Retinylacetat
Retinol, acetate
Grundinformationen
- CAS
127-47-9- Standard-SMILES
CC(=O)OC/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C- InChIKey
QGNJRVVDBSJHIZ-QHLGVNSISA-N- Summenformel
- C22H32O2
- Durchschnittliche Molmasse
- 328,5 g/mol
- Monoisotopische Masse
- 328,24023026
Überblick
Retinyl acetate is an acetate ester. It is functionally related to an all-trans-retinol.
Namen und Bezeichner
- Bevorzugter Name
- Retinol, acetate
- IUPAC
- [(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] acetate
- Lokaler Name
- Retinylacetat
- Englischer Name
- Retinyl acetate
- Summenformel
- C22H32O2
- Molmasse
- 328.49
Namen und Synonyme
RETINYL ACETATEVitamin A acetateRetinol acetate127-47-9Retinol, acetateVitamin A1 acetateall-trans-Retinol acetateCrystaletsVitamin A alcohol acetateDavitan A 650all-trans-Vitamin A acetateRetinol, acetate, all-trans-
Weitere Namen anzeigen
retinylVITAMIN A ACETATALL-TRANS-RETINYL ACETATERetinylacetatRETINOL ACETATE ALL TRANSMyvakMyvax
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-yl acetateall-trans-RetinylacetateAcetic acid, retinyl ester[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] acetateDTXSID60212403LE3D9D6OYVitamin A, acetateVitamin A acetate (tritiated)
Datenbank-Bezeichner
- CAS
127-47-9、64536-04-5- PubChem CID
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 6,3
- Polarare Oberfläche (TPSA)
- 26,3 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 2
- Frei drehbare Bindungen
- 7
- Schwere Atome
- 24
- Formalladung
- 0
- Komplexität
- 595
Experimentelle und physikochemische Eigenschaften
LipidsLipids -> Prenol Lipids [PR] -> Isoprenoids [PR01] -> Retinoids [PR0109]
CosmeticsSkin conditioning
SpringerMaterials PropertiesChemical diffusion
Food AdditivesNUTRIENT SUPPLEMENT -> FDA Substance added to food
Physikochemische Eigenschaften
- Schmelzpunkt
- 57 · 57-58 °C
- Siedepunkt
- 406.22 °C · 406.22°C (rough estimate)
- Dichte
- 1.0474 · 1.0474 (rough estimate)
- Brechungsindex
- 1.547 · 1.547-1.555
- Flammpunkt
- 14 ℃ · 14℃
- storage temp.
- 2 · 2-8°C
- Löslichkeit
- 25 mg/mL · absolute ethanol: 25 mg/mL
- Aggregatzustand
- solid or viscous liquid
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
This chemical does not meet GHS hazard criteria for 0.3% (1 of 374) of reports.
Danger
H315 (83.4%): Causes skin irritation [Warning Skin corrosion/irritation]
P203, P264, P273, P280, P302+P352, P318, P321, P332+P317, P362+P364, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 374 reports by companies from 22 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Regulatory Information
Chemical: Retinol, acetate
Regulation (EC) No 1831/2003 (amended)
REACH registered substance: Retinyl acetate (EC: 204-844-2)
Retinol acetate: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and CategoriesSkin Irrit. 2 (83.4%)
Toxikologische Informationen
Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).
Sicherheitsdaten
- F
- 1-8-10
- wgk
- 2
- tsca
- TSCA listed
- ridadr
- UN1170 - class 3 - PG 2 - Ethanol
- hs_code
- 29362100
- RTECS-Nr.
- VH6825000
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved.
Verwendung und Herstellung
Household ProductsInformation on 4 consumer products that contain Retinyl acetate in the following categories is provided:
Use ClassificationCosmetics -> Skin conditioning
General Manufacturing InformationRetinol, acetate: ACTIVE
Anwendungen
BeschreibungRetinyl acetate (retinol acetate, vitamin A acetate,127-47-9) is a natural form of vitamin A. It is the acetate ester of retinol. It consists of yellow crystals which are greasy or sticky. It has a mild, characteristic odor. It has potential antineoplastic and chemo-preventive activities. It can be used to fortify food with vitamin A. As vitamin A acetate can induce cell differentiation and inhibit cell proliferation, it is used in skin-conditioning agent.
VerwendenRetinyl acetate has been used: a control diet to study its effect at different developmental periods in fish larvae to study its inhibitory effects on Mycobacterium aviumsubspeciesparatuberculosis(MAP) strains as an internal standard in high performance liquid chromatography (HPLC) to quantify vitamin A in fortified milk
Zugehörige Reaktionen
6
Notizen zur Verbindung
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