Thorium-227

https://huagongshe.com/de/chemical/61806

Identifikatoren & physikalische Daten

CAS No.	15623-47-9
Summenformel	Th
Durchschnittliche Molmasse	227,0277 g/mol
Monoisotopische Masse	227,0277 g/mol
SMILES	[227Th]
InChIKey	ZSLUVFAKFWKJRC-FTXFMUIASA-N
PubChem CID	61806
DTXSID	DTXSID70891765

Chemische & physikalische Eigenschaften

Polarare Oberfläche (TPSA)	0
H-Brücken-Donoren	0
H-Brücken-Akzeptoren	0
Frei drehbare Bindungen	0
Schwere Atome	1
Formalladung	0
Komplexität	0

Sicherheit & Vorschriften

DOT Hazard Classification	Thorium-227Radioactive materialAtomic number: 90
Treatment	Treatment reversing the effects of irradiation is currently not possible. Anaesthetics and antiemetics are administered to counter the symptoms of exposure, as well as antibiotics for countering secondary infections due to the resulting immune system deficiency. (L1852)
Gesundheitliche Auswirkungen	Lungs and other internal organs can be penetrated by the alpha radiation produced by thorium. As a result, exposure to an aerosol of thorium can lead to increased risk of cancers of the lung, pancreas and blood. Exposure to thorium internally leads to increased risk of liver diseases. (L1094)
Expositionspfade	Oral (L1838)Inhalation (L1838)Dermal (L1838)
Toxizitätsübersicht	The ionizing radiation produced by thorium causes cellular damage that includes DNA breakage, accurate or inaccurate repair, apoptosis, gene mutations, chromosomal change, and genetic instability. This leads to loss of normal cell and tissue homeostasis, and development of malignancy. Ionizing radiation that does not directly damage DNA can produce reactive oxygen intermediates that directly affect the stability of p53, an important enzyme in cell-cycle regulation, and produce oxidative damage to individual bases in DNA and point mutations by mispairing during DNA replication. (L1837)
Signs and Symptoms	Exposure to high doses of ionizing radiation results in acute radiation syndrome, which can cause skin burns, hair loss, nausea, vomiting, dizziness, disorientation, low blood pressure, headache, fatigue, weakness, fever, birth defects, illness, infection, and death. (L1837, L1852)
Carcinogen Classification	1, carcinogenic to humans. (L135)

CAS No.

15623-47-9

Summenformel

Durchschnittliche Molmasse

227,0277 g/mol

Monoisotopische Masse

227,0277 g/mol

SMILES

[227Th]

InChIKey

ZSLUVFAKFWKJRC-FTXFMUIASA-N

PubChem CID

61806

DTXSID

DTXSID70891765

Polarare Oberfläche (TPSA)

H-Brücken-Donoren

H-Brücken-Akzeptoren

Frei drehbare Bindungen

Schwere Atome

Formalladung

Komplexität

Sicherheit & Vorschriften

DOT Hazard Classification

Thorium-227Radioactive materialAtomic number: 90

Treatment

Treatment reversing the effects of irradiation is currently not possible. Anaesthetics and antiemetics are administered to counter the symptoms of exposure, as well as antibiotics for countering secondary infections due to the resulting immune system deficiency. (L1852)

Gesundheitliche Auswirkungen

Lungs and other internal organs can be penetrated by the alpha radiation produced by thorium. As a result, exposure to an aerosol of thorium can lead to increased risk of cancers of the lung, pancreas and blood. Exposure to thorium internally leads to increased risk of liver diseases. (L1094)

Expositionspfade

Oral (L1838)Inhalation (L1838)Dermal (L1838)

Toxizitätsübersicht

The ionizing radiation produced by thorium causes cellular damage that includes DNA breakage, accurate or inaccurate repair, apoptosis, gene mutations, chromosomal change, and genetic instability. This leads to loss of normal cell and tissue homeostasis, and development of malignancy. Ionizing radiation that does not directly damage DNA can produce reactive oxygen intermediates that directly affect the stability of p53, an important enzyme in cell-cycle regulation, and produce oxidative damage to individual bases in DNA and point mutations by mispairing during DNA replication. (L1837)

Signs and Symptoms

Exposure to high doses of ionizing radiation results in acute radiation syndrome, which can cause skin burns, hair loss, nausea, vomiting, dizziness, disorientation, low blood pressure, headache, fatigue, weakness, fever, birth defects, illness, infection, and death. (L1837, L1852)

Carcinogen Classification

1, carcinogenic to humans. (L135)