HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-Fluor-2,4-dinitrobenzol
DNF · DNFB · 1-FLUORO-2,4-DINITROBENZENE · DNPF · 4-fluoro-1,2-dinitrobenzene · FDNB · SANGER'S REAGENT · Dinitrofluorobenzene
Identifikatoren & physikalische Daten
| CAS No. | 70-34-8 |
|---|---|
| Summenformel | C6H3FN2O4 |
| Durchschnittliche Molmasse | 186,1 g/mol |
| Monoisotopische Masse | 186,0076848 g/mol |
| SMILES | O=[N+]([O-])c1ccc(F)c([N+](=O)[O-])c1 |
| InChIKey | LOTKRQAVGJMPNV-UHFFFAOYSA-N |
| PubChem CID | 6264 |
| ChEMBL | CHEMBL167423 |
| ChEBI | CHEBI:53049 |
| EC No. | 200-734-3 |
| DTXSID | DTXSID8025331 |
| Lokaler Name | 1-Fluor-2,4-dinitrobenzol |
Chemische & physikalische Eigenschaften
| XLogP | 1,6 |
|---|---|
| Polarare Oberfläche (TPSA) | 91,6 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 5 |
| Frei drehbare Bindungen | 0 |
| Schwere Atome | 13 |
| Formalladung | 0 |
| Komplexität | 224 |
| Stoffklassen | Nitrogen Compounds -> Nitros, Aromatic |
| SpringerMaterials Properties | Chemical shift |
| Dichte | 1.482 at 68 °F (NTP, 1992) - Denser than waterwill sinkDensity: 1.4718 g/cu cm at 54 °C1.482 g/mL at 25 °C (lit.) |
| Color/Form | Pale yellow crystals from ether |
| Löslichkeit | 0.1 to 1.0 mg/mL at 67.5 °F (NTP, 1992)Soluble in benzene, ether, propylene glycolSoluble in ethanolslightly soluble in chloroformIn water, 400 mg/L at 25 °Cchloroform: 0.1 g/mL, clear400 mg/L (25 ºC) |
| Flammpunkt | greater than 235 °F (NTP, 1992)Flash point > 113 °C>230 °F |
| Siedepunkt | 565 °F at 760 mmHg352 °F at 25 mmHg271 °F at 2 mmHg (NTP, 1992)296 °C178 °C/25 mmHg (lit.) |
| Decomposition | When heated to decomposition it emits toxic fumes of /nitrogen oxides/ & /fluorine/. |
| Schmelzpunkt | 81.5 to 86.0 °F (NTP, 1992)25.8 °C25-27 °C (lit.) |
| Dampfdruck | 0.0024 [mmHg] |
| Brechungsindex | Index of refraction: 1.5690 at 20 °Cn20/D 1.569(lit.) |
| Physical Description | 2,4-dinitrofluorobenzene appears as clear yellow crystals or yellow crystalline solid. (NTP, 1992)Pale yellow solid[Merck Index] Yellow low melting crystalline solidmp = 23-26 deg C[MSDSonline] |
| Lagerbedingungen | 2-8°C |
| Aggregatzustand | Liquid or Low Melting Crystals |
| Wichte | 1.482 |
| Farbe | Yellow to brownish |
| Merck | 14,4172 |
| BRN | 398632 |
| Henry-Konstante | 1.0×102 mol/(m3Pa) at 25℃, HSDB (2015) |
| Stabilität | Stable. Combustible. Incompatible with strong oxidizing agents, strong bases. |
| InChI | 1S/C6H3FN2O4/c7-5-2-1-4(8(10)11)3-6(5)9(12)13/h1-3H |
| InChIKey | LOTKRQAVGJMPNV-UHFFFAOYSA-N |
| SMILES | [O-][N+](=O)c1ccc(F)c(c1)[N+]([O-])=O |
| CAS Datenbank | 70-34-8(CAS DataBase Reference) |
| NIST chemische Informationen | Benzene, 1-fluoro-2,4-dinitro-(70-34-8) |
| EPA chemische Informationen | 2,4-Dinitrofluorobenzene (70-34-8) |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH301 (12%): Toxic if swallowed [Danger Acute toxicity, oral]P260, P261, P262, P264, P264+P265, P270, P271, P272, P280, P284, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P320, P321, P330, P332+P317, P333+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 50 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.WarningH315: Causes skin irritation [Warning Skin corrosion/irritation] |
|---|---|
| Regulatorische Informationen | Chemical: Benzene, 1-fluoro-2,4-dinitro-1-Fluoro-2,4-dinitrobenzene: Does not have an individual approval but may be used under an appropriate group standard |
| DOT-Kennzeichnung | Poison |
| Brandgefahren | This chemical is probably combustible. (NTP, 1992) |
| Gesundheitsgefahren | SYMPTOMS: Symptoms of exposure to this compound may include irritation to the eyes, skin and mucous membranes. |
| Gefahrenübersicht | A mutagen and sensitizer[RTECS] Emergency treatment: Methemoglobinemia[HSDB] A strong irritant and vesicant[HSDB] A skin, eye, and mucous membrane irritantThis chemical is highly toxic, a powerful irritant, and causes blistering. It caused allergic reactions and dermatitis by skin contact or inhalation. It can be absorbed through the skin. [CAMEO] A powerful irritant and vesicantMay be absorbed through skinMay cause skin and respiratory sensitization after prolonged contact[MSDSonline] |
| Reaktive Gruppe | Nitro, Nitroso, Nitrate, and Nitrite Compounds, Organic |
| Special Reports | REVIEW WITH 19 REFERENCES. DNFB IS WIDELY USED IN BIOCHEM RESEARCH & TEACHING FOR CHARACTERIZATION OF AMINES, ESP AMINO ACIDS, & FOR EXPTL IMMUNIZATION. EXPTL OBSERVATIONS & CLINICAL REPORTS ARE REVIEWED & FACTORS INFLUENCING (HUMAN) SENSITIZATION ARE DISCUSSED. RECOMMENDATIONS ARE GIVEN FOR PROPER USE OF PROTECTIVE GLOVES & AVOIDANCE OF SPRAY INHALATION.[THOMPSON JSEDMONDS OPSAFETY ASPECTS OF HANDLING THE POTENT ALLERGEN 1-FLUORO-2,4-DINITROBENZENEANN OCCUP HYG 23(1) 27 (1980)] |
| Reactivity Profile | Reacts with oxidizing agents (NTP, 1992). When air was admitted after vacuum evaporation of an ether peroxide solution, a violent explosion occurred. A halogenated aromatic nitro compound. Aromatic nitro compounds range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation. The aromatic nitro compounds may explode in the presence of a base such as sodium hydroxide or potassium hydroxide even in the presence of water or organic solvents. The explosive tendencies of aromatic nitro compounds are increased by the presence of multiple nitro groups. |
| DOT Emergency Guidelines | /GUIDE 152: SUBSTANCES - TOXIC (COMBUSTIBLE)/ Health: Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. /DinitrobenzenesDinitrobenzenes, liquidDinitrobenzenes, solid//GUIDE 152: SUBSTANCES - TOXIC (COMBUSTIBLE)/ Fire or Explosion: Combustible material: may burn but does not ignite readily. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. /Dinitrobenzenes/GUIDE 152: SUBSTANCES - TOXIC (COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. /Dinitrobenzenes/GUIDE 152: SUBSTANCES - TOXIC (COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLYit is not effective in spill situations where direct contact with the substance is possible. /DinitrobenzenesFor more DOT Emergency Guidelines (Complete) data for 1-FLUORO-2,4-DINITROBENZENE (8 total), please visit the HSDB record page. |
| Air and Water Reactions | Slightly soluble in water. |
| Hazard Classes and Categories | Acute Tox. 3 (12%)Skin corrosion/irritation - Category 2 |
| Shipment Methods and Regulations | No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article. |
| Brandbekämpfung | Fires involving this material can be controlled with a dry chemical, carbon dioxide, foam or Halon extinguisher. (NTP, 1992) |
| Erste Hilfe | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. |
| Freisetung ohne Brand | SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, you should dampen the solid spill material with alcohol, then transfer the dampened material to a suitable container. Use absorbent paper dampened with alcohol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with alcohol followed by washing with a strong soap and water solution. Do not reenter the contaminate area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. |
| Entsorgungsverfahren | SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal and plant lifeand conformance with environmental and public health regulations. |
| Isolation and Evacuation | Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: |
| Personal Protective Equipment (PPE) | MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves. |
| Wechselwirkungen | UV-IRRADIATION OF SKIN OR TOPICAL APPLICATION OF CORTICOSTEROIDS CAN CREATE LOCAL MILIEU IN WHICH 2,4-DININTRO-1-FLUOROBENZENE CANNOT FUNCTION AS EFFECTIVE STIMULATOR OF CONTACT HYPERSENSITIVITY.ANTIGENIC COMPETITION (DEPRESSED CONTACT SENSITIVITY TO PICRYL CHLORIDE) WAS INDUCED IN MICE BY PAINTING WITH DNFB (600 MUG) & BY IV, IP & ORAL ADMIN (600 MUG). ANTIGENIC COMPETITION ABOLISHED BY CYCLOPHOSPHAMIDE (5 MG, IP) GIVEN 4 DAYS AFTER IV DNFB (0 TO 600 MUG) OR 4-ETHOXYMETHYLENE 2-PHENYLOXAZOLONE (0 TO 600 MUG), & BY THYMECTOMY 6 WK PRIOR TO INJECTION OF DNFB. THYMUS-DERIVED SUPPRESSOR CELLS MAY BE INVOLVED IN ANTIGENIC COMPETITION INDUCED BY IV DNFB. IV DNFB DID NOT INDUCE CONTACT SENSITIVITY IN NORMAL MICE, AS IT DID IN MICE PRETREATED WITH CYCLOPHOSPHAMIDE 2 DAYS PRIOR TO INJECTION.SUPPRESSOR T CELLS ACTING ON EFFERENT PHASE (TS-EFF) OF DINITROFLUOROBENZENE-CONTACT SENSITIVITY WERE INDUCED-IN BALB/C MICE BY INJECTION OF DINITROBENZENESULFONATE (DNBSO3) & SUBSEQUENT PAINTING (SENSITIZATION) WITH DNFB. TS-EFF CELLS RELEASED SUPPRESSOR FACTOR, ANTIGEN & STRAIN SPECIFIC, WHICH WAS ACTIVE IN VIVO IN SENSITIZED RECIPIENTS. ADMIN OF DNBSO3 ALONE GENERATED SUPPRESSOR T CELLS, WHICH ACTED ONLY ON AFFERENT PHASE (TS-EFF). SUPPRESSOR T CELLS COULD NOT BE DETECTED IN MICE PAINTED WITH DNFB & DESENSITIZED LATER BY INJECTION OF DNBSO3.ANTIBODY MEDIATED & CELL MEDIATED IMMUNE FUNCTIONS OF OFFSPRING FROM NEW ZEALAND WHITE RABBITS FED CONTROL CHOW OR CHOW CONTAINING 10, 100 OR 250 PPM OF AROCLOR 1248 (PCB) WERE ASSESSED. ONLY OFFSPRING FROM MOTHERS FED 250 PPM HAD SIGNIFICANTLY LOWER CONTACT SENSITIVITY RESPONSE TO DNFB. THERE WAS NO DECR IN PLAQUE FORMING CELL RESPONSE TO SHEEP RED BLOOD CELLS (SRBC) OR SERUM ANTI-SRBC ANTIBODY TITERS AT ANY EXPOSURE LEVEL. SPLEEN & THYMUS DID NOT REVEAL ANY CHANGES IN CELLULARITY ASSOC WITH IMMUNOSUPPRESSIONNOR DID PERIPHERAL BLOOD LYMPHOCYTES DIFFER FROM CONTROLS.For more Interactions (Complete) data for 1-FLUORO-2,4-DINITROBENZENE (6 total), please visit the HSDB record page. |
| Umweltverhalten | TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 575(SRC), determined from a structure estimation method(2), indicates that 1-fluoro-2,4-dinitrobenzene is expected to have low mobility in soil(SRC). It has been shown that nitrobenzenes adsorb strongly to clay surfaces and the mobility of 1-fluoro-2,4-dinitrobenzene is expected to be low in soils rich in clay content(3,4). Volatilization of 1-fluoro-2,4-dinitrobenzene from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 9.8X10-8 atm-cu m/mole(SRC), using a fragment constant estimation method(2). 1-Fluoro-2,4-dinitrobenzene is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 2.4X10-3 mm Hg(SRC), determined from a fragment constant method(2). The half-life of 1-fluoro-2,4-dinitrobenzene in a dry silt loam soil was greater than 50 days(4) suggesting biodegradation occurs slowly in soil(SRC).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 575(SRC), determined from a structure estimation method(2), indicates that 1-fluoro-2,4-dinitrobenzene is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 9.8X10-8 atm-cu m/mole(SRC), developed using a fragment constant estimation method(2). According to a classification scheme(4), an estimated BCF of 7(SRC), from an estimated log Kow of 1.83(2) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Hydrolysis is not expected to be an important fate process for 1-fluoro-2,4-dinitrobenzene since this compound lacks functional groups that undergo hydrolysis under environmental conditions(3). The half-life of 1-fluoro-2,4-dinitrobenzene in a dry silt loam soil was greater than 50 days(7) suggesting biodegradation occurs slowly in water(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1-fluoro-2,4-dinitrobenzene, which has an estimated vapor pressure of 2.4X10-3 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1-fluoro-2,4-dinitrobenzene is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 420 days(SRC), calculated from its rate constant of 3.8X10-14 cu cm/molecule-sec at 25 °C(SRC) determined using a structure estimation method(2). 1-Fluoro-2,4-dinitrobenzene absorbs light greater than 290 nm(3) and may be susceptible to direct photolysis in sunlight(SRC). |
| Unerwünschte Wirkungen | Methemoglobinemia - The presence of increased methemoglobin in the bloodthe compound is classified as secondary toxic effect |
| Ongoing Test Status | The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical.[Available from: http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=70-34-8] |
| Soil Adsorption/Mobility | Using a structure estimation method based on molecular connectivity indices(1), the Koc for 1-fluoro-2,4-dinitrobenzene can be estimated to be 575(SRC). According to a classification scheme(2), this estimated Koc value suggests that 1-fluoro-2,4-dinitrobenzene is expected to have low mobility in soil. It has been shown that nitrobenzenes adsorb strongly to clay surfaces and the mobility of 1-fluoro-2,4-dinitrobenzene is expected to be low in soils rich in clay content(3,4). |
| Artificial Pollution Sources | 1-Fluoro-2,4-dinitrobenzene's production and use as an alkylating agent and reagent in elucidating amino acid sequence in proteins(1) may result in its release to the environment through various waste streams(SRC). |
| Environmental Biodegradation | AEROBIC: The half-life of 1-fluoro-2,4-dinitrobenzene in a dry silt loam soil was greater than 50 days(1) suggesting biodegradation occurs slowly in the environment(SRC). |
| Environmental Bioconcentration | An estimated BCF of 7 was calculated in fish for 1-fluoro-2,4-dinitrobenzene(SRC), using an estimated log Kow of 1.83(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low. |
| Volatilization from Water/Soil | The Henry's Law constant for 1-fluoro-2,4-dinitrobenzene is estimated as 9.8X10-8 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that 1-fluoro-2,4-dinitrobenzene is expected to be essentially nonvolatile from water surfaces(2). 1-Fluoro-2,4-dinitrobenzene's estimated Henry's Law constant(1) indicates that volatilization from moist soil surfaces is not expected to be an important environmental fate process(SRC). 1-Fluoro-2,4-dinitrobenzene is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 2.4X10-3 mm Hg(SRC), determined from a fragment constant method(1). |
| Non-Human Toxicity Excerpts | /LABORATORY ANIMALS: Acute Exposure/ ...TESTED IN RABBITS & RATS AT NEAR-LETHAL DOSES FOR TOXIC EFFECTS ON FUNDUS OF EYE, BUT NONE...DETECTED OPHTHALMOSCOPICALLY OR HISTOLOGICALLY. SURVIVING RABBIT RETINA IS DAMAGED IN VITRO AT CONCN OF 0.05 MOLAR./LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ SEVERAL GROUPS OF MICE (STRAINS SWISS, BALB/C OR C57BL/6) WERE ADMIN 1 TOPICAL DOSE OF 7,12-DIMETHYLBENZANTHRACENE (DMBA, 125 UG). IN MICE ADMIN 5 TOPICAL DOSES/WK OF 0.1% 1-FLUORO-2,4-DINITROBENZENE (DNFB) IN ACETONE SOLN, SKIN TUMORS DEVELOPED IN ONLY 4 WK IN SOME CASESAFTER 38 WK, THE TUMOR INCIDENCE WAS 70% (21/30 SWISS MICE). LOWER CONCN (0.03%) OF DNFB INDUCED TUMORS IN 38% OF 21 EVALUABLE DMBA-TREATED SWISS MICE. THE C57BL/6 MICE DEVELOPED FEWER TUMORS THAN THE SWISS OR BALB/C MICE AFTER TREATMENT WITH DMBA FOLLOWED BY EITHER DNFB OR CROTON OIL./GENOTOXICITY/ Dose-dependent mutagenicity demonstrated in ames test with samonella & was toxic at very high concn (100 nL/plate). Although, S9 metabolic activation fraction from rat liver blocked mutagenic activity of low concn & diminished toxicity, it did not affect mutagenicity at intermediate to high concn (approx 10-50 nL/plate)./GENOTOXICITY/ /SRP: GENOTOXIC/ POTENTIAL UTILIZING VARIOUS METHODS AVAIL IN V-79 CHINESE HAMSTER CELLS WAS INVESTIGATED. EXPOSURE DID NOT RESULT IN ANY UNSCHEDULED DNA SYNTH, NOR DID IT INCR FREQUENCY OF SISTER CHROMATID EXCHANGES IN V-79 CELLS IN PRESENCE OR ABSENCE OF RAT LIVER POSTMITOCHONDRIAL SUPERNATANT (S-15). FORWARD MUTATIONS, EITHER TO OUABAIN OR 6-THIOGUANINE RESISTANCE, WERE NOT INDUCED IN PRESENCE OR ABSENCE OF S-15. IT WAS ABLE TO INDUCE REVERSIONS IN METHIONINE-REQUIRING ESCHERICHIA COLI AUXOTROPHS IN DOSE-DEPENDENT FASHION & IT INHIBITED METABOLIC COOPERATION, IN DOSE-DEPENDENT MANNER, IN V-79 CELLS. ...For more Non-Human Toxicity Excerpts (Complete) data for 1-FLUORO-2,4-DINITROBENZENE (6 total), please visit the HSDB record page. |
| Environmental Abiotic Degradation | The rate constant for the vapor-phase reaction of 1-fluoro-2,4-dinitrobenzene with photochemically-produced hydroxyl radicals has been estimated as 3.8X10-14 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 420 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). 1-Fluoro-2,4-dinitrobenzene absorbs light greater than 290 nm and may be susceptible to direct photolysis in sunlight(SRC). Hydrolysis is not expected to be an important fate process for 1-fluoro-2,4-dinitrobenzene since this compound lacks functional groups that undergo hydrolysis under environmental conditions(3). |
| Probable Routes of Human Exposure | NIOSH (NOES Survey 1981-1983) has statistically estimated that 28 workers (0 of these were female) were potentially exposed to 1-fluoro-2,4-dinitrobenzene in the US(1). Occupational exposure to 1-fluoro-2,4-dinitrobenzene may occur through dermal contact with this compound at workplaces where 1-fluoro-2,4-dinitrobenzene is produced or used(SRC). |
| Wassergefährdungsklasse (WGK) | 3 |
| TSCA-Inventar-Status | TSCA listed |
| UN-Transportnummer | UN 3261 8/PG 2 |
| Zollcode | 29049085 |
| RTECS-Nr. | CZ7800000 |
| R-Sätze (R) | 22-33-34-42/43-40-23/24/25-43-36/38-36/37/38 |
| Gefahrensymbole | C,T,Xn |
| hazard_note | Toxic |
| Sicherheitshinweise (S) | 22-26-36/37/39-45-28A-23-7/9-36/37 |
| Gefahrenklasse | 6.1Acute Tox. 4 OralEye Irrit. 2Skin Irrit. 2Skin Sens. 1STOT RE 2STOT SE 3 |
| Verpackungsgruppe | III |
| Lagerklasse | 10 - Combustible liquids |
| Gefahrstoffdaten | 70-34-8(Hazardous Substances Data) |
Anwendungen & Verwendung
Beschreibung
Das 2,4-Dinitro-1-fluorbenzol bildet farblose, wasserunlösliche Kristalle. Die Verbindung besitzt sehr große Bedeutung in der Biochemie und dient zur Bestimmung von Aminosäuren, Aminozuckern, Morpholin und Phenolgruppen.
Verwenden
A substituted benzene use in polypeptide sequencing (also referred to as Sanger’s reagent). Used in the derivitization of primary amines. Shown to inhibit the reductase activity of mitochondrial b-c1 complex isolated from beef heart mitochondria.