Grundinformationen
- CAS
69-05-6- Standard-SMILES
CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12.Cl.Cl- InChIKey
UDKVBVICMUEIKS-UHFFFAOYSA-N- Summenformel
- C23H32Cl3N3O
- Durchschnittliche Molmasse
- 472,9 g/mol
- Monoisotopische Masse
- 471,161096
Überblick
Quinacrine dihydrochloride appears as bright yellowish needles or bright yellow powder. Odorless. pH of a 1% aqueous solution is about 4.5.(NTP, 1992). Used as an anti-malarial drug. Moderately toxic.
Namen und Bezeichner
- Bevorzugter Name
- Quinacrine Dihydrochloride
- IUPAC
- 4-N-(6-chloro-2-methoxyacridin-9-yl)-1-N,1-N-diethylpentane-1,4-diamine;dihydrochloride
- Lokaler Name
- Chinacrin-dihydrochlorid
- Englischer Name
- Quinacrine dihydrochloride
- Summenformel
- C23H32Cl3N3O
- Molmasse
- 472.88
Namen und Synonyme
QUINACRINE DIHYDROCHLORIDE69-05-6Mepacrine dihydrochlorideCrinodoraItalchinMetochinMetoquinMetoquinePalacrinPalusanPentilenChemiochin
Weitere Namen anzeigen
QUINACRINEMEPACRINEATABRINEsn390erion866r.p.erionHCl
MalaricidaMethoquineMecrylChinacrin hydrochloride866 R.P.chinacrin2-Chloro-5-(omega-diethylamino-alpha-methylbutylamino)-7-methoxyacridine dihydrochlorideAcridine, 6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxy-, dihydrochloride
Datenbank-Bezeichner
- CAS
69-05-6- PubChem CID
- 6239
- DTXSID
DTXSID6025985- ChEMBL
CHEMBL2105615、CHEMBL554190- UNII
- 81A613ZZ6X
- EC Number
- 200-700-8
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 37,4 Ų
- H-Brücken-Donoren
- 3
- H-Brücken-Akzeptoren
- 4
- Frei drehbare Bindungen
- 9
- Schwere Atome
- 30
- Formalladung
- 0
- Komplexität
- 461
Experimentelle und physikochemische Eigenschaften
Solubility10 to 50 mg/mL at 64 °F (NTP, 1992)
Melting Point478 to 482 °F (Decomposes) (NTP, 1992)
Physical DescriptionQuinacrine dihydrochloride appears as bright yellowish needles or bright yellow powder. Odorless. pH of a 1% aqueous solution is about 4.5.(NTP, 1992). Used as an anti-malarial drug. Moderately toxic.
Collision Cross Section195.7 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
Physikochemische Eigenschaften
- Schmelzpunkt
- 249 · 249-251℃ (Decomposition)
- Dichte
- 1.2962 · 1.2962 (rough estimate)
- Brechungsindex
- 1.63 · 1.6300 (estimate)
- storage temp.
- 15 C · +15C to +30C
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly)
- pka
- -6.3 · pKa -6.3(H2O t undefined I not reported but low) (Uncertain)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 42 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Regulatory Information
6-chloro-N-[5-(diethylamino)pentan-2-yl]-2-methoxyacridin-9-amine dihydrochloride: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Other Safety InformationIMAP assessments - 1,4-Pentanediamine, N4-(6-chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-, dihydrochloride: Human health tier I assessment
Fire HazardsFlash point data for this chemical are not available, but it is probably combustible. (NTP, 1992)
Health HazardsSYMPTOMS: Symptoms of exposure to this compound include discoloration of the skin, sclera and urine, exfoliative dermatitis, acute hepatic necrosis, agranulocytosis, aplastic anemia, corneal edema and psychosis.
Reactive GroupAmines, Phosphines, and Pyridines
Reactivity ProfileQUINACRINE DIHYDROCHLORIDE is an acidic salt of an amine. React as a weak acid to neutralize bases.
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Agents used to treat tapeworm infestations in man or animals.
Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585)
Substances used in the treatment or control of nematode infestations. They are used also in veterinary practice.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Anwendungen
VerwendenQuinacrine dihydrochloride has been used:in its uptake and accumulation studies in mouse lung slices using fluorescence microscopein the staining of ATP vesicles in mesenchymal stem cells (MSCs)in uptake-release assay for characterization of dense granule functionality of platelets
Anbieter93 Anbieter
上海康恩博医药科技有限公司17510465506 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
艾吉析科技（上海）有限公司17717235263 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
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