Ethylamine

Nitrogen Compounds -> Amines, Aliphatic

Flammable agents - 4th degree

log Kow = -0.13

-0.13

-0.27/-0.08 (calculated)

0.687 at 59 °F (USCG, 1999) - Less dense than water; will float

0.689 g/cu cm at 15 °C

Relative density (water = 1): 0.7 (liquid)

Relative density (water = 1): 0.81

0.682-0.686 (10 °C)

0.69 (liquid)

Colorless gas or water-white liquid (below 62 degrees F) [Shipped as a liquefied compressed gas]

Volatile liquid or gas

Colorless liquid or gas, depending on the ambient temperature

Very soluble (NTP, 1992)

Miscible with water

Miscible with ethanol, ether

Solubility in water: miscible

Soluble in water

Soluble (in ethanol)

less than 0 °F (NTP, 1992)

less than 0 °F (NFPA, 2010)

Guide from Emergency Response Guidebook is for "Ethylamine, aqueous solution, with not less than 50% but not more than 70% Ethylamine." Flash point < 0 °F

-36.99 °C (-34.58 °F) - closed cup

<-17 °C (closed cup)

< 0 °F (<-18 °C) (open cup)

61.9 °F at 760 mmHg (NTP, 1992)

16.6 °C

16.00 to 17.00 °C. @ 760.00 mm Hg

16.6 °C

17 °C

17 °C

Danger

H220: Extremely flammable gas [Danger Flammable gases]

P203, P210, P222, P261, P264+P265, P271, P280, P304+P340, P305+P351+P338, P319, P337+P317, P377, P381, P403, P403+P233, P405, and P501 (click each P-code to see the statement)

Danger

H220 (88.7%): Extremely flammable gas [Danger Flammable gases]

P203, P210, P222, P260, P261, P262, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P330, P337+P317, P361+P364, P363, P377, P381, P403, P403+P233, P405, P410+P403, and P501 (click each P-code to see the statement)

Chemical: Ethanamine

List I Chemical: A chemical specified by regulation that, in addition to legitimate uses, is used in manufacturing a controlled substance in violation of the Act and is important to the manufacture of a controlled substance. (21 eCFR 1310.02)

Commission Regulation (EC) No 1565/2000 (Repealed by Com. Implementing Reg. (EU) No 872/2012)

Ethanamine is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Ethanamine are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 29-12-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/13596

Ethanamine, anhydrous (ethylamine): HSNO Approval: HSR001000 Approved with controls

Flammable Gas

Flammable Liquid Corrosive

Special Hazards of Combustion Products: Irritating and toxic oxides of nitrogen may be formed.

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

· Flammable/combustible material.

· EXTREMELY FLAMMABLE.

Extremely flammable. Gives off irritating or toxic fumes (or gases) in a fire. Gas/air mixtures are explosive.

Extremely flammable. Gives off irritating or toxic fumes (or gases) in a fire. Vapour/air mixtures are explosive.

A very dangerous fire hazard when exposed to heat or flame ... can react vigorously with oxidizing materials.

Vapor forms flammable mixtures with air.

Flammable gas above 62 °F (17 °C). ... Aqueous solutions are flammable unless diluted extensively.

Inhalation causes irritation of respiratory tract and lungs; pulmonary edema may result. Liquid causes severe irritation and burns of eyes and skin, and can permanently injure eyes after 15 seconds' contact. Ingestion causes severe burns of mouth and stomach; can be fatal. (USCG, 1999)

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

· May cause toxic effects if inhaled or ingested.

· May cause toxic effects if inhaled.

Liquid causes first degree burns on short exposure. [CHRIS] Corrosive to skin; [Quick CPC] Workers may develop eye irritation and corneal edema. Rabbits with inhalation exposure to 50 ppm have lung and corneal injury, while exposure to 100 ppm causes kidney injury; [ACGIH] Evaporating liquid can cause frostbite; [ICSC] Irritating to eyes and respiratory tract; Inhalation of 70% aqueous solution can cause chemical pneumonitis; [MSDSonline]

2270 132

1036 118

1036 118

Amines, Phosphines, and Pyridines

Amines, Phosphines, and Pyridines

Symbol: F+, Xi; R: 12-36/37; S: (2)-16-26-29

Symbol: F+, Xi; R: 12-36/37; S: (2)-16-26-29

UN Hazard Class: 2.1

UN Hazard Class: 3; UN Subsidiary Risks: 8; UN Pack Group: II

European Chemicals Bureau; IUCLID Dataset, Ethylamine (CAS # 75-04-7) (2000) describes information on usage patterns, ecotoxicity, and toxicity provided to the European Union by industry.

Dang Prop Ind Mater Rep 5 (5): 44-7 (1985). Reviews health hazards, toxicology, and safety of ethylamine.

Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Ethylamine is included on this list. Effective date: 6/1/87; Sunset date: 12/19/95.

Excerpt from ERG Guide 118 [Gases - Flammable - Corrosive]:

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

Shut off supply; if not possible and no risk to surroundings, let the fire burn itself out. In other cases extinguish with dry powder, carbon dioxide. In case of fire: keep cylinder cool by spraying with water. Combat fire from a sheltered position.

Use water spray, dry powder, alcohol-resistant foam. In case of fire: keep drums, etc., cool by spraying with water.

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.

ON FROSTBITE: rinse with plenty of water, do NOT remove clothes. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.

Rinse skin with plenty of water or shower. Refer for medical attention . Remove contaminated clothes.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

General First Aid:

General First Aid:

(General first aid procedures)

Fireproof. Cool.

Fireproof. Cool. Well closed. Separated from acids and oxidants.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear positive pressure self-contained breathing apparatus (SCBA).

5.0 [ppm]

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.

Gas: Do not extinguish fire unless the flow of gas can be stopped and any remaining gas is out of the line. Specially trained personnel may use fog lines to cool exposures and let the fire burn itself out ... Solution: Shut off supply. If not possible and no risk to surroundings, let fire burn itself out; in other cases use dry chemical, carbon dioxide.

To stop fire, stop flow of gas, use alcohol foam, dry chemical.

For more Fire Fighting Procedures (Complete) data for ETHYLAMINE (6 total), please visit the HSDB record page.

Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Gases

Ethylamine must be stored to avoid contact with strong acids (such as hydrochloric, sulfuric and nitric), or strong oxidizers (such as chlorine and bromine) because violent reactions occur. Store in tightly closed containers in a cool, well-ventilated area away from heat. Sources of ignition such as smoking and open flames are prohibited where methylamine is handled, used, or stored. Metal containers involving the transfer of 5 gallons or more of ethylamine should be grounded and bonded. Drums must be equipped with self-closing valves, pressure vacuum bungs, and flame arresters. Use only non-sparking tools and equipment, especially when opening and closing containers of ethylamine. Procedures for the handling, use and storage of cylinders should be in compliance with OSHA 1910.101 and 1910.169 as with the recommendations of the Compressed Gas Association.

Keep well closed and protected from light.

Separate from oxidizing materials, acids, and sources of halogens. Store in cool, dry, well-ventilated, noncombustible location.

Accidental release measures: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas.; Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains.; Methods and materials for containment and cleaning up: Clean up promptly by sweeping or vacuum.

Overspread /spill with/ sufficient sodium bisulfate and sprinkle /with/ water.

Eliminate all ignition sources. Approach release from upwind. Use water spray to cool and disperse vapors, protect personnel, and dilute spills, to form nonflammable mixtures. Absorb in noncombustible material for proper disposal. Control runoff and isolate discharged materials for proper disposal.

Environmental considerations-land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash, cement powder, or commercial sorbents. Apply "universal" gelling agent to immobilize spill. Neutralize with sodium bisulfate (NaHSO4).

For more Cleanup Methods (Complete) data for ETHYLAMINE (6 total), please visit the HSDB record page.

Excerpt from ERG Guide 118 [Gases - Flammable - Corrosive]:

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material.

Contaminated packaging: Dispose of as unused product.

Controlled incineration; incinerator is equipped with a scrubber or thermal unit to reduce nitrogen oxide emissions.

For more Disposal Methods (Complete) data for ETHYLAMINE (7 total), please visit the HSDB record page.

... The presence of volatile aliphatic amines ... in human breast milk and amniotic fluid /was measured/ to assess their role in neonatal hypergastrinemia. These volatile nitrogenous amino acid metabolites have been previously demonstrated to stimulate gastrin release in in vivo and in vitro laboratory preparations. ... The present study ... demonstrated that these gastrin-stimulatory volatile amines were present in significant concentrations in breast milk during the first several weeks after parturition and in amniotic fluid. The individual amines that were identified in both human milk and amniotic fluid samples were methylamine, dimethylamine, ethylamine, trimethylamine, propylamine, isobutylamine, and butylamine. This study provides indirect evidence to support the possibility that the hypergastrinemia measured in the fetus/neonate during the period immediately before and after birth may be attributable, in part, to the ingestion of fluid containing high concentrations of gastrin-stimulating amines.

Toxicity Threshold (Cell Multiplication Inhibition Test) Entosiphon sulcatum (protozoa) 45 mg/L /Conditions of bioassay not specified/

Toxicity Threshold (Cell Multiplication Inhibition Test) Uronema parduczi Chatton-Lwoff (protozoa) 3500 mg/L /Conditions of bioassay not specified/

Toxicity Threshold (Cell Multiplication Inhibition Test) Scenedesmus quadricauda (green algae) 2.3 mg/L /Conditions of bioassay not specified/

Toxicity Threshold (Cell Multiplication Inhibition Test) Microcystis aeruginosa (algae) 1.3 mg/L /Conditions of bioassay not specified/

For more Ecotoxicity Values (Complete) data for ETHYLAMINE (15 total), please visit the HSDB record page.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 7(SRC), determined from a log Kow of -0.13(2) and a regression-derived equation(3), indicates that ethylamine is expected to have very high mobility in soil(SRC). However, adsorption can be affected by the acidity of the soil; at a higher pH, cations have higher adsorption(SRC). The pKa of ethylamine is 10.87(4), indicating that this compound will exist almost entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5). Volatilization from moist soil is not expected because the compound exists as an cation and cations do not volatilize. Ethylamine is expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 1,048 mm Hg at 25 °C(6). Activated and non-activated sludge cultures were observed to degrade ethylamine rapidly(7-9); activated sludge acclimated to aniline resulted in a 34% theoretical BOD in 130 hours(8), indicating that biodegradation is an important environmental fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 7(SRC), determined from a log Kow of -0.13(2) and a regression-derived equation(3), indicates that ethylamine is not expected to adsorb to suspended solids and sediment(SRC). However, adsorption can be affected by the acidity of the substrate; at a higher pH, cations have higher adsorption(SRC). A pKa of 10.87(4) indicates ethylamine will exist almost entirely in the cation form at pH values of 5 to 9 and, therefore, volatilization from water surfaces is not expected to be an important fate process(SRC). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Activated and non-activated sludge cultures were observed to degrade ethylamine rapidly(6-8); activated sludge acclimated to aniline resulted in a 34% theoretical BOD in 130 hours(6), indicating that biodegradation is an important environmental fate process in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), ethylamine, which has a vapor pressure of 1,048 mm Hg at 25 °C(2), is expected to exist solely as a gas in the ambient atmosphere. Gas-phase ethylamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 14 hours(3), calculated from its rate constant of 2.77X10-11 cu cm/molecule-sec at 27 °C(4). Ethylamine does not contain chromophores that absorb at wavelengths >290 nm(5) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

Ethylamine occurrence in various foods(1)[Table#2152]

Ethylamine has been identified as a volatile component of boiled beef(1).

The substance can be absorbed into the body by inhalation.

The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

inhalation, skin absorption (liquid), ingestion (liquid), skin and/or eye contact (liquid)

Endogenous, Ingestion, Dermal (contact)

ENVIRONMENTAL: ... The presence of volatile aliphatic amines ... in human breast milk and amniotic fluid /was measured/ to assess their role in neonatal hypergastrinemia. These volatile nitrogenous amino acid metabolites have been previously demonstrated to stimulate gastrin release in in vivo and in vitro laboratory preparations. ... The present study ... demonstrated that these gastrin-stimulatory volatile amines were present in significant concentrations in breast milk during the first several weeks after parturition and in amniotic fluid. The individual amines that were identified in both human milk and amniotic fluid samples were methylamine, dimethylamine, ethylamine, trimethylamine, propylamine, isobutylamine, and butylamine. This study provides indirect evidence to support the possibility that the hypergastrinemia measured in the fetus/neonate during the period immediately before and after birth may be attributable, in part, to the ingestion of fluid containing high concentrations of gastrin-stimulating amines.

IDENTIFICATION AND USE: Ethylamine (EA) is a colorless gas or water-white liquid (below 62 degrees F). It is used in resin chemistry; as stabilizer for rubber latex; intermediate for dyestuffs, medicinals; in oil refining; in organic syntheses. EA has been identified as being used in hydraulic fracturing as a crosslinker. HUMAN EXPOSURE AND TOXICITY: Gas, vapor or liquid of aliphatic amines is highly irritating and can cause serious injuries to eyes or skin. Irritation of the respiratory tract can result in rhinorrhea, coughing, and dyspnea. Laryngospasm and signs of pulmonary edema (shortness of breath, cyanosis, and expectoration) may occur. For most exposed individuals symptoms will clear over several weeks or months. Survivors of severe inhalation injury, especially if chest x-ray and pulmonary function abnormalities are associated, may suffer residual chronic lung disease. In cases of eye contact with liquid aliphatic amines, permanent damage and impairment of vision can result. Ethylamine has been reported to cause adrenal cortical gland necrosis. Of the three adrenal gland areas, medulla, zona glomerulosa, and zona fasciculata/reticularis, the last is most sensitive to toxic injury, which is the case with ethylamine. Sensitivity of endocrine glands to toxic insult occurs in the following decreasing order: adrenal, testis, thyroid, ovary, pancreas, pituitary, and parathyroid. ANIMAL STUDIES: A 70% solution applied to the skin of guinea pigs resulted in prompt skin burns leading to necrosis; when it was held in contact with guinea pigs for 2 hr, there was severe skin irritation with extensive necrosis and deep scarring. When applied to the skin of a rabbit, a small amount of redness was produced, indicating the material to be only mildly irritating to the skin. After an inhalatory experiment in which rats were exposed for four hours to concentrations of 5000-12000 mg/cu m, ethylamine mainly acted on the eyes (swelling and milky look of the cornea, swollen eyes), nose (watery secretion), skin (etching effect on the eyelid), and the lungs (dyspnea). Morphological examination of the animals which died revealed an acute hyperemia in the brain and blood filled spots with border emphysema in the lung. Rabbits exposed 7hr/day, 5days/week for 6 weeks at 50 ppm ethylamine produced irritation of the lungs and eyes. The lung lesions included peribronchitis and pneumonitis with thickening of small blood vessels. The ocular changes involved multiple epithelial erosions and edema of the cornea along with edema of the nictitating membrane. Focal muscular degeneration of the heart was seen in some rabbits. After 14 days feeding experiments with 2.5% with mice and rats, mega mitochondria are induced. Oxidative phosphorylation is not changed and the mega mitochondria formation is reversible. EA was negative in the Salmonella typhimurium assay, Escherichia coli, and produced an increase in sister-chromatid exchanges in Chinese Hamster V79 cells.

Uremic toxins such as ethylamine are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins can stimulate the production of reactive oxygen species. This seems to be mediated by the direct binding or inhibition by uremic toxins of the enzyme NADPH oxidase (especially NOX4 which is abundant in the kidneys and heart) (A7868). Reactive oxygen species can induce several different DNA methyltransferases (DNMTs) which are involved in the silencing of a protein known as KLOTHO. KLOTHO has been identified as having important roles in anti-aging, mineral metabolism, and vitamin D metabolism. A number of studies have indicated that KLOTHO mRNA and protein levels are reduced during acute or chronic kidney diseases in response to high local levels of reactive oxygen species (A7869).

/OTHER TOXICITY INFORMATION/ ... There were very few data available on amines in surface waters, with reported concentrations often below detection and only rarely exceeding 10 ug/L. Reported concentrations for seawater and reservoirs were below detection or very low, while for lakes and rivers, concentrations spanned several orders of magnitude. The most prevalent and commonly detected amines were methylamine (MA), dimethylamine (DMA), ethylamine (EA), diethylamine (DEA) and monoethanolamine (MEAT). The paucity of data may reflect the analytical challenges posed by determination of amines in complex environmental matrices at ambient levels. We provide an overview of available aquatic toxicological data for amines and conclude that at current environmental concentrations, amines are not likely to be of toxicological concern to the aquatic environment, however, the potential for amines to act as precursors in the formation of nitrosamines and nitramines may represent a risk of contamination of drinking water supplies by these often carcinogenic compounds ...

Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Ethylamine is included on this list. Effective date: 6/1/87; Sunset date: 12/19/95.

This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Ethylamine is produced, as an intermediate or a final product, by process units covered under this subpart.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 100 lb or 45.4 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

Momoethylamine is designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes any isomers and hydrates, as well as any solutions and mixtures containing this substance.

Ethylamine

1

10000

Flammable chemical that can be released at a facility.

Monoethylamine is less readily metabolized than methylamine, and although a large portion may be destroyed, its nitrogen converted into urea, nearly one-third of the dose may be excreted unchanged by humans when administered as the hydrochloride.

In rats treated ip with N-ethylbenzamide (EB) at doses of 250-500 mg/kg, this amide was metabolized by hydrolysis to ethylamine and benzoic acid ...

Uremic toxins tend to accumulate in the blood either through dietary excess or through poor filtration by the kidneys. Most uremic toxins are metabolic waste products and are normally excreted in the urine or feces.

... Excreted /from the lung/ unchanged by /humans/.

Ethylamine has been identified as a normal constituent of mammalian and human urine.

Various amines were administered orally in the form of hydrochlorides to study the decomposition mechanisms of these compounds as well as their elimination conditions. The volatile alkyl amine nitrogen was measured daily in the urine. Alkyl amines which were eliminated were isolated as picrolonates and identified by melting point and nitrogen content. Only 1.74% to 1.93% of the administered methylamine was passed in the urine. Up to 32% and 14.9%, respectively, was recovered in the urine following dosing with ethylamine and isobutylamine. Up to 9.5% of administered propylamine was found in the urine and identified as a picrolonate. For dimethylamine and diethylamine, recovery in the urine the following day was 91.5% and 86.2%, respectively. /Amine hydrochlorides/

Used in the organic synthesis of dyes, medicines, resins, and other chemicals; Also used in oil refining and as a stabilizer of latex rubber; [Merck Index]

Petroleum Production and Refining [Category: Industry]

In resin chemistry; stabilizer for rubber latex; intermediate for dyestuffs, medicinals; in oil refining; in organic syntheses.

The principal use of monoethylamine is in the production of herbicides of the triazine type by reaction with cyanuric chloride.

CHEM INT FOR TRIAZINE HERBICIDES, INCL ATRAZINE, SIMAZINE; ETHYLAMINOETHANOL; 1,3-DIETHYLTHIOUREA, A CORROSION INHIBITOR; 4-ETHYLMORPHOLINE (URETHANE FOAM CATALYST); DIMETHYLOLETHYLTRIAZONE (WASH & WEAR AGENT): ETHYL ISOCYANATE

Dye intermediate, solvent extraction, petroleum refining, stabilizer for rubber latex, detergents, organic synthesis.

2023: 10,000,000 - <50,000,000 lb

(1971) 1.98X10+10 G

(1975) GREATER THAN 1.4X10+6 GRAMS

(1984) 2.23X10+10 g

(1985) 59,303X10+3 g

For more U.S. Production (Complete) data for ETHYLAMINE (8 total), please visit the HSDB record page.

Mono-, di-, and triethylamine can be produced from acetaldehyde, ammonia, and hydrogen in the presence of a hydrogenation catalyst.

Prepared from ethyliodide + liquid ammonia.

From ethyl chloride and alcoholic ammonia under heat and pressure.

Hydrogenation of nitroethane

Grades: Technical (anhydrous and 70% aq solution), pure, 98.5% minimum.

Available commercially as 50% or 70% aqueous solutions

Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes

Flavoring Agents -> JECFA Flavorings Index

Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes

Ethylamine and its salts

A chemical specified by regulation that, in addition to legitimate uses, is used in manufacturing a controlled substance in violation of the Act and is important to the manufacture of a controlled substance. (21 eCFR 1310.02)

All Other Basic Organic Chemical Manufacturing

Ethanamine: ACTIVE

Aziridines are hydrogenated in the presence of typical hydrogenation catalysts to give alkyl amines.

Each year, an estimated 35,000 wells are hydraulically-fractured in the U.S. Although the oil and gas extraction industry as a whole has a relatively higher fatality rate compared to most of the U.S. general industry... there is currently no worker injury/illness or fatality data publicly available for hydraulic fracturing or flowback operations. Regardless of the availability of data, more workers are potentially exposed to the hazards created by hydraulic fracturing and flowback operations due to the large increase in the number of these operations in the past decade. /Hydraulic fracturing/