Dinatrium-6,6'-dihydroxy-3,3'-(4,5,6,7-tetrabrom-1,3-dihydro-3-oxoisobenzofuran-1-yliden)dibenzolsulfonat

CRYSTALS

WHITE CRYSTALLINE POWDER

ALKALINE SOLN HAVE INTENSE BLUISH-PURPLE COLOR

ANIONIC PHTHALEIN DYE

HYGROSCOPIC

Danger

H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]

P233, P260, P261, P271, P272, P280, P284, P302+P352, P304+P340, P321, P333+P317, P342+P316, P362+P364, P403, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 41 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

SOLN SHOULD BE STORED IN WARM PLACE TO PREVENT CRYSTALLIZATION

INJECTION IS ADVERSELY AFFECTED BY & SHOULD BE PROTECTED FROM DIRECT SUNLIGHT

DEHYDROCHOLIC ACID, CHLORTETRACYCLINE, SULFONAMIDES, NOVOBIOCIN, & MONOAMINE OXIDASE INHIBITORS MAY ALSO INCR SULFOBROMOPHTHALEIN RETENTION, ALTHOUGH POSSIBILITY OF ACTUAL LIVER DAMAGE SHOULD BE CONSIDERED IN PT RECEIVING CHLORTETRACYCLINE, SULFONAMIDES, OR NOVOBIOCIN.

SIMULTANEOUS ADMIN OF INDOCYANINE GREEN...MAY RESULT IN IMPAIRMENT OF HEPATIC EXCRETION...

CHOLECYSTOGRAPHIC AGENTS...REPORTED TO COMPETITIVELY INTERFERE WITH SULFOBROMOPHTHALEIN CLEARANCE & EXCRETION... ETHOXAZENE, PHENAZOPYRIDINE, PHENOLPHTHALEIN, & PHENOLSULFONPHTHALEIN (PSP) MAY PRODUCE APPARENT DECR EXCRETION OF SULFOBROMOPHTHALEIN BY INTERFERING WITH COLORIMETRIC MEASUREMENT...

BILIARY EXCRETION RATE & RATE OF PLASMA DISAPPEARANCE OF SULFOBROMOPHTHALEIN... WERE SHOWN...TO INCR AFTER PRE-TREATMENT WITH PHENOBARBITAL & OTHER MICROSOMAL-ENZYME INDUCERS IN RATS, & INCR EXCRETION CORRELATED WELL WITH INCR IN BILE FLOW RATES.

For more Interactions (Complete) data for SODIUM SULFOBROMOPHTHALEIN (7 total), please visit the HSDB record page.

ANAPHYLACTIC REACTION...MAY BEGIN WITH BURNING SENSATION ON THE BODY & FLITTERING SCOTOMA, & PROGRESS TO SHOCK, DYSPNEA, CYANOSIS, RESPIRATORY & CARDIAC ARREST, PERIPHERAL CIRCULATORY COLLAPSE, PARALYSIS, UNCONSCIOUSNESS, CONVULSIONS, & COMA; BRONCHOSPASM HAS OCCURRED...

OTHER SIDE EFFECTS...INCL URTICARIA, PRURITUS, MALAISE, GENERALIZED FLUSHING, FAINTNESS, FEVER, CHILLS, NAUSEA, VOMITING, HYPOTENSION, TACHYCARDIA, VERTIGO, ECZEMA, SWEATING, LARYNGEAL STRIDOR, & WEAK PULSE. TRANSIENT NAUSEA IS ESP LIKELY TO OCCUR IN OVERWEIGHT PT.

...EXTRAVASATION OR INTRAARTERIAL INJECTION...WILL CAUSE SEVERE IRRITATION & NECROSIS IN SURROUNDING TISSUES. ACUTE LOCALIZED CONTACT DERMATITIS HAS BEEN REPORTED...

ANDROGENS & ANABOLIC STEROIDS, CERTAIN ESTROGENS...ORAL CONTRACEPTIVES, & B VITAMINS INTERFERE WITH...EXCRETION...MAY PRODUCE FALSE-POSITIVE TEST RESULT IN NEARLY ALL PT.

/IF EXTRAVASATION OCCURS/ EXTREMITY SHOULD BE ELEVATED & COLD COMPRESSES OR ICE PACKS APPLIED UNTIL ACUTE PAIN SUBSIDES. SC INJECTION OF 1% AQ PROCAINE HYDROCHLORIDE WILL STOP PAIN & REDUCE LIKELIHOOD OF VASOSPASM.

RESP & CARDIAC RESUSCITATION & SUPPORTIVE THERAPY, SUCH AS OXYGEN, SHOULD BE ADMIN AS NEEDED. ONLY AFTER ADEQUATE TISSUE OXYGENATION IS ASSURED & EPINEPHRINE ADMIN SHOULD HYDROCORTISONE, ANTIHISTAMINES, OR ADDITIONAL EPINEPHRINE BE ADMIN.

IF AN ANAPHYLACTIC REACTION OCCURS, SULFOBROMOPHTHALEIN ADMIN SHOULD BE DISCONTINUED IMMEDIATELY. BOTH SYSTEMIC & LOCAL SYMPTOMS HAVE BEEN REPORTED TO RESPOND PROMPTLY TO EPINEPHRINE & DIPHENHYDRAMINE.

IN ONE STUDY IN SMALL NUMBER OF NORMAL SUBJECTS, PLASMA HALF-LIFE AVG ABOUT 4 MIN. LIVER HAS STORAGE CAPACITY...WHICH IS PROPORTIONAL TO PLASMA CONCN OF DYE, & RANGES FROM 50-75 MG OF SULFOBROMOPHTHALEIN...PER MG OF DYE PER 100 ML OF PLASMA IN PT WITH NORMAL LIVER FUNCTION.

S-ARYLTRANSFERASE IS THOUGHT TO BE INVOLVED IN METABOLISM OF SULFOBROMOPHTHALEIN...

IT IS EXCRETED IN BILE OF RATS AS BSP-GLUTATHIONE & OTHER AMINOACYL CONJUGATES, FORMED BY CONDENSATION OF BSP WITH GLUTATHIONE, PROBABLY WITHOUT ELIMINATION OF ANY OF BROMINE ATOMS.

SULFOBROMOPHTHALEIN /WAS METABOLIZED TO THE FOLLOWING/ S-(3,3-BIS(4-HYDROXY-3-SULFOPHENYL) TRIBROMOPHTHALIDYL)GLUTATHIONE IN DOG; JAVITT NB, ET AL, J CLIN INVEST, 39, 1570 (1960). SULFOBROMOPHTHALEIN-BETA-D-GLUCURONIDE IN LIVER; HIRAYAMA C, ET AL, SAISHIN IGAKU, 17, 2520 (1962).

Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)

Chemicals and substances that impart color including soluble dyes and insoluble pigments. They are used in INKS; PAINTS; and as INDICATORS AND REAGENTS.

WHEN HEPATIC FUNCTION IS SEVERELY IMPAIRED, UP TO 10-25%...MAY BE EXCRETED IN URINE. NORMALLY...LESS THAN 2% OF DOSE IS EXCRETED IN THIS WAY, & EXTRAHEPATIC REMOVAL OF SULFOBROMOPTHALEIN CAN BE DISREGARDED.

NORMAL METABOLISM & EXCRETION OF SULFOBROMOPHTHALEIN DEPEND ON HEPATIC BLOOD FLOW, ABILITY OF LIVER CELLS TO TAKE UP & CONCN THE DYE, & INTAKE BILIARY EXCRETION.

...METABOLIZED IN LIVER BY CONJUGATION WITH GLUTATHIONE, & BOTH FREE & CONJUGATED...ARE EXCRETED INTO BILE. ... DYE DOES NOT UNDERGO ENTEROHEPATIC CIRCULATION...& IS EXCRETED PRIMARILY IN FECES. ... EXCRETION OF DYE IS USUALLY COMPLETE WITHIN 24 HR.

FOLLOWING IV ADMIN...ALMOST COMPLETELY BOUND TO PLASMA PROTEINS IN BLOOD, MAINLY ALBUMIN & ALPHA1 LIPOPROTEINS. DYE IS RAPIDLY TAKEN UP & BRIEFLY STORED BY HEPATIC PARENCHYMAL CELLS. ... SMALL AMT...MAY BE TAKEN UP BY SKELETAL MUSCLE, BUT EXTRA-HEPATIC TISSUE UPTAKE IS MINIMAL. ...DOES NOT CROSS PLACENTA.

For more Absorption, Distribution and Excretion (Complete) data for SODIUM SULFOBROMOPHTHALEIN (6 total), please visit the HSDB record page.

Used as a diagnostic aid for hepatic function; [Merck Index]

MEDICATION

MEDICATION (VET)

Benzenesulfonic acid, 3,3'-(4,5,6,7-tetrabromo-3-oxo-1(3H)-isobenzofuranylidene)bis[6-hydroxy-, disodium salt: INACTIVE

...ANIONIC PHTHALEIN DYE. ...COMMERCIALLY AVAIL AS SODIUM SALT... COMMERCIALLY AVAIL...INJECTION IS COLORLESS OR ALMOST COLORLESS SOLN HAVING PH OF 5-6.5. ... AN INDICATOR DYE. VERY SMALL DIFFERENCES IN PH AFFECT TINT...VARIATIONS OF TINT IN DIFFERENT LOTS OF COMMERCIALLY AVAIL SOLN ARE NOT OF ANY PRACTICAL SIGNIFICANCE.