| InChIKey | PGAVKCOVUIYSFO-XVFCMESISA-N |
| SMILES | C(OP(=O)(O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](O)[C@@H]1O |
| CAS Datenbank | 63-39-8(CAS DataBase Reference) |
| EPA chemische Informationen | Uridine 5'-(tetrahydrogen triphosphate) (63-39-8) |
Sicherheit & Vorschriften
| Regulatorische Informationen | Uridine triphosphate: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right. |
|---|---|
| Gefahrenübersicht | A skin and strong eye irritantHarmful by ingestion[Ark Pharm MSDS] |
| Wassergefährdungsklasse (WGK) | 1 |
| R-Sätze (R) | 20/21/22-68/20/21/22 |
| Gefahrensymbole | Xn |
| Sicherheitshinweise (S) | 22-26-36 |
Anwendungen & Verwendung
Beschreibung
Uridine triphosphate (UTP;Uridine 5'-triphosphate) is a nucleotide that regulates the functions of the pancreas in endocrine and exocrine secretion, proliferation, channels, transporters, and intracellular signaling under normal and disease states.
Verwenden
Uridine 5′-triphosphate trisodium salt solution has been used to increase the intracellular Ca2+ levels in rat primary tracheal epithelial cells. It has also been used as a nucleotide substrate to analyze the activity of MutT homologue 1 (MTH1).