Endrin ketone
Grundinformationen
- CAS
53494-70-5- Standard-SMILES
O=C1C2CC3C1C1(Cl)C(Cl)C4(Cl)C2C3C1(Cl)C4(Cl)Cl- InChIKey
IZHZFAQWVKBTSL-UHFFFAOYSA-N- Summenformel
- C12H8Cl6O
- Durchschnittliche Molmasse
- 380,9 g/mol
- Monoisotopische Masse
- 377,870631
Überblick
Endrin ketone is the chemical produced when endrin is exposed to light. Endrin is a chlorinated hydrocarbon used as an insecticide on cotton, maize, and rice. It also acts as an avicide and rodenticide. Due to its toxicity and tendency to bioaccumulate, its use is now banned in most parts of the world. (L111)
Namen und Bezeichner
- Bevorzugter Name
- Endrin ketone
- IUPAC
- 1,2,2,3,10,11-hexachloropentacyclo[5.4.1.03,10.04,12.05,9]dodecan-8-one
- Englischer Name
- ENDRIN KETONE
- Summenformel
- C12H8Cl6O
- Molmasse
- 380.91
Namen und Synonyme
Endrin ketone53494-70-5delta-Ketoendrindelta-Keto 153SD 2614.delta.-Ketoendrin1,2,2,3,10,11-hexachloropentacyclo[5.4.1.03,10.04,12.05,9]dodecan-8-one.delta.-Keto 1532,5,7-Metheno-3H-cyclopenta(a)pentalen-3-one, 3b,4,5,6,6,6a-hexachlorodecahydro-, (2-alpha,3a-beta,3b-beta,4-beta,5-beta,6a-beta,7-alpha,7a-beta,8R*)-2,5,7-Metheno-3H-cyclopenta(a)pentalen-3-one, 3b,4,5,6,6,6a-hexachlorodecahydro-, (2R,3aR,3bS,4R,5R,6aS,7S,7aR,8R)-rel-DTXSID00872845deltaKetoendrin
Weitere Namen anzeigen
sd2614KETOENDRINKETOENDERINδ-Ketoendrindelta-keto153Endrin Ketone 99%Endrin ketone (95-98%)ENDRIN KETONE STANDARD
1,2,2,3,10,11-hexachloropentacyclo(5.4.1.03,10.04,12.05,9)dodecan-8-onedeltaKeto 153RefChem:136814DTXCID208204042,5,7Metheno3Hcyclopenta(a)pentalen3one, 3b,4,5,6,6,6ahexachlorodecahydro, (2alpha,3abeta,3bbeta,4beta,5beta,6abeta,7alpha,7abeta,8R*)2,5,7Metheno3Hcyclopenta(a)pentalen3one, 3b,4,5,6,6,6ahexachlorodecahydro, (2R,3aR,3bS,4R,5R,6aS,7S,7aR,8R)relIZHZFAQWVKBTSL-UHFFFAOYSA-N7378-10-1
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 3,2
- Polarare Oberfläche (TPSA)
- 17,1 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 1
- Frei drehbare Bindungen
- 0
- Schwere Atome
- 19
- Formalladung
- 0
- Komplexität
- 564
Experimentelle und physikochemische Eigenschaften
PesticidesPesticides -> Organochlorine Pesticides
Physical DescriptionWhite solid; [Cerilliant MSDS]
Physikochemische Eigenschaften
- Siedepunkt
- 496.11 °C · 496.11°C (rough estimate)
- Dichte
- 1.5674 · 1.5674 (rough estimate)
- Brechungsindex
- 1.555 · 1.5550 (estimate)
- Flammpunkt
- 2 °C · 2 °C
- storage temp.
- 2 · 2-8°C
- Löslichkeit
- Chloroform (Slightly, Sonicated), Ethyl Acetate (Slightly)
- Major Application
- agriculture
- InChI
- 1S/C12H8Cl6O/c13-8-9(14)6-2-1-3(7(6)19)4-5(2)11(9,16)12(17,18)10(4,8)15/h2-6,8H,1H2/t2-,3+,4+,5-,6+,8+,9-,10+,11-/m1/s1
- InChIKey
- IZHZFAQWVKBTSL-YTMKBKNTSA-N
- SMILES
- Cl[C@@H]1[C@@]2(Cl)[C@H]3[C@@H]4C[C@@H]5[C@H]3[C@](Cl)(C2(Cl)Cl)[C@@]1(Cl)[C@@H]5C4=O
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
This chemical does not meet GHS hazard criteria for 2.4% (1 of 42) of reports.
Danger
H300 (97.6%): Fatal if swallowed [Danger Acute toxicity, oral]
P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 42 reports by companies from 3 notifications to the ECHA C&L Inventory.
Gefahrenhinweise
Hazards SummaryHighly toxic by ingestion; [Cerilliant MSDS] See Endrin.
Hazard Classes and CategoriesAcute Tox. 2 (97.6%)
Toxikologische Informationen
TreatmentTreatment is symptomatic, aimed at controlling convulsions, coma, and respiratory depression. If ingested, gastric lavage may be performed, followed by administering activated charcoal powder. (L150)
Health EffectsEndrin poisoning affects primarily the nerve system. Exposure causes various harmful effects including hyperexcitability, severe central nervous system damage, and death. Endrin is also believed to cause birth defects. (T10, L112)
Adverse EffectsOther Poison - Organochlorine
Exposure RoutesOral (L111)
Toxicity Summary
Endrin antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. Endrin also inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. Endrin also causes increased lipid peroxidation, decreased membrane fluidity, and DNA damage in hepatocytes, but the exact mechanism is unknown. (T10, L112)
Chemie und Industrie
Pharmakologische Informationen
Metabolism/Metabolites
Endrin is absorbed orally and distributed primarily to the fat and skin. The major biotransformation product is anti-l 2-hydroxyendrin and the corresponding sulfate, as well as glucuronide metabolites. Anti- and syn-12-hydroxyendrin and 12-ketoendrin are the main toxic metabolites of endrin. Endrin and its metabolites are excreted in urine and feces. (L112)
Verwendung und Herstellung
UsesEndrin is used as a pesticide. (L111)
Anbieter30 Anbieter
陕西缔都医药有限责任公司029-81124775 17791530730 · [email protected]
艾吉析科技（上海）有限公司17717235263 · [email protected]
江苏智芯廷科技有限公司18221391031 · [email protected]
广州佳途科技股份有限公司81960175-877 18933936954 · [email protected]
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
梯希爱（上海）化工贸易有限公司021-61109150 · [email protected]
上海稳同科技有限公司02151600108 13062666369 · [email protected]
上海毕楷科技有限公司
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