Dichlorethan

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]:

Use water spray, foam, powder, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Refer for medical attention .

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

General First Aid:

(General first aid procedures)

Vapors are heavier than air and will collect in low areas. Vapors may travel long distances to ignition sources and flashback. Vapors in confined areas may explode when exposed to fire. Containers may explode in fire. Storage containers and parts of containers may rocket great distances, in many directions.

· Wear positive pressure self-contained breathing apparatus (SCBA).

51.88 [ppm]

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Advice for firefighters: Wear self contained breathing apparatus for fire fighting if necessary.

Use water spray to cool unopened containers.

To fight fire use alcohol foam, water, foam, /carbon dioxide/, dry chemical.

For more Fire Fighting Procedures (Complete) data for 1,1-Dichloroethane (7 total), please visit the HSDB record page.

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Store in a flammable liquid storage area or approved cabinet away from ignition sources and corrosive and reactive materials. ... Before entering confined space where this chemical may be present, check to make sure that an explosive concentration does not exist. 1,1-Dichloroethane must be stored to avoid contact with strong oxidizers, such as chlorine, bromine, and fluorine, since violent reactions occur. Store in tightly closed containers in a cool, well-ventilated area away from heat. Sources of ignition, such as smoking and open flames are prohibited where 1,1-dichloroethane is used, handled, or stored in a manner that could create a potential fire or explosion hazard. Metal containers used in the transfer of 5 gallons or more of 1,1-dichloroethane should be grounded and bonded. Drums must be equipped with self-closing valves, pressure vacuum bungs, and flame arresters. Use only nonsparking tools and equipment, especially when opening and closing containers of 1,1-dichloroethane.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations.

1. Remove all ignition sources. 2. Ventilate area of spill or leak. 3. For small quantities, absorb on paper towels. Evaporate in a safe place (such as a fume hood). Allow sufficient time for evaporating vapors to completely clear the hood ductwork. Burn the paper in a suitable location away from combustible materials. Large quantities can be reclaimed or collected and atomized in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device. 1,1-Dichloroethane should not be allowed to enter a confined space, such as a sewer, because of the possibility of an explosion. Sewers designed to preclude the formation of explosive concn of 1,1-dichloroethane vapors are permitted.

Evacuate and restrict persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Establish forced ventilation to keep levels below explosive limit. Absorb liquids in vermiculite, dry sand, earth, peat, carbon, or a similar material and deposit in sealed containers. Keep this chemical out of confined space, such as a sewer, because of the possibility of an explosion, unless the sewer is designed to prevent the buildup of explosive concentrations. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters.

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U076, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material; Contaminated packaging: Dispose of as unused product.

Potential candidate for liquid injection incineration, with a temperature range of 650 to 1,600 °C and a residence time of 0.1 to 2 seconds. Also a potential candidate for rotary kiln incineration, with a temperature range of 820 to 1600 °C and a residence time of seconds. Also a potential candidate for fluidized bed incineration, with a temperature range of 450 to 980 °C and a residence time of seconds.

The following wastewater treatment technologies have been investigated for 1,1-dichloroethane: Concentration process: Stripping.

For more Disposal Methods (Complete) data for 1,1-Dichloroethane (10 total), please visit the HSDB record page.

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

ATSDR Toxicological Profile for 1,1-Dichloroethane - Succinctly characterizes the toxicologic and adverse health effects information.

Ranking: 31 (total points: 1353.3)

Ranking: 254 (total points: 807.47)

A trace of 1,1-dichloroethane was found in exhaled air from 1 of 9 Love Canal, NY residents tested(1). A trace of 1,1-dichloroethane was found on the breath of 8 healthy volunteers employed at the US Air Force School of Aerospce Medicine, TX that had no special exposure to chemicals(2).

A National Health and Nutrition Survey (NHANES) of the U.S. population in 2003-2004 screened for 1,1-dichloroethane in blood from 1,367 participants (670 males and 679 females) in the age range of 20-59 years old; the portion of the data below the limit of detection (LOD of 0.01 ug/L) was too high to provide valid results for a background level in blood(1). The geometric mean of the 2005-2006 NHANES sampling of blood from 3,193 participants was <0.01 ug/L (limit of detection(1).

Following oral exposure, immediately dilute with 4 to 8 ounces (120 to 240 mL) of water or milk and administer charcoal as a slurry (240 mL water/30 g charcoal). Consider insertion of a small, flexible nasogastric or orogastric tube to suction gastric contents after recent large ingestions (the risk of further mucosal injury must be weighed against potential benefits). Following inhalation exposure, Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. After eye exposure, irrigate exposed eyes with copious amounts of room temperature water for at least 15 minutes. If the exposure occurs through dermal contact, remove contaminated clothing and wash exposed area thoroughly with soap and water. In any case, a physician may need to examine the area if irritation or pain persists. (T36)

Drinking water chlorination results in numerous chlorinated byproducts. We evaluated the developmental and embryo toxicity of 1,3-dichloropropane (1,3DP), 2,2-dichloropropane (2,2DP), 1,1-dichloroethane (1,1DE) and 1,1,2,2-tetrachloroethane (TCE) in rat whole embryo culture (WEC) due to their presence in chlorinated drinking water, their structural similarities, and a lack of developmental toxicity data for these compounds. Humans could be exposed to these four chlorinated propanes and ethanes (CPEs) simultaneously in drinking water and hence we evaluated them alone and in combination. Toxicity profiles were generated by exposing gestational day (GD) 9.5 rat embryos in WEC to the CPEs for 48 hours. The individual CPEs were all dysmorphogenic in WEC and embryonic exposure resulted primarily in rotation and heart defects. The embryonic effects from exposure were compared based on developmental score (DEVSC), death and dysmorphology as the parameters of comparison. Concentrations of individual CPEs chosen for the mixture studies were predicted to produce DEVSCs 25% below control values. These equipotent mM concentrations (14.5 1,1DE, 1.5 TCE, 16 2,2DP, 5.5 1,3DP) were then used to determine the toxicity of all possible combinations, based on a dose-additivity model, of the four CPEs. Eight of mixture combinations gave experimental DEVSCs which were not significantly different from the predicted scores while three of the mixtures (1,3DP/2,2DP; TCE/1,3DP/2,2DP; TCE/1,3DP/2,2DP/1,1DE) gave scores which were significantly lower than predicted. Embryo mortality was additive in ten of the eleven treatment groups, with one mixture significantly more embryotoxic (27% mortality) than predicted. Dysmorphology was significantly elevated in all treatment groups compared to controls and was neither significantly different between the groups nor different from dysmorphology seen in embryos following exposure to the individual compounds. These data suggest that the developmental toxicity of these halogenated propanes and ethanes is additive.

Laboratory investigations were carried out on 280 workers exposed to vinyl chloride and dichloroethane. Some hematological indices and liver function were examined. ... A ... case of vinyl chloride disease was diagnosed in which the combined effect of vinyl chloride and dichloroethane was apparent.

Neurological (Nervous System), Renal

Skin, liver, kidneys, lungs, central nervous system

1,1-dichloroethane can cause kidney disease after long-term, high-level exposure in the air. It is also known to cause liver damage, as well as central nervous system depression. 1,1-Dichloroethane can cause dermatitis on prolonged dermal exposure. (L403, T65)

LC50; Species: Poecilia reticulata (guppies); Concentration: 202 ppm for 7 days /Conditions of bioassay not specified/

EC50; Species: Pseudokirchneriella subcapitata (Green Algae) 15000 cells/mL; Conditions: freshwater, static, 24 °C; Concentration: 42920 ug/L for 48 hr; Effect: decreased population growth rate

Aquatic and Atmospheric Fate: Chloroethanes are expected to be present in industrial air and water emissions. They volatilize rapidly from surface water and persist in urban atmospheres. Hydrolysis and biodegradation are expected to be slow. /Chloroethanes/

TERRESTRIAL FATE: Based on a classification scheme(1), measured Koc values of 30(2) and 9.2(3) indicate that 1,1-dichloroethane is expected to have very high mobility in soil(SRC). Volatilization of 1,1-dichloroethane from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 5.62X10-3 atm-cu m/mole(4). 1,1-Dichloroethane is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 227 mm Hg at 25 °C(5). The half-life of 1,1-dichloroethane under sulfate-reducing conditions was approximately 115 days using well monitoring data from a landfill with a contamination history(6), indicating that biodegradation is a slow environmental fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), measured Koc values of 30(2) and 9.2(3) indicate that 1,1-dichloroethane is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(4) based upon a Henry's Law constant of 5.62X10-3 atm-cu m/mole(5). Using this Henry's Law constant and an estimation method(4), volatilization half-lives for a model river and model lake are 3 hrs and 4 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 7(SRC), from its log Kow of 1.79(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is low(SRC). The half-life of 1,1-dichloroethane under sulfate-reducing conditions was approximately 115 days using well monitoring data from a landfill with a contamination history(9), indicating that biodegradation is a slow environmental fate process in water(SRC). Hydrolysis is not expected to be an important environmental fate process(SRC) given a hydrolysis half-life of 61.3 years at 25 °C and pH 7(10).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1,1-dichloroethane, which has a vapor pressure of 227 mm Hg at 25 °C(SRC), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1,1-dichloroethane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 59 days(SRC), calculated from its rate constant of 2.74X10-13 cu cm/molecule-sec at 25 °C(3). 1,1-Dichloroethane does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

Aquatic and Atmospheric Fate: Chloroethanes are expected to be present in industrial air and water emissions. They volatilize rapidly from surface water and persist in urban atmospheres. Hydrolysis and biodegradation are expected to be slow. /Chloroethanes/

1,1-Dichloroethane was not detected in 234 table-ready food items from the US FDA's Total Diet Study (10.7 ppb limit of detection)(1). 1,1-Dichloroethane was detected in three peanut butter samples at levels of 1.1, 1.9, and 3.7 g/kg, however, the compound was not found in several other foods that were analyzed(2).

The substance can be absorbed into the body by inhalation and by ingestion.

inhalation, ingestion, skin and/or eye contact

Inhalation (L404) ; oral (L404) ; dermal (L404) ; eye contact (L404)

IDENTIFICATION AND USE: 1,1-Dichloroethane is a colorless, oily liquid. It is used as a chemical intermediate in the production of vinyl chloride and of 1,1,1-trichloroethane. It is also a grain fumigant and has limited use as a solvent for plastics, oils, fats, paint, and varnishes. 1,1-Dichloroethane is used in the manufacture of high vacuum rubber and silicone grease. The chemical can also be used as a coupling agent in antiknock gasoline, for metal degreasing, organic synthesis, and ore floatation. It was formerly used as an anesthetic but it is of no importance in this field today. HUMAN STUDIES: Symptoms of exposure to this compound may include liver and kidney damage, skin and eye irritation, dermatitis, skin burns, unconsciousness, CNS depression, drowsiness, nausea, vomiting, faintness, irritation of the respiratory tract, salivation, sneezing, coughing, dizziness, lacrimation, reddening of the conjunctiva, cyanosis, and circulatory failure. ANIMAL STUDIES: No toxic effects were observed in rabbits dermally exposed to an upper limit dose of 2 mL 1,1-dichloroethane/kg bw for 24 hr during a 14-day observation period. In a study of acute toxicity to adult male rats, there was significant mortality at a concentration of 8.0 g/kg. Intraperitoneal doses of 1000 mg/kg produced no renal necrosis in mice but some evidence of tubular swelling was reported. Urinary protein was increased after injection of 2000 mg/kg and urinary glucose increased after 4000 mg/kg. Rats survived an 8 hr inhalation exposure to 4000 ppm but were killed at 16,000 ppm. Anesthetic effects in mice that inhaled 8,000-10,000 ppm 1,1-dichloroethane for 2 hours were observed, with a minimal lethal dose of 17,300 ppm. Single intraperitoneal injections of 150, 300, 500, and 750 mg 1,1-dichloroethane/kg bw to guinea pigs failed to elicit a change in serum ornithine carbamoyl transferase activity and produced no histological changes in the liver. Pregnant female rats were exposed on days 6 to 15 of gestation to 3800 or 6000 ppm 1,1-dichloroethane vapors, 7 hr/day. No effect occurred in either the dams or fetuses except for slight but statistically significant decreases in food consumption and weight gain by the dams and delayed ossification in the fetuses. No teratological effects were related to exposures. Liver weights of a group of nonpregnant rats were increased by similar exposure, but no histological changes were apparent grossly or microscopically. Chronic 1,1-dichloroethane exposure led to increased incidence of mammary gland adenocarcinomas and hemangiosarcomas in female rats and an increased incidence of hepatocellular carcinomas and benign uterine polyps in mice. 1,1-Dichloroethane has a genotoxic potential as measured by the bone marrow chromosomal aberrations and micronuclei formation tests in mice. Test for cytogenetic effects in cultured Chinese hamster ovary cells indicated that 1,1-dichloroethane induced sister-chromatid exchanges, but did not cause an increase in the number of chromosomal aberrations either with or without metabolic activation. It was not mutagenic in Salmonella/microsome test (Ames test). ECOTOXICITY STUDIES: Effects of a series of chlorinated ethenes and ethanes on hybrid poplar (Populus deltoides x nigra DN34) were assessed in laboratory experiments. Adverse effects were found to increase with increasing number of chlorine atoms within a homologous series of ethenes or ethanes. Ethenes were more toxic than similarly chlorinated ethanes.

U076; As stipulated in 40 CFR 261.33, when 1,1-dichloroethane, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to Federal and/or State hazardous waste regulations. Also defined as a hazardous waste is any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5).

Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. 1,1-Dichloroethane is included on this list. Effective date: 6/1/87; Sunset date: 6/1/97.

Section 8(a) of TSCA requires manufacturers of this chemical substance to report preliminary assessment information concerned with production, exposure, and use to EPA as cited in the preamble in 51 FR 41329. Effective date: 3/11/94; Reporting date: 5/10/94.

Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. 1,1-Dichloroethane is included on this list.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1000 lb or 454 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV.D.3.b).

(CA) CALIFORNIA 5 ug/L

(NJ) NEW JERSEY 50 ug/L

(CT) CONNECTICUT 80 ug/L

(FL) FLORIDA 70 ug/L

(MA) MASSACHUSETTS 70 ug/L

(ME) MAINE 70 ug/L

For more State Drinking Water Guidelines (Complete) data for 1,1-Dichloroethane (7 total), please visit the HSDB record page.

Ethylidene dichloride is primarily used as an intermediate in the manufacture of other chemicals such as vinyl chloride and 1,1,1-trichloroethane, and to manufacture high vacuum rubber. In the past, ethylidene dichloride was used as an anesthetic, but that use has been discontinued.

Used as a chemical intermediate, grain fumigant, and solvent for plastics and oils; in the past, used as an anesthetic; [ACGIH] Used as a cleaning agent, in metal degreasing, rubber cementing, in fabric spreading, ore flotation, fire extinguishing, as an insecticide spray, extraction solvent, coupling agent in antiknock gasoline, paint, varnish, and finish remover, and to make high vacuum rubber; [HSDB] Used as a reagent and solvent for paint and varnishes; [Merck Index]

Metal Degreasing [Category: Clean]

Reagent and chemical intermediate. Solvent for paint, varnishes; degreaser.

1,1-Dichlorethane is used as a chemical intermediate and grain fumigant /SRP: former use/ and has limited use as a solvent for plastics, oils, and fats. It was formerly used as an anesthetic but it is of no importance in this field today.

Used in the manufacture of high vacuum rubber and silicone grease.

2023: 75,000,000 - <150,000,000 lb

NO DATA (1992)

Non-confidential 2012 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: Ethane, 1,1-dichloro-. National Production Volume: 1,000,000 - 10,000,000 lb/yr.

Non-confidential 2016 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: 1,1-Dichloroethane:

Prepared by the action of PCl5 /phosphorus pentachloride/ on acetaldehyde.

1,1-Dichloroethane may ... be obtained by ethane or chloroethane chlorination. This chlorination can be carried out as thermal chlorination, photochlorination, or oxychlorination. These processes, however, are impaired by a lack of selectivity.

... 1,1-Dichloroethane can be produced from acetylene by adding 2 mol of hydrogen chloride. For the first reaction sequence, i.e., the formation of vinyl chloride, mercury catalyst is typically used, although other nonmercuric catalysts are claimed in the literature.

1,1-Dichloroethane via the 1,2-Dichloroethane-Vinyl Chloride Route. Hydrogen chloride and vinyl chloride obtained from 1,2-dichloroethane cracking are reacted in a boiling-bed-type reactor in the presence of a Friedel-Crafts catalyst, preferably ferric chloride (FeCl3).

Acetaldehyde reacts with phosphorus pentachloride to produce 1,1-dichloroethane.

Made from ethylene and chlorine; also from acetylene and hydrogen chloride. /1,2-dichloroethane/

Chemical Classes -> Volatile organic compounds

Food Additives -> EXTRACTION_SOLVENT -> JECFA Functional Classes

All Other Chemical Product and Preparation Manufacturing

Ethane, 1,1-dichloro-: ACTIVE

For the synthesis of 1,1-dichloroethane as an intermediate in the production of 1,1,1-trichloroethane only the vinyl chloride route is important and industrially used.

It occurs, often as an unwanted byproduct, in many chlorination and oxychlorination processes of C2 hydrocarbons.