Grundinformationen
- Standard-SMILES
CC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@H](N)c3ccccc3)[C@H]2SC1.Cl.O- InChIKey
YHJDZIQOCSDIQU-OEDJVVDHSA-N- Summenformel
- C16H20ClN3O5S
- Durchschnittliche Molmasse
- 401,9 g/mol
- Monoisotopische Masse
- 401,08121942
Überblick
Cephalexin Hydrochloride is the hydrochloride salt form of cephalexin, a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephalexin hydrochloride binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
Namen und Bezeichner
- Bevorzugter Name
- Cephalexin Hydrochloride
- IUPAC
- (6R,7R)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;hydrate;hydrochloride
- Englischer Name
- Cephalexin monohydrochloride
- Summenformel
- C16H17N3O4S.ClH.H2O
- Molmasse
- 401.87
Namen und Synonyme
Cephalexin hydrochlorideCephalexin HClKeftab105879-42-3Cefalexin hydrochlorideLY0611886VJE5G3D98LY-061188RefChem:57269Cephalexin Monohydrochloride7-(D-2-Amino-2-phenylacetamido)-3-methyl-3-cephem-4-carboxylic acid hydrochloride monohydrateCephalexin (hydrochloride monohydrate)
Weitere Namen anzeigen
cephalexin hydrochloride monohydrate5-Thia-1-azabicyclo4.2.0oct-2-ene-2-carboxylic acid, 7-(2R)-aminophenylacetylamino-3-methyl-8-oxo-, monohydrochloride, monohydrate, (6R,7R)-
(6R,7R)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;hydrate;hydrochlorideCephalexin monohydrochloride monohydrateKeftab (TN)(6R,7R)-7-((2R)-2-Amino-2-phenylacetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, monohydrochloride, monohydrateCephalexin hydrochloride [USAN]UNII-6VJE5G3D98(6R,7R)-7-[(2R)-2-Amino-2-phenylacetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, monohydrochloride, monohydrateCephalexin hydrochloride [USAN:USP]
Datenbank-Bezeichner
- CAS
105879-42-3- PubChem CID
- 62979
- DTXSID
DTXSID10909777- ChEMBL
CHEMBL1200366- UNII
- 6VJE5G3D98
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 139 Ų
- H-Brücken-Donoren
- 5
- H-Brücken-Akzeptoren
- 7
- Frei drehbare Bindungen
- 4
- Schwere Atome
- 26
- Formalladung
- 0
- Komplexität
- 600
Experimentelle und physikochemische Eigenschaften
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Sicherheit und Regulatorisches
Gefahrenhinweise
Regulatory Information
5-Thia-1-azabicyclo4.2.0oct-2-ene-2-carboxylic acid, 7-(2R)-aminophenylacetylamino-3-methyl-8-oxo-, monohydrochloride, monohydrate, (6R,7R)-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological ClassificationSubstances that inhibit the growth or reproduction of BACTERIA.
Anwendungen
VerwendenAntibacterial.
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