Methylprednisolone Aceponate
Advantan · SH-440 · ZK-91588 · ZK-91-588 · Aceponate · ZK-91588：SH-440 · Prednisolone Impurity 21 · METHYLPREDNISOLONE ACEPONATE
Identifikatoren & physikalische Daten
| CAS No. | 86401-95-8 |
|---|---|
| Summenformel | C27H36O7 |
| Durchschnittliche Molmasse | 472,6 g/mol |
| Monoisotopische Masse | 472,24610349 g/mol |
| SMILES | CCC(=O)O[C@]1(C(=O)COC(C)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C |
| InChIKey | DALKLAYLIPSCQL-YPYQNWSCSA-N |
| PubChem CID | 63019 |
| ChEMBL | CHEMBL1697782 |
| ChEBI | CHEBI:135762 |
| EC No. | 658-084-5 |
| DTXSID | DTXSID2023301 |
Chemische & physikalische Eigenschaften
| XLogP | 3,8 |
|---|---|
| Polarare Oberfläche (TPSA) | 107 |
| H-Brücken-Donoren | 1 |
| H-Brücken-Akzeptoren | 7 |
| Frei drehbare Bindungen | 7 |
| Schwere Atome | 34 |
| Formalladung | 0 |
| Komplexität | 979 |
| Schmelzpunkt | 105 - 108°C |
| Siedepunkt | 595.8±50.0 °C(Predicted) |
| Dichte | 1.23±0.1 g/cm3(Predicted) |
| Lagerbedingungen | Sealed in dry,Room Temperature |
| Löslichkeit | Chloroform (Slightly), Dioxane (Slightly), DMSO (Slightly), Ethyl Acetate(Slightly) |
| pKa (Säurekonstante) | 14.05±0.70(Predicted) |
| Aggregatzustand | Solid |
| Farbe | White to Off-White |
| InChIKey | DALKLAYLIPSCQL-TXWHWSFMNA-N |
| SMILES | O(C(CC)=O)[C@]1(C(COC(C)=O)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(C=C[C@]4(C)[C@H]3[C@H](C[C@]12C)O)=O |&1:5,15,16,18,25,27,28,30,r| |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH360 (96.4%): May damage fertility or the unborn child [Danger Reproductive toxicity]P203, P260, P264, P270, P280, P318, P319, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 28 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.WarningH361 (100%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity] |
|---|---|
| Hazard Classes and Categories | Repr. 1A (96.4%)Repr. 2 (100%) |
| Alarmwort | Warnung |
| Gefahrenhinweise | Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H361 |
Anwendungen & Verwendung
Beschreibung
Methylprednisolone aceponate (MPA) is a new potent topical corticosteroid. Chemically, it is a corticosteroid diester that penetrates the skin rapidly. It is rapidly metabolised and then conjugated, so although potent, it does not appear to cause serious local or systemic side effects. Clinical trials have shown that once daily use is sufficient to control most eczematous conditions and is also appropriate and effective in atopic dermatitis. MPA is effective in the treatment of facial and scalp eczema and sunburn and has shown promising results in the treatment of psoriasis. MPA is also suitable for use in children and infants. MPA is available in a wide range of formulations (0.1%) including creams, ointments, fat ointments, lotions and solutions depending on the patient's individual condition.
Verwenden
Methylprednisolone aceponate used in treatment of seborrhoeic dermatitis includes topical treatments such as corticosteroids, antifungals, metronidazole and pimecrolimus.