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HCID 6383Erstellt: 27. Oktober 2026

Bromotrichloromethane

https://huagongshe.com/de/chemical/6383

Molekülstruktur von Bromotrichloromethane

Identifikatoren & physikalische Daten

CAS No.75-62-7
SummenformelCBrCl3
Durchschnittliche Molmasse198,27 g/mol
Monoisotopische Masse195,8249 g/mol
SMILESClC(Cl)(Cl)Br
InChIKeyXNNQFQFUQLJSQT-UHFFFAOYSA-N
PubChem CID6383
ChEMBLCHEMBL160802
EC No.200-886-0
DTXSIDDTXSID7023930

Chemische & physikalische Eigenschaften

XLogP2,9
Polarare Oberfläche (TPSA)0
H-Brücken-Donoren0
H-Brücken-Akzeptoren0
Frei drehbare Bindungen0
Schwere Atome5
Formalladung0
Komplexität28
GeruchCHLOROFORM-LIKE ODOR
Dichte2.012 @ 25 °C2.012 @25 °C2.012 g/cm3(Temp: 25 °C)
Viscosity3.29X10-3 Pa.s @ -21 °C
Color/FormCOLORLESS HEAVY LIQUID
LöslichkeitINSOL IN WATERSOL IN ALL PROP IN ALCOHOL & ETHERMISCIBLE WITH MANY ORG LIQUIDSVery soluble in ether and ethanol
Siedepunkt105 °C104.2 °C @760 [mm Hg]
DecompositionWhen heated to decomposition it emits very toxic fumes of /hydrogen chloride/ and /hydrogen bromide/.
Schmelzpunkt-5.7 °C
Dampfdruck39.0 [mmHg]39 mm Hg at 25 °C39 [mm Hg] @25 °C
Surface Tension4.24X10-2 N/m @ -21 °C
BrechungsindexMAX ABSORPTION (ISOOCTANE): 240 NM (LOG E= 2.3)INDEX OF REFRACTION: 1.5065 @ 20 °C/DIndex of refraction = 1.5065 @ 20 °C/D
Heat of Vaporization3.77X10+7 J/kmol @ -21 °C

Sicherheit & Vorschriften

GHS-EinstufungWarningH302 (79.5%): Harmful if swallowed [Warning Acute toxicity, oral]H312 (22.6%): Harmful in contact with skin [Warning Acute toxicity, dermal]H315 (80%): Causes skin irritation [Warning Skin corrosion/irritation]H319 (80%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]H332 (20.5%): Harmful if inhaled [Warning Acute toxicity, inhalation]H335 (22.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposureRespiratory tract irritation]P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 190 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
Regulatorische InformationenChemical: Methane, bromotrichloro-Status: Active Update: 24-03-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/20283Bromotrichloromethane: Does not have an individual approval but may be used under an appropriate group standard
GefahrenübersichtIntraperitoneal LD50 (rat) = 119 mg/kgCauses CNS depression[ChemIDplus] Causes liver injury in animal studies[HSDB]
Hazard Classes and CategoriesAcute Tox. 4 (79.5%)Acute Tox. 4 (22.6%)Skin Irrit. 2 (80%)Eye Irrit. 2A (80%)Acute Tox. 4 (20.5%)STOT SE 3 (22.6%)
Critical Temperature and PressureCritical temperature: 333 °Ccritical pressure: 49 atm
Hazardous Reactivities and IncompatibilitiesDURING UNCATALYZED ADDITION OF BROMOTRICHLOROMETHANE TO ETHYLENE VIOLENT EXPLOSION OCCURRED.
EntsorgungsverfahrenSRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
Protective Action Criteria (PAC)0.71 [mg/m3]7.9 [mg/m3]47 [mg/m3]
WechselwirkungenHEPATOCYTES FROM LIVERS OF RATS FED A SEMISYNTHETIC VITAMIN E-SUPPLEMENTED DIET WERE SLIGHTLY MORE PROTECTED FROM PEROXIDATION AND CELLULAR DAMAGE INDUCED BY BROMOTRICHLOROMETHANE TREATMENT THAN WERE HEPATOCYTES FROM RATS FED A VITAMIN E-DEFICIENT DIET.WHEN INCUBATED FOR 15 MIN IN AIR WITH RAT LIVER MICROSOMES FROM PHENOBARBITAL-TREATED RATS, A NADPH-GENERATING SYSTEM, AND GSH (5 MILLIMOLAR), BROMOTRICHLOROMETHANE WAS CONVERTED TO DIGLUTATHIONYL DITHIOCARBONATE.WHEN ISOLATED RAT HEPATOCYTES WERE INCUBATED WITH 2 MILLIMOLAR BROMOTRICHLOROMETHANE, INCR IN THE NUMBER OF CELLS TAKING UP TRYPAN BLUE, RELEASING LACTATE DEHYDROGENASE OR FORMING MALONDIALDEHYDE WAS OFFSET BY ADDING 1X10-4 MOLAR 2-HYDROXYESTRADIOL OR (+)-CYANIDANOL-3.PROTECTIVE EFFECTS OF CADMIUM ACETATE IN TRICHLOROBROMOMETHANE POISONING.For more Interactions (Complete) data for BROMOTRICHLOROMETHANE (6 total), please visit the HSDB record page.
UmweltverhaltenTERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 567(SRC), determined from an estimated log Kow(2,SRC) and a regression-derived equation(3), indicates that bromotrichloromethane is expected to have low mobility in soil(SRC). Volatilization of bromotrichloromethane from moist soil surfaces is expected (SRC) given an estimated Henry's Law constant of 3.7X10-4 atm-cu m/mole(SRC), using a fragment constant estimation method(4). The potential for volatilization of bromotrichloromethane from dry soil surfaces may exist(SRC) based on a measured vapor pressure of 39 mm Hg(5). Based upon the highly halogenated structure of bromotrichloromethane, biodegradation in soil is expected to be slow(6,SRC).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 567(SRC), determined from an estimated log Kow of 2.5(2,SRC) and a regression-derived equation(3), indicates that bromotrichloromethane is expected to adsorb to suspended solids and sediment in water(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 3.7X10-4 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 3.7 hrs and 6.6 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 49(SRC), from an estimated log Kow(2) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is moderate. Based upon the highly halogenated structure of bromotrichloromethane, biodegradation in water is expected to be slow(7).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), bromotrichloromethane, which has a measured vapor pressure of 39 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Based on bromotrichloromethane's structural similarity to bromotrifluoromethane, it is expected to slowly degrade in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for bromotrichloromethane's reaction in air is estimated to be greater than 44 years(3), based on bromotrifluoromethane's rate constant of <5.0X10-16 cu cm/molecule-sec at 25 °C(3). Photolysis may occur based on bromotrichloromethane's structural similarity to other halogenated methane compounds but not at an environmentally important rate(4).
LebensmitteluntersuchungswerteBromotrichloromethane was identified as a volatile compound from bacon(1). Bromotrichloromethane was identified as a meat volatile from pork(2).
Unerwünschte WirkungenNeurotoxin - Acute solvent syndromeOccupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
Milk ConcentrationsTrace amounts of bromotrichloromethane were identified in pasteurized milk(1).
EPA IRIS InformationBromotrichloromethane
Soil Adsorption/MobilityThe Koc of bromotrichloromethane is estimated as approximately 567(SRC), using an estimated log Kow of 2.5(1,SRC) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that bromotrichloromethane is expected to have low mobility in soil(SRC).
Natural Pollution SourcesBromotrichloromethane has been identified as a volatile compound in both bacon(1) and pork(2).
Human Toxicity ExcerptsToxic by ingestion and inhalation of fumes.
Artificial Pollution SourcesBromotrichloromethane's production and use in organic syntheses(1) may result in its release to the environment(SRC).
Environmental BiodegradationBiodehalogenation of bromotrichloromethane by hydrogenolysis occurred in cultures with Pseudomonas putida(1). Based upon the highly halogenated structure of bromotrichloromethane, biodegradation is expected to be slow(2).
Environmental BioconcentrationAn estimated BCF value of 49 was calculated for bromotrichloromethane(SRC), using an estimated log Kow of 2.5(1,SRC) and a regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is moderate(SRC).
AlarmwortWarnung
GefahrenhinweiseCode Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H302