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Diltiazem hydrochloride
DILTIAZEM HCL · DILTHIAZEM HYDROCHLORIDE · Tiazac · herbesser · Diltiazem Hydrochlorid · Sprix · Acuvail · cardizem
Identifikatoren & physikalische Daten
| CAS No. | 33286-22-5 |
|---|---|
| Summenformel | C22H27ClN2O4S |
| Durchschnittliche Molmasse | 451 g/mol |
| Monoisotopische Masse | 450,13800602 g/mol |
| SMILES | COc1ccc([C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O)cc1.Cl |
| InChIKey | HDRXZJPWHTXQRI-BHDTVMLSSA-N |
| PubChem CID | 62920 |
| ChEMBL | CHEMBL1697 |
| ChEBI | CHEBI:645509 |
| EC No. | 251-443-3 |
| DTXSID | DTXSID8040147 |
| Lokaler Name | Diltiazem hydrochloride |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 84,4 |
|---|---|
| H-Brücken-Donoren | 1 |
| H-Brücken-Akzeptoren | 6 |
| Frei drehbare Bindungen | 7 |
| Schwere Atome | 30 |
| Formalladung | 0 |
| Komplexität | 565 |
| Human Drugs | Breast FeedingLactationMilk, HumanAntihypertensive AgentsCalcium Channel BlockersAntiarrhythmicsVasodilator AgentsFDA approved drugs -> Active ingredient |
| Collision Cross Section | 196.1 Ų [M+H]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards] |
| Schmelzpunkt | 212-214 °C |
| Dichte | 1.30 g/cm3 |
| Brechungsindex | 118 ° (C=1, H2O) |
| Flammpunkt | 2℃ |
| Lagerbedingungen | 2-8°C |
| Löslichkeit | Freely soluble in water, in methanol and in methylene chloride, slightly soluble in anhydrous ethanol. |
| Aggregatzustand | Powder |
| Farbe | White to off-white |
| pH | pH (10g/l, 25℃) : 4.3～5.3 |
| Merck | 13,3226 |
| BRN | 4228706 |
| Stabilität | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
| Kosmetik-Inhaltsstoffe Funktionen | ASTRINGENTSKIN PROTECTING |
| InChI | 1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H31H/t20-,21+/m1./s1 |
| InChIKey | HDRXZJPWHTXQRI-BHDTVMLSSA-N |
| SMILES | Cl.COc1ccc(cc1)[C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O |
| CAS Datenbank | 33286-22-5(CAS DataBase Reference) |
| EPA chemische Informationen | 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, hydrochloride (1:1), (2S,3S)- (33286-22-5) |
Sicherheit & Vorschriften
| GHS-Einstufung | WarningH302 (99.2%): Harmful if swallowed [Warning Acute toxicity, oral]P203, P264, P270, P280, P301+P317, P318, P330, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 119 reports by companies from 16 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Regulatorische Informationen | Hazard Traits - Developmental ToxicityDiltiazem hydrochloride: Does not have an individual approval but may be used under an appropriate group standard |
| Weitere Sicherheitsinformationen | IMAP assessments - 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, monohydrochloride, (2S-cis)-: Environment tier I assessment |
| Hazard Classes and Categories | Acute Tox. 4 (99.2%) |
| Treatment | In the event of overdose or exaggerated response, appropriate supportive measures should be employed in addition to gastrointestinal decontamination. If bradycardia and/or high-degree AV block occurs, administer atropine (0.60 to 1.0 mg). If there is no response to vagal blockage, administer isoproterenol cautiously. Fixed high-degree AV block should be treated with cardiac pacing. In cases of cardiac failure, administer inotropic agents (isoproterenol, dopamine, or dobutamine) and diuretics. If hypotension occurs, use vasopressors (e.g. dopamine or levarterenol bitartrate). (L1712) |
| Gesundheitliche Auswirkungen | Because of its negative inotropic effect, diltiazem causes a modest decrease in heart muscle contractility and reduces myocardium oxygen consumption. Its negative chronotropic effect results in a modest lowering of heart rate, due to slowing of the sinoatrial node. It results in reduced myocardium oxygen consumption. Because of its negative dromotropic effect, conduction through the AV (atrioventricular) node is slowed, which increases the time needed for each beat. This results in reduced myocardium oxygen consumption. A reflex sympathetic response, caused by the peripheral dilation of vessels and the resulting drop in blood pressure, works to counteract the negative inotropic, chronotropic and dromotropic effects of diltiazem. Undesirable effects include hypotension, bradycardia, dizziness, and flushing. (Wikipedia) |
| Expositionspfade |
Anwendungen & Verwendung
Verwenden
An antianginal, antihypertensive. Regulates Calcium release from intracellular stores in neutrophils