Uridin-5'-(tetrahydrogentriphosphat)
Uridine 5'-triphosphate
Grundinformationen
- CAS
63-39-8- Standard-SMILES
O=c1ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)c(=O)[nH]1- InChIKey
PGAVKCOVUIYSFO-XVFCMESISA-N- Summenformel
- C9H15N2O15P3
- Durchschnittliche Molmasse
- 484,14 g/mol
- Monoisotopische Masse
- 483,96852877
Überblick
UTP is a pyrimidine ribonucleoside 5'-triphosphate having uracil as the nucleobase. It has a role as a mouse metabolite and an Escherichia coli metabolite. It is a uridine 5'-phosphate and a pyrimidine ribonucleoside 5'-triphosphate. It is a conjugate acid of an UTP(4-) and an UTP(3-).
Namen und Bezeichner
- Bevorzugter Name
- Uridine 5'-triphosphate
- IUPAC
- [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
- Lokaler Name
- Uridin-5'-(tetrahydrogentriphosphat)
- Englischer Name
- UTP
- Summenformel
- C9H15N2O15P3
- Molmasse
- 484.14
Namen und Synonyme
uridine 5'-triphosphateuridine triphosphate63-39-8UteplexMagnesium UTPUTP, MagnesiumTriphosphate, UridineMg UTPMagnesium Uridine TriphosphateTriphosphate, Magnesium UridineDTXSID0041147INS-316
Weitere Namen anzeigen
UTP TRISODIUM SALTURIDINE-5'-TRIPHOSPHATE TRISODIUM SALTUTP-NAUTP SodiumpppU5’-utpUTP, 3NA
UT0S826Z60[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate(((2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl)methoxy-hydroxyphosphoryl) phosphono hydrogen phosphateRefChem:901473DTXCID8021147(((((((2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)phosphonic acid200-558-7Uridine 5'-(tetrahydrogen triphosphate)
Datenbank-Bezeichner
- CAS
63-39-8
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- -5,8
- Polarare Oberfläche (TPSA)
- 259 Ų
- H-Brücken-Donoren
- 7
- H-Brücken-Akzeptoren
- 15
- Frei drehbare Bindungen
- 8
- Schwere Atome
- 29
- Formalladung
- 0
- Komplexität
- 839
Experimentelle und physikochemische Eigenschaften
Chemical ClassesBiological Agents -> Nucleic Acids and Derivatives
DrugsPharmaceuticals -> Listed in ZINC15
Physical DescriptionSolid
Collision Cross Section
180.1 Ų [M-H]- [CCS Type: DT; Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]
178.55 Ų [M-H]- [CCS Type: DT; Method: single field calibrated with Agilent tune mix (Agilent)]
186.9 Ų [M+H]+
Physikochemische Eigenschaften
- Dichte
- 2.106 · 2.106±0.06 g/cm3(Predicted)
- Flammpunkt
- 113 °C · 113 °C
- storage temp.
- 2 · Sealed in dry,2-8°C
- Löslichkeit
- Easily soluble (water)
- pka
- 1 · pK1:7.58 (25°C)
- Aggregatzustand
- liquid
- Farbe
- colorless
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Gefahrenhinweise
Regulatory InformationUridine triphosphate: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Hazards SummaryA skin and strong eye irritant; Harmful by ingestion; [Ark Pharm MSDS]
Sicherheitsdaten
- wgk
- 1
- risk_code
- 20/21/22-68/20/21/22
- hazard_code
- Xn
- safety_code
- 22-26-36
Chemie und Industrie
Pharmakologische Informationen
Cellular LocationsCytoplasm
Metabolite PathwaysAmikacin Action Pathway
Verwendung und Herstellung
Uses
Pyrimidine analog of adenosine triphosphate (ATP); Used to treat cystic fibrosis; [Merck Index]
Use (kg; approx.) in Germany (2009): >10
Anwendungen
BeschreibungUridine triphosphate (UTP;Uridine 5'-triphosphate) is a nucleotide that regulates the functions of the pancreas in endocrine and exocrine secretion, proliferation, channels, transporters, and intracellular signaling under normal and disease states.
VerwendenUridine 5′-triphosphate trisodium salt solution has been used to increase the intracellular Ca2+ levels in rat primary tracheal epithelial cells. It has also been used as a nucleotide substrate to analyze the activity of MutT homologue 1 (MTH1).
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