DL-Serin
SERINE · serin · DL-SER · 2-AMINO-3-HYDROXY-PROPIONIC ACID · DL-Serin · DL-Ser-OH · DL-SERINE · Serine, dl-
Identifikatoren & physikalische Daten
| CAS No. | 302-84-1 |
|---|---|
| Summenformel | C3H7NO3 |
| Durchschnittliche Molmasse | 105,09 g/mol |
| Monoisotopische Masse | 105,04259309 g/mol |
| SMILES | NC(CO)C(=O)O |
| InChIKey | MTCFGRXMJLQNBG-UHFFFAOYSA-N |
| PubChem CID | 617 |
| ChEBI | CHEBI:17822 |
| EC No. | 206-130-6 |
| DTXSID | DTXSID70859325 |
| Lokaler Name | DL-Serin |
Chemische & physikalische Eigenschaften
| XLogP | -3,1 |
|---|---|
| Polarare Oberfläche (TPSA) | 83,6 |
| H-Brücken-Donoren | 3 |
| H-Brücken-Akzeptoren | 4 |
| Frei drehbare Bindungen | 2 |
| Schwere Atome | 7 |
| Formalladung | 0 |
| Komplexität | 72 |
| Physical Description | Solid[Merck Index] Beige crystalline solid[Sigma-Aldrich MSDS] |
| Schmelzpunkt | 240 °C (dec.) (lit.) |
| Siedepunkt | 197.09°C (rough estimate) |
| Dichte | 1.53 |
| Brechungsindex | 1.4368 (estimate) |
| Lagerbedingungen | Store below +30°C. |
| Löslichkeit | H2O: soluble50.23 g/L (25 ºC) |
| Aggregatzustand | Crystalline Powder |
| pKa (Säurekonstante) | 2.19(at 25℃) |
| Farbe | White |
| Geruch | Odorless |
| Merck | 14,8460 |
| BRN | 1721402 |
| Henry-Konstante | 3.9×1010 mol/(m3Pa) at 25℃, Saxena and Hildemann (1996) |
| Kosmetik-Inhaltsstoffe Funktionen | FRAGRANCEHAIR CONDITIONINGANTISTATICSKIN CONDITIONING |
| InChI | 1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7) |
| InChIKey | MTCFGRXMJLQNBG-UHFFFAOYSA-N |
| SMILES | NC(CO)C(O)=O |
| LogP (Verteilungskoeffizient) | -3.460 |
| CAS Datenbank | 302-84-1(CAS DataBase Reference) |
| NIST chemische Informationen | DL-Serine(302-84-1) |
| EPA chemische Informationen | Serine (302-84-1) |
Sicherheit & Vorschriften
| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 99.6% (261 of 262) of all reports.Not ClassifiedReported as not meeting GHS hazard criteria by 261 of 262 companies (only 0.4% companies provided GHS information). For more detailed information, please visit ECHA C&L website.Aggregated GHS information provided per 262 reports by companies from 2 notifications to the ECHA C&L Inventory.Reported as not meeting GHS hazard criteria per 261 of 262 reports by companies.There is 1 notification provided by 1 of 262 reports by companies with hazard statement code(s).Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
|---|---|
| Regulatorische Informationen | Chemical: DL-SerineRegulation (EC) No 1831/2003 (amended)Status: Active Update: 12-08-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/21820Serine: Does not have an individual approval but may be used under an appropriate group standard |
| Weitere Sicherheitsinformationen | IMAP assessments - DL-Serine: Environment tier I assessmentEvaluation - Chemicals that are unlikely to require further regulation to manage risks to human health |
| Gefahrenübersicht | May cause irritation[Sigma-Aldrich MSDS] See L-Serine. |
| Hazard Classes and Categories | Not Classified |
| Wassergefährdungsklasse (WGK) | 3 |
| TSCA-Inventar-Status | TSCA listed |
| Zollcode | 29225000 |
| RTECS-Nr. | VT8100000 |
| R-Sätze (R) | 36/37/38 |
| Gefahrensymbole | Xi |
| Sicherheitshinweise (S) | 24/25-36-26 |
| Lagerklasse | 11 - Combustible Solids |
Anwendungen & Verwendung
Beschreibung
DL-Serine is a kind of neutral aliphatic amino acids containing hydroxyl groups with polarity but being uncharged, and belongs to nonessential amino acids for human body. It has a high content in sericin silk protein and fibroin protein. It can be formed from the methyl transfer reaction of glycine. It can also be converted to pyruvate or hydroxy pyruvate through deamination. It is also an important raw material for in vivo synthesis of choline and cysteine.
Verwenden
DL-Serine is used in the synthesis of novel tryptoline derivatives as IDO (indoleamine 2,3-Deoxygenase) inhibitors, for potential use in Alzheimer’s treatment.
Herstellung & Synthese
synthetische
DL-serine is obtained by complexing glycine under the catalysis of copper ions and then combining with formaldehyde under alkaline conditions, followed by acidification, ion exchange, and crystallization in ethanol.