Bis(1-hydroxy-2(1H)-pyridinthiona-to-O,S)zink
ZPT · Pyrithione zinc · ZNPT · 1-HYDROXYPYRIDINE-2-THIONE ZINC · Bis[[(pyridine 1-oxide)-2-yl]thio] zinc salt · zincomadine · 2-MERCAPTOPYRIDINE N-OXIDE ZINC SALT · 1-HYDROXYPYRIDINE-2-THIONE ZINC SALT
Identifikatoren & physikalische Daten
| CAS No. | 13463-41-7 |
|---|---|
| Summenformel | C10H8N2O2S2Zn |
| Durchschnittliche Molmasse | 317,71 g/mol |
| SMILES | O[N+]1=CC=CCC1=S.On1ccccc1=S.[Zn] |
| PubChem CID | 6327770 |
| Lokaler Name | Bis(1-hydroxy-2(1H)-pyridinthiona-to-O,S)zink |
Chemische & physikalische Eigenschaften
| Schmelzpunkt | approximate 240℃ |
|---|---|
| Dichte | 1.782 g/cm3(Temp: 25 °C) |
| Dampfdruck | 0Pa at 25℃ |
| Lagerbedingungen | Sealed in dry,Room Temperature |
| Löslichkeit | almost transparency in PyridineInsoluble (<0.1 g/100 mL at 21 ºC) |
| Aggregatzustand | Powder |
| Farbe | White to Orange to Green |
| Geruch | Mild Characteristic |
| Merck | 14,7994 |
| Kosmetik-Inhaltsstoffe Funktionen | PRESERVATIVEHAIR CONDITIONINGANTI-SEBORRHEICANTI-SEBUM |
| InChI | InChI=1S/2C5H5NOS.Zn/c2*7-6-4-2-1-3-5(6)8/h2*1-4,8H/q+2/p-2 |
| InChIKey | OTPSWLRZXRHDNX-UHFFFAOYSA-L |
| SMILES | C1(C=CC=C[N+]=1[O-])S[Zn]SC1C=CC=C[N+]=1[O-] |
| LogP (Verteilungskoeffizient) | 0.9 at 25℃ and pH7.5-7.7 |
| Oberflächenspannung | 73mN/m at 7.22mg/L and 20℃ |
| CAS Datenbank | 13463-41-7(CAS DataBase Reference) |
| EPA chemische Informationen | Zinc pyrithione (13463-41-7) |
Sicherheit & Vorschriften
| Wassergefährdungsklasse (WGK) | 3 |
|---|---|
| TSCA-Inventar-Status | TSCA listed |
| UN-Transportnummer | UN 2811 6.1/PG 2 |
| Zollcode | 29333990 |
| RTECS-Nr. | ZH0950000 |
| R-Sätze (R) | 24/25-26-37/38-41-50/53-23-22 |
| Toxizität | LD50 oral in rat: 177mg/kg |
| Gefahrensymbole | T+,N,T |
| Sicherheitshinweise (S) | 26-28-36/37/39-45-61-60-39 |
| Gefahrenklasse | 6.1(b)Acute Tox. 2 InhalationAcute Tox. 3 OralAquatic Acute 1Aquatic Chronic 1Eye Dam. 1Repr. 1BSTOT RE 1 |
| Verpackungsgruppe | III |
| Lagerklasse | 6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials |
| Gefahrstoffdaten | 13463-41-7(Hazardous Substances Data) |
Anwendungen & Verwendung
Beschreibung
Zinc pyrithione is a coordination complex of zinc and pyrithione that has antimicrobial and anticancer activities. It is active against the bacteria E. coli, S. aureus, K. pneumoniae, A. baumannii, P. aeruginosa, E. faecium, E. faecalis, and E. cloacae (MICs = 1-4 μg/ml) and the fungus P. ovale when used at concentrations ranging from 0.01 to 10 μg/ml. Zinc pyrithione reduces tumor growth in an SCC-4 mouse xenograft model when administered at a dose of 1 mg/kg per week for six weeks. Formulations containing zinc pyrithione have been used in the treatment of dandruff.
Verwenden
Zinc pyrithione is directly cytotoxic and has antimicrobial effects. Zinc pyrithione is found in many shampoos (DHS-Zinc, Head and Shoulders) and should be applied for 5 minutes daily for 2 weeks. Zinc pyrithione is the active ingredient in several shampoos used to control dandruff and seborrheic dermatitis and is also effective in the therapy of tinea versicolor. It remains unclear whether the beneficial effects are caused by an antiproliferative or antimicrobial effect or both. It is substantive to the hair, allowing continued therapeutic effect after washing.