Grundinformationen
- CAS
69-33-0- Standard-SMILES
Nc1ncnc2c1ccn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O- InChIKey
HDZZVAMISRMYHH-KCGFPETGSA-N- Summenformel
- C11H14N4O4
- Durchschnittliche Molmasse
- 266,25 g/mol
- Monoisotopische Masse
- 266,10150493
Überblick
Tubercidin is an N-glycosylpyrrolopyrimidine that is adenosine in which the in the 5-membered ring that is not attached to the ribose moiety is replaced by a carbon. Tubercidin is produced in the culture broth of Streptomyces tubericidus. It has a role as an antimetabolite, an antineoplastic agent and a bacterial metabolite. It is a ribonucleoside, a N-glycosylpyrrolopyrimidine and an antibiotic antifungal agent.
Namen und Bezeichner
- Bevorzugter Name
- Tubercidin
- IUPAC
- (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)oxolane-3,4-diol
- Lokaler Name
- 7-beta-D-Ribofuranosyl-7H-pyrrolo-(2,3-d)pyrimidin-4-amin
- Englischer Name
- TUBERCIDIN
- Summenformel
- C11H14N4O4
- Molmasse
- 266.25
Namen und Synonyme
tubercidin7-Deazaadenosine69-33-0Sparsomycin ATubercidineU-10071M351LCX45Y7H-Pyrrolo(2,3-d)pyrimidine, 4-amino-7-beta-D-ribofuranosyl-7-beta-D-Ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine4-Amino-7-beta-D-ribofuranosyl-7H-pyrrolo(2,3-d)pyrimidine7H-Pyrrolo(2,3-d)pyrimidin-4-amine, 7-beta-D-ribofuranosyl-7H-Pyrrolo(2,3-d)pyrimidine, 4-amino-7beta-D-ribofuranosyl-
Weitere Namen anzeigen
(2R,3R,4S,5R)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diolb120121CS-2599nsc56408ski26996Aids0519837-Deaza-Ar
CHEBI:48267DTXSID701018946NSC-564087-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amineU 10071(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)oxolane-3,4-diol(2R,3R,4S,5R)-2-{4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-5-(hydroxymethyl)oxolane-3,4-diolDeazaadenosine
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- -1,3
- Polarare Oberfläche (TPSA)
- 127 Ų
- H-Brücken-Donoren
- 4
- H-Brücken-Akzeptoren
- 7
- Frei drehbare Bindungen
- 2
- Schwere Atome
- 19
- Formalladung
- 0
- Komplexität
- 334
Experimentelle und physikochemische Eigenschaften
Drugs
Pharmaceuticals -> Antibiotics
Pharmaceuticals -> Listed in ZINC15
Physikochemische Eigenschaften
- Schmelzpunkt
- 247 · 247-248 °C (decomp)(Solv: water (7732-18-5))
- Siedepunkt
- 409.46 °C · 409.46°C (rough estimate)
- Dichte
- 1.2896 · 1.2896 (rough estimate)
- Brechungsindex
- 1.834 · 1.8340 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- Löslichkeit
- Soluble in DMSO
- Aggregatzustand
- powder
- pka
- 12.44 · 12.44±0.70(Predicted)
- Farbe
- off-white
- Merck
- 13 · 13,9875
- BRN
- 38498 · 38498
- Stabilität
- Hygroscopic
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Danger
H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]
P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 70 reports by companies from 2 notifications to the ECHA C&L Inventory.
Gefahrenhinweise
Regulatory Information7H-Pyrrolo2,3-dpyrimidin-4-amine, 7-.beta.-D-ribofuranosyl-: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and CategoriesAcute Tox. 2 (100%)
Sicherheitsdaten
- F
- 10
- wgk
- 3
- ridadr
- UN 3462 6.1/PG 2
- hs_code
- 29419090
- RTECS-Nr.
- UY8870000
- risk_code
- 28
- Toxizität
- LD50 i.v. in mice: 45 mg/kg (Anzai)
- hazard_code
- T+
- safety_code
- 36/37/39-45
- hazard_class
- 6.1(a)
- packing_group
- II
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.
Antimetabolites that are useful in cancer chemotherapy.
Anwendungen
VerwendenTubercidin is a nucleoside metabolite first isolated from Streptomyces tubericidus. Tubercidin, like other nucleosides, is a broad spectrum, potent chemotherapeutic agent active against viruses, bacteria, fungi, protozoans and tumours. Tubercidin acts at a diverse range of sites, such as RNA processing, nucleic acid and protein synthesis, and acts as a nucleoside mimic of adenosine.
Vor- und nachgelagerte Produkte
Nachgelagerte Produkte
Anbieter100 Anbieter
韶远科技(上海)有限公司4000665055 · [email protected]
南通飞宇生物科技有限公司0513-68819626 15152877458 · [email protected]
武汉敬康恩生物医药科技有限公司13720134139 086-15871494362 13720134139 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
成都彼样生物科技有限公司18108052721 · [email protected]
合肥翰刚医药科技有限公司
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