HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3,3'-Dimethoxybiphenyl-4,4'-ylendiammoniumdichlorid
O-DIANISIDINE DIHYDROCHLORIDE · 3,3'ODDI HCL · Fast Blue B.2HCl · 2-Dianisidinedi2HCl · DMB DIHYDROCHLORIDE · o-Dianisidine dihydr · O-DIANISIDINE REAGENT · 3,7'-DiMethoxybenzidine
Identifikatoren & physikalische Daten
| CAS No. | 20325-40-0 |
|---|---|
| Summenformel | C14H16N2O2.2HCl |
| Durchschnittliche Molmasse | 317,2 g/mol |
| Monoisotopische Masse | 316,07453318 g/mol |
| SMILES | COc1cc(-c2ccc(N)c(OC)c2)ccc1N.Cl.Cl |
| InChIKey | UXTIAFYTYOEQHV-UHFFFAOYSA-N |
| PubChem CID | 62311 |
| ChEMBL | CHEMBL1868992 |
| EC No. | 243-737-5 |
| DTXSID | DTXSID1020485 |
| Lokaler Name | 3,3'-Dimethoxybiphenyl-4,4'-ylendiammoniumdichlorid |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 70,5 |
|---|---|
| H-Brücken-Donoren | 4 |
| H-Brücken-Akzeptoren | 4 |
| Frei drehbare Bindungen | 3 |
| Schwere Atome | 20 |
| Formalladung | 0 |
| Komplexität | 236 |
| Löslichkeit | 10 to 50 mg/mL at 68 °F (NTP, 1992)H2O: soluble25mg/mL1-5 g/100 mL at 20 ºC |
| Schmelzpunkt | 514 °F (NTP, 1992)137 °C268 °C |
| Dampfdruck | 0.0000000088 [mm Hg] @25 °C |
| Physical Description | 3,3'-dimethoxybenzidine dihydrochloride is an off-white powder. (NTP, 1992)Wet SolidCBI |
| Flammpunkt | 206℃ |
| Lagerbedingungen | 2-8°C |
| Aggregatzustand | tablet |
| Farbe | Light beige to purple-gray |
| pH | 1.7 at 20℃ and 100g/L |
| BRN | 3917996 |
| Hauptanwendungen | diagnostic assay manufacturinghematologyhistology |
| InChI | InChI=1S/C14H16N2O2.ClH/c1-17-13-7-9(3-5-11(13)15)10-4-6-12(16)14(8-10)18-2/h3-8H,15-16H2,1-2H31H |
| InChIKey | UXTIAFYTYOEQHV-UHFFFAOYSA-N |
| SMILES | O(C1=C(C=CC(C2C=CC(N)=C(OC)C=2)=C1)N)C.Cl |
| CAS Datenbank | 20325-40-0(CAS DataBase Reference) |
| EPA chemische Informationen | 3,3'-Dimethoxybenzidine dihydrochloride (20325-40-0) |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]P203, P260, P264, P264+P265, P270, P280, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P318, P321, P330, P363, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 52 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Not Classified |
|---|---|
| Regulatorische Informationen | Hazard Traits - Carcinogenicity[1,1'-Biphenyl]-4,4'-diamine, 3,3'-dimethoxy-, hydrochloride (1:2) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of [1,1'-Biphenyl]-4,4'-diamine, 3,3'-dimethoxy-, hydrochloride (1:2) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 04-01-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/16226[1,1'-Biphenyl]-4,4'-diamine, 3,3'-dimethoxy-, dihydrochloride: Does not have an individual approval but may be used under an appropriate group standard |
| Brandgefahren | Flash point data are not available for this chemical, but it is probably combustible. (NTP, 1992) |
| Reaktive Gruppe | Ethers |
| Reactivity Profile | 3,3'-DIMETHOXYBENZIDINE DIHYDROCHLORIDE is an ether substituted acidic organic salt. Reacts weakly as a acid to neutralize bases. May react with strong oxidizing agents or strong reducing agents. |
| Air and Water Reactions | Water soluble. |
| Hazard Classes and Categories | Acute Tox. 4 (100%) |
| Brandbekämpfung | Fires involving this compound should be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992) |
| Erste Hilfe | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. |
| Freisetung ohne Brand | SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a strong soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. |
| Protective Action Criteria (PAC) | 5.8 [mg/m3]63 [mg/m3]380 [mg/m3] |
| Personal Protective Equipment (PPE) | MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves. |
| Carcinogen Classification | 3,3'-Dimethoxybenzidine DihydrochlorideTR-372: Toxicology and Carcinogenesis Studies of 3,3'-Dimethoxybenzidine Dihydrochloride (CASRN 20325-40-0) in F344/N Rats (Drinking Water Studies) (1990 )06/27/89Clear EvidenceChemical Not Tested in Species/Sex |
| Wassergefährdungsklasse (WGK) | 3 |
| TSCA-Inventar-Status | TSCA listed |
| UN-Transportnummer | 2811 |
| Zollcode | 29222990 |
| RTECS-Nr. | DD1050000 |
| R-Sätze (R) | 45-22 |
| Gefahrensymbole | T |
| Sicherheitshinweise (S) | 53-45 |
| Gefahrenklasse | 6.1(a)Acute Tox. 4 OralCarc. 1BEye Dam. 1Skin Corr. 1 |
| Verpackungsgruppe | II |
| Lagerklasse | 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects |
Anwendungen & Verwendung
Beschreibung
o-Dianisidine (dihydrochloride) is a colorimetric peroxidase substrate that has been used as a substrate to semi-quantitatively measure lactate, uric acid , and glucose. It has also been used as a reagent for the detection of various metals, thiocyanates, and nitrites. This aromatic amine is initially colorless but turns to violet upon oxidization and is spectrophotometrically measured at a wavelength of 405 nm.
Verwenden
It is suitable for use in ELISA procedures. In neurohistochemistry o-Dianisidine dihydrochloride has demonstrated perikaryal labeling as well as retrograde and anterograde transport to the primary olfactory cortex. It has also been used for a paper based-micro fluidic device to semi-quantitatively measure lactate, uric acid, and glucose. 3,3'-Dimethoxybenzidine is used principally as an intermediate in the production of commercial bisazobiphenyl dyes for coloring textiles, paper, plastic, rubber, and leather.