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Cobalt-60

HCID 61492
NotizenReaktionen
GrundinformationenÜberblickNamen und BezeichnerEigenschaftenSicherheit und RegulatorischesChemie und IndustrieZugehörige ReaktionenNotizen zur Verbindung
TeilstruktursucheÄhnliche Strukturen suchen

Grundinformationen

CAS
10198-40-0
Standard-SMILES
[60Co]
InChIKey
GUTLYIVDDKVIGB-OUBTZVSYSA-N
Summenformel
Co
Durchschnittliche Molmasse
59,9338 g/mol
Monoisotopische Masse
59,9338171

Überblick

Cobalt Co-60 is under investigation in clinical trial NCT02891083 (Adjuvant Therapies or Surgery Alone for High Risk pN0 Esophageal Cancer).

Namen und Bezeichner

Bevorzugter Name
Cobalt-60
IUPAC
cobalt-60
Englischer Name
cobalt
Summenformel
Co
Molmasse
58.93

Namen und Synonyme

Cobalt-60Cobalt Co-6060Co radioisotope10198-40-0Co-60 radioisotope60CoCobalt, isotope of mass 605C8182XDPZ(60Co)cobaltRefChem:127209COBALT 60UNII-5C8182XDPZ
Weitere Namen anzeigen
Co-6060mCo isotope60Co isotopeIsotope:60mCoIsotope:60CoCobalt-60m60mCo (isotope)Cobalt-60 isotope

Datenbank-Bezeichner

CAS
10198-40-0
PubChem CID
61492
DTXSID
DTXSID80891751
UNII
5C8182XDPZ

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA)
0 Ų
H-Brücken-Donoren
0
H-Brücken-Akzeptoren
0
Frei drehbare Bindungen
0
Schwere Atome
1
Formalladung
0
Komplexität
0

Experimentelle und physikochemische Eigenschaften

Chemical ClassesPhysical/Radiation -> Radionuclides
Physical DescriptionSilver-white metal;

Physikochemische Eigenschaften

Dichte
2.05 E-3 · 2.05E-3 g/cm3
EPA chemische Informationen
-60 · Cobalt-60 (10198-40-0)

Sicherheit und Regulatorisches

Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.

Gefahrenhinweise

Hazards Summary · 1 Eintrag

Source: Neutron activation of stable Co-59; Half-Life: 5.3 years Effective Half-Life: 10 days Specific Activity: 1,100 Ci/g Decay Mode: Beta GI Absorption: 5-30% Lung Clearance Half-Time: >100 days for oxides, hydroxides, halides, and nitrates; 10-100 days for other compounds; Critical Organ: Total body Internal Toxicity: High Annual Limit on Intake: 0.030 mCi Tenth-Value Layer: 34.8 mm Pb Gamma Ray Constant: 13.2 R/h @ 1 cm per mCi Radiation Energy (MeV): Beta 0.313 (99.8%); Gamma 1.17 (99.8%); Gamma 1.33 (100%) Radiation Accidents: 31 accidents reported with 211 injuries and 30 deaths plus C0-60 was involved in 16 incidents of Melting of Radioactive Materials; [See Glossary for references.] See Radiation, ionizing.

DOT Hazard Classification · 6 Einträge

Cobalt-60

Radioactive material

Atomic number: 27

Cobalt-60m

Radioactive material

Atomic number: 27

Sicherheit und Schutzausrüstung

Exposure Control and Personal ProtectionBiological Exposure Indices (BEI) [ACGIH] - Cobalt in urine = 15 ug/L; sample at end of shift at end of workweek;
Minimum Risk LevelChronic Inhalation: 0.0001 mg/m3 (L134) Intermediate Oral: 0.01 mg/kg/day (L134) Acute Radiation: 4 mSv (L134) Chronic Radiation: 1 mSv/yr (L134)

Toxikologische Informationen

TreatmentTreatment of cobalt poisoning is symptomatic. (L29)
Health Effects · 1 Eintrag

Exposure to high amount of cobalt can cause heart, lung, kidney, and liver damage. Skin contact is known to result in contact dermatitus. Cobalt may also have mutagenic and carcinogenic effects. Exposure to cobalt radiation causes cell damage and can lead to severe burns and death at high doses. (L29, L30)

Chemie und Industrie

Pharmakologische Informationen

Metabolism/Metabolites · 1 Eintrag

Cobalt is absorbed though the lungs, gastrointestinal tract, and skin. Since it is a component of the vitamin B12 (cyanocobalamin), it is distributed to most tissues of the body. It is transported in the blood, often bound to albumin, with the highest levels being found in the liver and kidney. Cobalt is excreted mainly in the urine and faeces. (L29)

Verwendung und Herstellung

Uses · 2 Einträge

Cobalt-59 is the naturally occurring stable form of cobalt. Of the 9 major radioactive isotopes, only Co-57 and Co-60 have half-lives longer than 80 days. Cobalt-60 is formed by neutron activation in nuclear reactors and particle accelerators. [Argonne] Co-60 is used in medicine for instrument sterilization and radiation therapy for cancer; Used in industrial radiography and irradiation of food and grain; [Waltar, Appendix A-D]

Radioactive cobalt is used for commercial and medical purposes, such as for sterilizing medical equipment and consumer products, radiation therapy for treating cancer patients, manufacturing plastics, and irradiating food. (L29)

Anwendungen · 1 Eintrag

Verwenden60Co (cobalt-60), a gamma and beta ray emitter with a half-life of about 5.3 years, is used in cancer therapy. Small pieces of radioactive metallic cobalt, made radioactive in a nuclear reactor, are placed into a proper shielding device and the radiation from them used in place of a high-powered x-ray machine or radium implantations in treating patients with localized cancer.

Anbieter1 Anbieter

时美拓特种气体(上海)有限公司18557025385 15757158480 · [email protected]

Zugehörige Reaktionen

1
Reaktionsaufzeichnung erstellen
Reaktionsgleichung von HRID 1973225
HRID 1973225als Katalysatoruspto-grants-1976_12

Notizen zur Verbindung

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Auf dieser SeiteGrundinformationenÜberblickNamen und BezeichnerEigenschaftenSicherheit und RegulatorischesChemie und IndustrieZugehörige ReaktionenNotizen zur Verbindung
Exposure RoutesInhalational (L29) ; oral (L29) ; dermal (L29); radiation (L29)
Toxicity Summary · 1 Eintrag

Cobalt is believed to exhibit its toxicity through a oxidant-based and free radical-based processes. It produces oxygen radicals and may be oxidized to ionic cobalt, causing increased lipid peroxidation, DNA damage, and inducing certain enzymes that lead to cell apoptosis. Cobalt has also been shown to block inorganic calcium channels, possibly impairing neurotransmission. Cobalt can also chelate lipoic acids, impairing oxidation of pyruvate or fatty acids. In addition, cobalt may inhibit DNA repair by interacting with zinc finger DNA repair proteins, and has also been shown to inhibit heme synthesis and glucose metabolism. Cobalt may activate specific helper T-lymphocyte cells and interact directly with immunologic proteins, such as antibodies (IgA and IgE) or Fc receptors, resulting in immunosensitization. Radioactive cobalt damages DNA, RNA, and lipids through ionizing events. (L29)

Signs and SymptomsExposure to cobalt radiation may cause acute radiation syndrome, which is characterized by nausea, vomiting, diarrhea, bleeding, and possibly coma. (L29)
Carcinogen ClassificationInternalized radionuclides that emit β particles are carcinogenic to humans (Group 1) (L2150). Cobalt-60 undergoes beta decay.
Toxicity DataLD50: 503 mg/kg (Oral, Rat) (A195) LD50: 25 mg/kg (Intravenous, Rabbit) (T14)

Sicherheitsdaten

ridadr
3332
hazard_class
7
packing_group
II