| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 1.1% (1 of 92) of reports.DangerH314 (47.8%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]P260, P261, P264, P264+P265, P271, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P319, P321, P332+P317, P362+P364, P363, P403+P233, P405, P501, and P502 (click each P-code to see the statement)Aggregated GHS information provided per 92 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
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| Regulatorische Informationen | Chemical: Methane, bromochloro-Methane, bromochloro- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Methane, bromochloro- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)TP - indicates a substance that is the subject of a proposed TSCA section 4 test rule.Status: Active Update: 19-12-2014 https://echa.europa.eu/registration-dossier/-/registered-dossier/7281Bromochloromethane: Does not have an individual approval but may be used under an appropriate group standardThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
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| Weitere Sicherheitsinformationen | IMAP assessments - Methane, bromochloro-: Environment tier II assessment |
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| DOT-Kennzeichnung | Poison |
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| Brandgefahren | Excerpt from ERG Guide 160 [Halogenated Solvents]:· Some of these materials may burn, but none ignite readily.Not combustible. Gives off irritating or toxic fumes (or gases) in a fire. Heating will cause rise in pressure with risk of bursting. |
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| Brandpotenzial | No flash or fire points by standard tests in air. |
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| Gesundheitsgefahren | Excerpt from ERG Guide 160 [Halogenated Solvents]:· Toxic by ingestion. |
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| Gefahrenübersicht | In animal studies, causes reversible liver injury, narcosis, and anesthesiaFire fighters exposed to high concentrations lost consciousness. [ACGIH] |
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| DOT-Nummer und Handbuch | 1887 160 |
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| Reaktive Gruppe | Halogenated Organic Compounds |
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| UN-Einstufung | UN Hazard Class: 6.1UN Pack Group: III |
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| TSCA-Anforderungen | Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Methane, bromochloro- is included on this list. Effective date: 6/1/87Sunset date: 12/19/95. |
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| OSHA Standards | Permissible Exposure Limit: Table Z-1 8-hr Time Weighted Avg: 200 ppm (1050 mg/cu m). |
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| Brandbekämpfung | Excerpt from ERG Guide 160 [Halogenated Solvents]:In case of fire in the surroundings, use appropriate extinguishing media. In case of fire: keep drums, etc., cool by spraying with water. |
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| Erste-Hilfe-Maßnahmen | Fresh air, rest. Half-upright position. Administration of oxygen may be needed. Artificial respiration may be needed. Refer for medical attention.Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention . |
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| Freisetungsmaßnahmen | · CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. |
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| Erste Hilfe | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.General First Aid:(General first aid procedures) |
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| Sichere Lagerung | Separated from food and feedstuffs, strong oxidizers, strong bases and metals. Ventilation along the floor. Do NOT store or transport in containers made from aluminium or plastic. |
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| Expositionsschutz und Persönliche Schutzausrüstung | · Wear positive pressure self-contained breathing apparatus (SCBA). |
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| Brandbekämpfungsverfahren | Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.If material involved in fire: Cool all affected containers with flooding quantities of water. Use water in flooding quantities as fog. Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Apply water from as far a distance as possible. Keep run off water out of sewers and water sources.Personnel protection: ... Wear positive pressure self-contained breathing apparatus when fighting fires involving this material.For more Fire Fighting Procedures (Complete) data for Bromochloromethane (6 total), please visit the HSDB record page. |
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| Lagerbedingungen | Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Light sensitive. Storage class (TRGS 510): Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effectsStore in a secure poison location. ... Chlorobromomethane must be stored to avoid contact with chemically active metals, since violent reactions occur. Store in tightly closed containers in a cool, well-ventilated area away from heat. |
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| Reinigungsverfahren | ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areasEnvironmental precautions: Do not let product enter drainsMethods and materials for containment and cleaning up: Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.1. Ventilate area of spill or leak. 2. Collect for reclamation or absorb in vermiculite, dry sand, earth, or similar material.Evacuate and restrict persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Ventilate area of spill or leak. Absorb liquids in vermiculite, dry sand, earth, peat, carbon, or a similar material and deposit in sealed containers. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. |
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| Freisetung ohne Brand | Excerpt from ERG Guide 160 [Halogenated Solvents]: |
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| Entsorgungsverfahren | SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in air, soil or watereffects on animal, aquatic and plant lifeand conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.Product: Offer surplus and non-recyclable solutions to a licensed disposal companyContaminated packaging: Dispose of as unused product.Chlorobromomethane may be disposed of by absorbing it in vermiculite, dry sand, earth, or a similar material, & disposing in a secured landfill.Incinerate together with flammable solvent in furnace equipped with afterburner and alkali scrubber.For more Disposal Methods (Complete) data for Bromochloromethane (6 total), please visit the HSDB record page. |
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| Verschüttetes entsorgen | Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. |
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| Zielorgane | Eyes, skin, respiratory system, liver, kidneys, central nervous system |
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| Ökotoxizitätswerte | LC50Species: Cyprinus carpio (Common Carp) eggsConditions: freshwater, static, 26 °C, dissolved oxygen > or =6.8 mg/LConcentration: 67000 ug/L for 3-5 days (95% confidence interval: 61000-95000 ug/L) |
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| Umweltverhalten | TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 22(SRC), determined from a structure estimation method(2), indicates that bromochloromethane is expected to have very high mobility in soil(SRC). Volatilization of bromochloromethane from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.46X10-3 atm-cu m/mole(SRC) based upon its vapor pressure, 142 mm Hg(3), and water solubility, 1.67X10+4 mg/L(4). Bromochloromethane is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). Utilizing the Japanese MITI test, 0% of the Theoretical BOD was reached in 4 weeks(5) indicating that biodegradation is not an important environmental fate process in soil(SRC).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 22(SRC), determined from a structure estimation method(2), indicates that bromochloromethane is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 1.46X10-3 atm-cu m/mole(SRC), derived from its vapor pressure, 142 mm Hg(4), and water solubility, 1.67X10+4 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 4 hrs and 5 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 4(SRC), from its log Kow of 1.41(7) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Utilizing the Japanese MITI test, 0% of the Theoretical BOD was reached in 4 weeks(8) indicating that biodegradation is not an important environmental fate process in water(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), bromochloromethane, which has a estimated vapor pressure of 142 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase bromochloromethane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 108 days(SRC), calculated from its rate constant of 8.80X10-14 cu cm/molecule-sec at 25 °C(3). The atmospheric lifetime is further reduced by ocean removal(4). On the basis of its water solubility and assuming that dissolution in the ocean leads to chemical degradation, the atmospheric lifetime will be reduced by approximately a factor of 2(4). Bromochloromethane does not absorb light at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). |
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| Unerwünschte Wirkungen | Neurotoxin - Acute solvent syndrome |
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| Expositionspfade | The substance can be absorbed into the body by inhalation, by ingestion and through the skin.inhalation, ingestion, skin and/or eye contact |
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| Toxizitätsübersicht | IDENTIFICATION AND USE: Chlorobromomethane is a colorless to pale-yellow liquid. The major use of chlorobromomethane is as fire-extinguishing fluid, particularly for aircraft and portable systems. It is also used as an explosion suppression agent, as a solvent, and as an intermediate in the manufacture of some insecticides (chlormephos). HUMAN EXPOSURE AND TOXICITY: Symptoms of exposure to chlorobromomethane include disorientationdizzinessirritation of the skin, eyes and throatpulmonary edemaheadacheanorexianauseavomitingabdominal painweight lossmemory impairmentparalysisweaknesstremorsconvulsionsand CNS depression. It may cause coughing, chest pain, and difficulty in breathing. It may also cause transient corneal epithelium damage. The compound is extremely destructive to tissue of the mucous membranes, upper respiratory tract, eyes, and skin. One firefighter's cornea was injured when a fire extinguisher containing chlorobromomethane and dichlorodifluoromethane was discharged close to his face. Soon thereafter partial loss of corneal epithelium was observed, but deeper layers of cornea remained clear. ANIMAL STUDIES: Exposure of rabbit eyes to a spray of liquid from fire extinguisher containing a mixture of 75% chlorobromomethane plus 25% dichlorodifluoromethane caused transient corneal epithelial injury and conjunctival edema. When applied repeatedly to open skin of rabbits, chlorobromomethane resulted in some hyperemia and exfoliation. When bandaged on, it produced moderate irritation and hyperemia. Concentrations as low as 3000 ppm produced light narcosis in rats. Transient pulmonary edema was observed at concentrations below 27,000 ppm. At higher concentrations, interstitial pneumonitis resulted in delayed deaths. Delayed deaths were also observed after exposure to 20,000 ppm. Deaths during exposure occurred only from exposures above 27,000 ppm. In dogs, acute exposures to high concentrations produced agitation, cardiac arrhythmias, myocardial sensitization to epinephrine, and epileptiform convulsions within 12 min. Chlorobromomethane was mutagenic toward Salmonella typhimurium strains TA100 and TA1535 which contains rat glutathione S-transferase 5-5. Reverse mutations were observed at the tyr locus in Escherichia coli WU361089 exposed at 10 uL/plate without activation. Prophage induction was also observed in E. coli K394 exposed without activation at 10 uL/plate. In an in vitro test with FAF-cells of Chinese hamsters, the compound produced an increase of the sister chromatid exchange frequency. |
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| Signs and Symptoms | Sore throat. Cough. Nausea. Headache. Shortness of breath. Dizziness. Drowsiness. Unconsciousness.Dry skin. Redness.Redness. Pain.Abdominal pain. Further see Inhalation.irritation eyes, skin, throatconfusion, dizziness, central nervous system depressionpulmonary edema |
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| Ongoing Test Status | EPA has released the Interactive Chemical Safety for Sustainability (iCSS) Dashboard. The iCSS Dashboard provides an interactive tool to explore rapid, automated (or in vitro high-throughput) chemical screening data generated by the Toxicity Forecaster (ToxCast) project and the federal Toxicity Testing in the 21st century (Tox21) collaboration. /The title compound was tested by ToxCast and/or Tox21 assays/[USEPAICSS Dashboard ApplicationAvailable from, as of December 17, 2015: http://actor.epa.gov/dashboard/] |
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| Effluent Concentrations | Bromochloromethane was analyzed for but not detected in leachate from reclaimed asphalt pavement collected from six different sites throughout Florida(1). |
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| ICSC Environmental Data | Avoid release to the environment because of its impact on the ozone layer. |
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| EPA IRIS Information | Bromochloromethane |
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| Medical Surveillance | The following medical procedures should be made available to each employee who is exposed to chlorobromomethane at potentially hazardous levels: Initial Medical Screening: Employees should be screened for history of certain medical conditions (listed below) which might place the employee at increased risk from chlorobromomethane. Skin disease: Chlorobromomethane can cause dermatitis on prolonged exposure. Persons with existing skin disorders may be more susceptible to effects of this agent. Liver disease: Although chlorobromomethane is not known as a liver toxin in humans, the importance of this organ in the biotransformation and detoxification of foreign substances should be considered before exposing persons with impaired liver function. Kidney disease: Although chlorobromomethane is not known as a kidney toxin in humans, the importance of this organ in the elimination of toxic substances justifies special consideration in those with impaired renal function. Chronic respiratory disease: In persons with impaired pulmonary function, especially those with obstructive airway disease, the breathing of chlorobromomethane might cause exacerbation of symptoms due to its irritant properties. 2. Periodic medical exam: Any employee developing the above listed conditions should be referred for further medical examination. |
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| Clean Water Act Anforderungen | Toxic pollutant designated pursuant to section 307(a)(1) of the Federal Water Pollution Control Act and is subject to effluent limitations. /Halomethanes/ |
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| Landesrichtlinien für Trinkwasser | (ME) MAINE 10 ug/L(FL) FLORIDA 90 ug/L |
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| Bundesrichtlinien für Trinkwasser | EPA 10 ug/L |
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| Alarmwort | Achtung |
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| Gefahrenhinweise | Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H315 |
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