6-(1-Hydroxyethyl)-4-methyl-7-oxo-3-({5-[(sulfamoylamino)methyl]pyrrolidin-3-yl}sulfanyl)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid--water (1/1)
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Grundinformationen
- CAS
364622-82-2- Standard-SMILES
C[C@@H](O)[C@H]1C(=O)N2C(C(=O)O)=C(S[C@@H]3CN[C@H](CNS(N)(=O)=O)C3)[C@H](C)[C@H]12.O- InChIKey
NTUBEBXBDGKBTJ-WGLOMNHJSA-N- Summenformel
- C15H26N4O7S2
- Durchschnittliche Molmasse
- 438,528 g/mol
- Monoisotopische Masse
- 438,12429117
Namen und Bezeichner
- Bevorzugter Name
- 6-(1-Hydroxyethyl)-4-methyl-7-oxo-3-({5-[(sulfamoylamino)methyl]pyrrolidin-3-yl}sulfanyl)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid--water (1/1)
- IUPAC
- (4R,5S,6S)-6-[(1R)-1-Hydroxyethyl]-4-methyl-7-oxo-3-({(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl}sulfanyl)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid--water (1/1)
- Englischer Name
- Doripenem hydrate
- Summenformel
- C15H26N4O7S2
- Molmasse
- 438.51
Namen und Synonyme
Finibax2H5]-DoripenemDoripeneM Crudedoripenem hydrateS 4661 monohydrateDoripene onohydrateDonipenan (monohydrate)Doripenem Hydrate (S 4661)Doripenem hydrate USP/EP/BPDoripenem monohydrate, >=99%
Datenbank-Bezeichner
- CAS
364622-82-2- PubChem CID
- 636377
- DTXSID
DTXSID60957788- ChEMBL
CHEMBL4303454- ChEBI
CHEBI:31518- UNII
- 4B035T6NKT
- EC Number
- 680-392-3
Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 173 °C · 173°C(dec.)(lit.)
- storage temp.
- 2 · 2-8°C
- Löslichkeit
- 2 O: · H2O: soluble5mg/mL, clear (warmed)
- Aggregatzustand
- powder
- Farbe
- white to beige
- PH
- 0.3 g · Dissolve 0.3g of Doripenem Hydrate in 30mL of water: the pH of the solution is between 4.5 and 6.0.
- Wasserlöslichkeit
- 2 O: · H2O: 5mg/mL, clear (warmed)
- BRN
- 15340136 · 15340136
- InChIKey
- NTUBEBXBDGKBTJ-WGLOMNHJSA-N
- SMILES
- C(C1=C([C@H](C)[C@]2([H])[C@@]([H])([C@H](O)C)C(=O)N12)S[C@@H]1CN[C@H](CNS(=O)(=O)N)C1)(=O)O.O |&1:3,5,7,9,16,19,r|
- CAS Datenbank
- 364622 · 364622-82-2(CAS DataBase Reference)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- 3
- hs_code
- 2935.90.9500
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Anwendungen
BeschreibungDoripenem hydrate is a carbapenem derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of infections such as HOSPITAL-ACQUIRED PNEUMONIA, and complicated intra-abdominal or urinary-tract infections, including PYELONEPHRITIS.Doripenem hydrate was first approved by Pharmaceuticals and Medical Devices Agency of Japan (PMDA) on July 25, 2005, then approved by the U.S. Food and Drug Administration (FDA) on Oct 12, 2007, and approved by European Medicines Agency (EMA) on July 25, 2008. It was developed by Shionogi and Janssen, then marketed as Finibax® in Japan and as Doribax® in the US by Shionogi and as Doribax® by Janssen in BE.
VerwendenDoripenem (doripenem monohydrate) is an ultra-broad spectrum injectable antibiotic. It is a beta-lactam and belongs to the subgroup of carbapenems. It is particularly active against Pseudomonas aeruginosa
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