1,2-Epoxypropan

PO · METHYLOXIRANE · Epoxypropane · 1,2-EPOXYPROPANE · 1,2-PROPYLENE OXIDE · Propylene epoxide · PROPENE OXIDE · Oxirane, 2-Methyl-

https://huagongshe.com/de/chemical/6378

Identifikatoren & physikalische Daten

CAS No.	75-56-9
Summenformel	C3H6O
Durchschnittliche Molmasse	58,08 g/mol
Monoisotopische Masse	58,04186481 g/mol
SMILES	CC1CO1
InChIKey	GOOHAUXETOMSMM-UHFFFAOYSA-N
PubChem CID	6378
ChEMBL	CHEMBL2251584
ChEBI	CHEBI:38685
EC No.	200-879-2
DTXSID	DTXSID5021207
Lokaler Name	1,2-Epoxypropan

Chemische & physikalische Eigenschaften

XLogP	0
Polarare Oberfläche (TPSA)	12,5
H-Brücken-Donoren	0
H-Brücken-Akzeptoren	1
Frei drehbare Bindungen	0
Schwere Atome	4
Formalladung	0
Komplexität	26,5
Stoffklassen	Hazardous Air Pollutants (HAPs)Carcinogens
Kosmetika	Cosmetics ingredient -> Fragrance
Pestizide	Pesticide -> EPA IRISPesticides -> Fumigants
LogP (Verteilungskoeffizient)	log Kow= 0.03.
Geruch	ODOR IS SWEET, ALCOHOLIC, & LIKE ETHER OR BENZENEIn foods, propylene oxide has no residual odor.Ethereal odor... Benzene-like odor ...
Geschmack	In foods, propylene oxide has no residual taste.
Lebensmittelzusatzstoffe	Use unspecified -> FDA Substance added to food
Dichte	0.859 at 32 °F (EPA, 1998) - Less dense than waterwill float0.8304 @ 20/20 °CRelative density (water = 1): 0.830.8304 @ 20°C0.83 g/mL at 25 °C(lit.)
Viscosity	0.28 centipoise at 25 °C0.34 mm²/s at 25 °C
Color/Form	Colorless liquid ... [Note: A gas above 94 degrees F.]
Löslichkeit	greater than or equal to 100 mg/mL at 66 °F (NTP, 1992)Solubility of water in propylene oxide is 12.8% by wt at 20 °C.40.5 wt% water @ 20 °CMISCIBLE WITH ACETONE, BENZENE, CARBON TETRACHLORIDE, METHANOL, & ETHERSoluble in alcohol and ether.In water, 590,000 mg/l @ 25 °C425-450g/l40 g/100 mL (20 ºC)
Corrosivity	NONCORROSIVE TO METALS
Schmelzpunkt	-112 °C
Siedepunkt	34 °C(lit.)
Dampfdichte	2 (vs air)
Dampfdruck	29.43 psi ( 55 °C)
Brechungsindex	n20/D 1.366(lit.)
Flammpunkt	−35 °F
Lagerbedingungen	2-8°C
Aggregatzustand	Liquid
Farbe	Clear
Geruch	Etherealcharacteristicsweet, alcoholyclike natural gas.
Explosionsgrenze	1.9-36%(V)
Spezifische Wärmekapazität	Cp(liquid): 2.07 J/(g·K)Cp(gas): 1.25 J/(g·K), at 25℃
Merck	14,7856
BRN	79763
Henry-Konstante	Not an environmentally important parameter because propylene oxide reacts rapidly with water
Stabilität	Stable. Incompatible with acids, bases, oxidizing agents, copper, copper alloys, brass, bronze, iron, metal chlorides, peroxides and a wide variety of other materials. Reacts with compounds containing labile hydrogen. Extremely flammable - note low boiling point, low flash point and very wide explosion limits. Moisture sensitive.
InChI	1S/C3H6O/c1-3-2-4-3/h3H,2H2,1H3
InChIKey	GOOHAUXETOMSMM-UHFFFAOYSA-N
SMILES	CC1CO1
LogP (Verteilungskoeffizient)	0.030
CAS Datenbank	75-56-9(CAS DataBase Reference)
NIST chemische Informationen	Propylene oxide(75-56-9)
EPA chemische Informationen	Propylene oxide (75-56-9)

Sicherheit & Vorschriften

GHS-Einstufung	DangerH224: Extremely flammable liquid and vapor [Danger Flammable liquids]P203, P210, P233, P240, P241, P242, P243, P261, P262, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P316, P318, P319, P321, P330, P337+P317, P361+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for < 0.1% (1 of 3209) of reports.H224 (99.2%): Extremely flammable liquid and vapor [Danger Flammable liquids]
Regulatorische Informationen	Chemical: Oxirane, methyl-Hazard Traits - CarcinogenicityDermatotoxicityDevelopmental ToxicityGenotoxicityNeurotoxicityOcular ToxicityReproductive ToxicityRespiratory ToxicityOxirane, 2-methyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Oxirane, 2-methyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Propylene oxide is listed in the dataset of EPA Human Health Benchmarks for Pesticides under the Safe Drinking Water Act (40 eCFR 141)Status: Active Update: 26-10-2012 https://echa.europa.eu/registration-dossier/-/registered-dossier/1263Substance: Methyloxirane (Propylene oxide)
Weitere Sicherheitsinformationen	IMAP assessments - Methyloxirane (R-, S- and (R,S)-): Human health tier II assessment
DOT-Kennzeichnung	Flammable Liquid
Brandgefahren	Vapor is heavier than air and may travel considerable distance to source of ignition and flash back. Vapors form explosive mixture with air. If polymerization takes place in container, there may be a violent rupture of container. Explosion hazard is severe when exposed to flame. Violently reacts with acetylide- forming metals such as copper or copper alloys, ammonium hydroxidechlorosulfonic acidhydrochloric acidhydrofluoric acidnitric acidoleum and sulfuric acid. Hazardous polymerization may occur. Avoid active catalytic surfaces such as anhydrous chlorides of iron, tin, and aluminumperoxides of iron and aluminumand alkali metal hydroxides, high temperaturesalkaliesaqueous acidsamines and acidic alcohols. (EPA, 1998)· HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.Extremely flammable. Heating will cause rise in pressure with risk of bursting. Vapour/air mixtures are explosive.
Brandpotenzial	FLAMMABLE, DANGEROUS FIRE RISK
Gesundheitsgefahren	This material is moderately toxic by inhalation and ingestion. It may cause irreversible and reversible changes. Skin contact with the material or solutions of the material cause irritationdiluted solutions are more irritating than undiluted materials. Exposure may cause mild depression of the central nervous system and eye, nasal, and lung irritation. Contact with the liquid can cause blindness and death. Pulmonary edema may recur up to 2 weeks after exposure. (EPA, 1998)· Inhalation or contact with material may irritate or burn skin and eyes.
Gefahrenübersicht	Propylene oxide is used in the production of polyethers (the primary component of polyurethane foams) and propylene glycol. Acute (short-term) exposure of humans and animals to propylene oxide has caused eye and respiratory tract irritation. Dermal contact, even with dilute solutions, has caused skin irritation and necrosis in humans. Propylene oxide is also a mild central nervous system (CNS) depressant in humans. Inflammatory lesions of the nasal cavity, trachea, and lungs and neurological effects have been observed in animals chronically (long-term) exposed to propylene oxide by inhalation. Propylene oxide has been observed to cause tumors at or near the site of administration in rodents, causing forestomach tumors following ingestion via gavage (experimentally placing the chemical in the stomach) and nasal tumors after inhalation exposure. EPA has classified propylene oxide as a Group B2, probable human carcinogen.Liquid causes first degree burns on short exposure. [CHRIS] Allergic contact dermatitis reported in a worker swabbing skin with a disinfectant[Kanerva, p. 1831] Can cause CNS depression and severe eye injuriesA respiratory irritant that may cause pulmonary edema[CAMEO] Causes mild CNS depression in animals after inhalation of high concentrationsA nasal carcinogen in rodents at concentrations causing irritationNOAEL is 50 ppmDetoxified more rapidly than ethylene oxide, and this is one of the reasons for the lower carcinogenic potency of propylene oxideA dermal sensitizer[ACGIH] Propylene oxide (UN1280) has warning of explosive polymerization[ERG 2016]
DOT-Nummer und Handbuch	1280 127P
Reaktive Gruppe	Epoxides
EG-Einstufung	Symbol: F+, TR: 45-46-12-20/21/22-36/37/38S: 53-45Note: E
UN-Einstufung	UN Hazard Class: 3UN Pack Group: I
Special Reports	FLORES GHCHEM ENG PROG 79 (3): 39-43 (1983). REVIEW OF OCCUPATIONAL EXPOSURE TO ALKYLENE OXIDES.Summary Health Assessment Document For 1,2-Propylene Oxide (Draft) (1985) EPA Contract No 68-02-4030.Meylan W et alChemical of Current Interest Propylene Oxide Health and Environmental Effects ProfileToxicol Ind Health 2 (3): 219-60 (1986).DHHS/NTPToxicology & Carcinogenesis Studies of Propylene Oxide in F344/N Rats and B6C3F1 Mice (Inhalation Studies) Technical Report Series No. 267 (1985) NIH Publication No. 85-2527National Toxicology Program. Eleventh Report on Carcinogens (2005). The Report on Carcinogens is an informational scientific and public health document that identifies and discusses substances (including agents, mixtures, or exposure circumstances) that may pose a carcinogenic hazard to human health. 1,2-Propylene Oxide (75-56-9) is listed as reasonably anticipated to be a human carcinogen.[Available from, as of July 31, 2009: http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s155prop.pdf]
Brandbekämpfung	Firefighting should be done from a safe distance or from a protected location. Wear self-contained (positive pressure if available) breathing apparatus and full protective clothing. Isolate for 1/2 mile in all directions if tank car or truck is involved in fire. Move container from area if you can do so without risk. Spray cooling water on containers that are exposed to flames until well after fire is out. For massive fire in cargo area, use unmanned hose holder or monitor nozzlesif this is impossible, withdraw from area and let fire burn. Withdraw immediately in case of rising sound from venting safety device or any discoloration of tank due to fire.Use alcohol-resistant foam, foam, water spray. In case of fire: keep drums, etc., cool by spraying with water.
Erste-Hilfe-Maßnahmen	Fresh air, rest. Seek medical attention if you feel unwell.Remove contaminated clothes. Rinse skin with plenty of water or shower.Rinse with plenty of water (remove contact lenses if easily possible). Refer for medical attention.Rinse mouth. Do NOT induce vomiting. Refer for medical attention if breathing difficulties and/or fever develop.
Freisetungsmaßnahmen	· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.
Erste Hilfe	Signs and Symptoms of Acute Propylene Oxide Exposure: Propylene oxide may irritate or burn the skin, eyes, and respiratory tract. Pulmonary edema may occur up to 2 weeks after exposure. Dermatitis (red, inflamed skin) is common. Other signs and symptoms of acute exposure may include headache, nausea, vomiting, and unconsciousness. Victims may appear as if they are in a drunken stupor.General First Aid:(General first aid procedures)
Sichere Lagerung	Fireproof. Separated from acids, bases and strong oxidants. Dry. Cool. Well closed. Keep in the dark.
Expositionsschutz und Persönliche Schutzausrüstung	· Wear positive pressure self-contained breathing apparatus (SCBA).2.0 [ppm]
Brandbekämpfungsverfahren	If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as a fog. Solid streams of water may be ineffective. Cool all effective containers with flooding quantities of water. Apply water from as far away as possible. Use "alcohol" foam, dry chemical or carbon dioxide.Evacuation: If fire becomes uncontrollable or container is exposed to direct flame, evacuate for a radius of 1 mile.Use flooding quantities of water as fog. May use water spray, dry chemical, "alcohol resistant" foam, or carbon dioxide. Use water spray to keep fire exposed containers cool. Fight fire from protected location or maximum possible distance.
Lagerbedingungen	Use glass or metal containers sealed with nitrogen.PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/Store in a cool, dry, well-ventilated location. Outside or detached storage is preferred. Separate from acids, alkalies, salts, combustible material, clay-based absorbents.
Reinigungsverfahren	Evacuation: If material leaking (not on fire) consider evacuation from downwind area based on amount of material spilled, location and weather conditions.1. REMOVE ALL IGNITION SOURCES. 2. VENTILATE AREA OF SPILL OR LEAK. 3. FOR SMALL QUANTITIES, ABSORB ON PAPER TOWELS. EVAPORATE IN A SAFE PLACE (SUCH AS A FUME HOOD). ALLOW SUFFICIENT TIME FOR EVAPORATING VAPORS TO COMPLETELY CLEAR THE HOOD DUCTWORK. BURN THE PAPER IN A SUITABLE LOCATION AWAY FROM COMBUSTIBLE MATERIALS. LARGE QUANTITIES MAY BE COLLECTED, DISSOLVED IN ALC OF GREATER MOL WT THAN BUTYL ALC, & ATOMIZED IN A SUITABLE COMBUSTION CHAMBER.Land spill: Dig a pit, pond, lagoon, or holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash, cement powder, sawdust, or commercial sorbents. Apply "universal" gelling agent to immobilize spill.Water spill: Use natural barriers or oil spill control booms to limit spill. Use surface active agent (eg detergent, soaps, alcohols) to compress and thicken spilled material. Inject "universal" gelling agent to solidify encircled spill and increase effectiveness of booms. If dissolved, apply activated carbon at ten times the spilled amount in region of 10 ppm or greater concentration. Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates.For more Cleanup Methods (Complete) data for 1,2-PROPYLENE OXIDE (7 total), please visit the HSDB record page.
Freisetung ohne Brand	Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)polymerization hazard]:
Entsorgungsverfahren	SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.Propylene oxide is a waste chemical stream constituent which may be subjected to ultimate disposal by controlled incineration. Concentrated waste containing no peroxidesdischarge liquid at a controlled rate near a pilot flame. Concentrated waste containing peroxidesperforation of a container of waste from a safe distance followed by open burning.PROPYLENE OXIDE MAY BE DISPOSED OF BY DISSOLVING IN PENTYL OR HIGHER CARBON NUMBER ALC & ATOMIZING IN A SUITABLE COMBUSTION CHAMBER.Concentrated waste containing no peroxides-discharge liquid at a controlled rate near a pilot flame. Concentrated waste containing peroxides-perforation of a container of the waste from a safe distance followed by open burning. Recommendable methods: Incineration, open burning & evaporation. Peer review: Very volatile (bp 33 °C) may make it difficult to feed to incinerator with safety. Open burning and evaporation are recommendable for small amounts. (Peer-review conclusions of an IRPTC expert consultation (May 1985))For more Disposal Methods (Complete) data for 1,2-PROPYLENE OXIDE (9 total), please visit the HSDB record page.
Verschüttetes entsorgen	Evacuate danger area! Consult an expert! Remove all ignition sources. Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Collect leaking liquid in sealable dry containers. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations.
Cancer Sites	Gastrointestinal[in animals: nasal tumors]
Wechselwirkungen	WHEN ... /IT IS MIXED WITH CARBON DIOXIDE/ SMALL DOSES ARE MORE EFFECTIVE & A QUICKER KILL IS EFFECTED THROUGH STIMULATION OF INSECT RESP.
Zielorgane	RespiratoryEyes, skin, respiratory system
Ökotoxizitätswerte	LC50 Goldfish 170 mg/l/24 hr /Conditions of bioassay not specified/LC50 Mullet 89 ppm/96 hr /Conditions of bioassay not specified/TLm Gambusia affinis (mosquito fish) 141 mg/l/96 hr at 24 °C, static bioassay.TLm Bluegill 215 mg/l/96 hr at 24 °C, static bioassasy.
Umweltverhalten	TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 25(SRC), determined from an measured log Kow of 0.03(2) and a regression-derived equation(3), indicates that 1,2-propylene oxide is expected to have very high mobility in soil(SRC). Volatilization of 1,2-propylene oxide from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 6.96X10-5 atm-cu m/mole(SRC), calculated from its vapor pressure, 538 mm Hg(4), and water solubility, 5.9X10+5 mg/l(5). The potential for volatilization of 1,2-propylene oxide from dry soil surfaces may exist (SRC) based upon a vapor pressure of 538 mm Hg(4). The aqueous hydrolysis of propylene oxide occurs at an environmentally important ratetherefore, hydrolysis in moist soil is likely to be important (5). 1,2-Propylene oxide, present at 100 mg/l, reached 95% of its theoretical BOD in 3 weeks using an activated sludge inoculum at 30 mg/l and the Japanese MITI test(6), suggesting biodegradation will be an important fate process(SRC).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 25(SRC), determined from an measured log Kow of 0.03 and a regression-derived equation(3), indicates that 1,2-propylene oxide is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 6.96X10-5 atm-cu m/mole (SRC), based upon its vapor pressure, 538 mm Hg(4), and water solubility, 5.9X10+5 mg/l(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 12 hours and 6 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 3(SRC), from its log Kow(2) and a regression- derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). In freshwater, propylene oxide will hydrolyze with estimated half-lives of 11.6 days (pH's 7-9) and 6.6 days (pH 5) at 25 °C(5). 1,2-Propylene oxide, present at 100 mg/l, reached 95% of its theoretical BOD in 3 weeks using an activated sludge inoculum at 30 mg/l and the Japanese MITI test(8), suggesting biodegradation will be an important fate process(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1,2-propylene oxide, which has a vapor pressure of 538 mm Hg at 25 °C(2) is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1,2-propylene oxide is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 30 days(SRC), calculated from its rate constant of 5.2X10-12 cu cm/molecule-sec at 25 °C(3).
Lebensmitteluntersuchungswerte	TREATED WHEAT HAD EPOXIDE RESIDUE OF 300 PPM, BUT AFTER IT WAS MILLED FLOUR CONTAINED LESS. /PROPYLENE OXIDE/WHEN FOODS WERE TREATED WITH PROPYLENE OXIDE, 1-CHLOR-2-PROPANOL WAS FORMED.
Unerwünschte Wirkungen	Neurotoxin - Other CNS neurotoxin
Expositionspfade	The substance can be absorbed into the body by inhalation, through the skin and by ingestion.inhalation, ingestion, skin and/or eye contact
Signs and Symptoms	Cough. Sore throat.Redness.Redness. Pain.irritation eyes, skin, respiratory systemskin blisters, burns[potential occupational carcinogen]
Ongoing Test Status	The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. [http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=75-56-9]
Effluent Concentrations	A propylene oxide concentration of 0.047 mg/l was detected in a water effluent from Olin Corporation's Brandenberg, KY chemical production facility on Feb 2, 1974(1). Atmospheric emissions of propylene oxide from propylene oxide manufacturing processes during 1978 were estimated to be about 1.16 million lb(2). Atmospheric emissions resulting from the use of propylene oxide in the production of urethane polyols, propylene glycol, surfactant polyols, di- and tripropylene glycols, glycol ethers and miscellaneous applications during 1978 were estimated to be about 147.7, 13.9, 15.8, 2.9, 1.2 and 3.8 thousand lb, respectively(2). It has been suggested that proplyene oxide may be emitted to the atmosphere from automobile exhaust and from combustion exhausts of stationary sources that burn hydrocarbons(3).
EPA IRIS Information	Propylene oxideGastrointestinalRespiratory3 x 10 ^-2 mg/m^3
TSCA-Anforderungen	Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Oxirane, methyl is included on this list.
FIFRA-Anforderungen	As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA, as amended in 1988, were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern and List D pesticides of less concern. Propylene oxide is found on List B. Case No: 2560Case Status: OPP is reviewing data from the pesticide's producers regarding its human health and/or environmental effects, or OPP is determining the pesticide's eligibility for reregistration and developing the Reregistration Eligibility Decision (RED) document.Active ingredient (AI): Propylene oxideAI Status: The producers of the pesticide has made commitments to conduct the studies and pay the fees required for reregistration, and are meeting those commitments in a timely manner.
Luftstandards	This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Propylene oxide is produced, as an intermediate or a final product, by process units covered under this subpart.Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. 1,2-Propylene oxide is included on this list.
CERCLA-Meldepflichtmengen	Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 100 lb or 45.4 kg. The toll free number of the NRC is (800) 424-8802In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Propylene oxide is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 10,000 lbs. Extremely hazardous substances that are solids are subject to either of two threshold planning quantities ... The lower quantity applies only if the solid exists in powdered for and has a particle size less than 100 micronsor is handled in solution or in molten formor meets the criteria for a National Fire Protection Association (NFPA) rating of 2, 3 or 4 for reactivity. If the solid does not meet any of these criteria, it is subject to the upper ... threshold planning quantity ... .
Clean Water Act Anforderungen	Propylene oxide is designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes any isomers and hydrates, as well as any solutions and mixtures containing this substance.
DHS Chemicals of Interest (COI)	Propylene oxide110000Flammable chemical that can be released at a facility.
Landesrichtlinien für Trinkwasser	(FL) FLORIDA 5,000 ug/l
Wassergefährdungsklasse (WGK)	3
Sofort lebensgefährliche Konzentration	400 ppm
TSCA-Inventar-Status	TSCA listed
UN-Transportnummer	UN 1280
Zollcode	2910 20 00
RTECS-Nr.	TZ2975000
R-Sätze (R)	45-46-12-20/21/22-36/37/38
Toxizität	LD50 orally in rats: 1.14 g/kg (Smyth)
Gefahrensymbole	F+,T
Sicherheitshinweise (S)	53-45
Gefahrenklasse	3Acute Tox. 3 DermalAcute Tox. 3 InhalationAcute Tox. 4 OralCarc. 1BEye Irrit. 2Flam. Liq. 1Muta. 1BSTOT SE 3
Verpackungsgruppe	I
Lagerklasse	3 - Flammable liquids
Gefahrstoffdaten	75-56-9(Hazardous Substances Data)
Selbstentzündungstemperatur	430 °C

Anwendungen & Verwendung

Beschreibung

Propylene oxide is an allergic and irritant agent, used as a solvent and raw material in the chemical industry as starting material and intermediate for a broad spectrum of polymers.

Verwenden

Propylene oxide is used as a fumigant forfoodstuffs; as a stabilizer for fuels, heat-ing oils, and chlorinated hydrocarbons; asa fuel–air explosive in munitions; and toenhance the decay resistance of wood andparticleboard (Mallari et al. 1989). Recentstudies indicate that the fumigant potentialof propylene oxide enhances at a low pres-sure of 100 mm Hg which could render it asan alternative to methyl bromide for rapiddisinfection of commodities (Isikber et al.2004).