| GHS-Einstufung | DangerH302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]H312 (18.8%): Harmful in contact with skin [Warning Acute toxicity, dermal]H314 (18.4%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]H315 (81.6%): Causes skin irritation [Warning Skin corrosion/irritation]H319 (81.2%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]H332 (18.4%): Harmful if inhaled [Warning Acute toxicity, inhalation]P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P321, P330, P332+P317, P337+P317, P362+P364, P363, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 256 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
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| Regulatorische Informationen | Chemical: Propanoic acid, 2,2-dimethyl-Propanoic acid, 2,2-dimethyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Propanoic acid, 2,2-dimethyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 13-06-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/18932Status: Active Update: 02-02-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/1887Pivalic acid: Does not have an individual approval but may be used under an appropriate group standard |
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| DOT-Kennzeichnung | Corrosive |
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| Brandgefahren | COMBUSTIBLE. Produces vapors irritating to eyes and skin. Decomposes to produce acrid smoke and fumes. (USCG, 1999)Combustible. Above 64 °C explosive vapour/air mixtures may be formed. |
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| Brandpotenzial | Combustible. |
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| Gesundheitsgefahren | CALL FOR MEDICAL AID. SOLID: Irritating to eyes and skin. Harmful if swallowed. IF IN EYES OR ON SKIN, flush with running water for at least 15 minuteshold eyelids open if necessary. Wash skin with soap and water. Remove and isolate contaminated clothing and shoes at the site. If SWALLOWED and victim is UNCONSCIOUS OR HAVING CONVULSIONS, do nothing except keep victim warm. Because of low volatility, it is relatively harmless when inhaled at normal ambient temperature (around 20 °C). It is slightly toxic by ingestion or skin absorption. The vapor is irritating at elevated temperatures. Can cause considerable discomfort by oral routesmay cause reversible or irreversible changes to exposed tissue, not permanent injury or death. (USCG, 1999) |
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| Gefahrenübersicht | A skin, eye, and respiratory tract irritant[ICSC] In lethal-dose inhalation studies, causes somnolence in mice and dyspnea in rats[RTECS] A corrosive substance that can cause injury to the skin and eyes[CHEMINFO] A corrosive substance that can cause injury to the skin, eyes, and respiratory tractInhalation may cause chemical pneumonitisCan be absorbed through skin[MSDSonline] |
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| Reaktive Gruppe | Acids, Carboxylic |
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| UN-Einstufung | UN Hazard Class: 8UN Pack Group: II |
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| Special Reports | EPA/Office of Pollution Prevention and ToxicsHigh Production Volume (HPV) Challenge Program's Robust Summaries and Test Plans. Available from the Database Query page at: http://www.epa.gov/hpv/pubs/hpvrstp.htm on Neoacids C5-C28 Category as of January 3, 2008.European Chemicals BureauIUCLID Dataset, Pivalic acid (75-98-9) (2000 CD-ROM edition). Available from the Database Query page at: http://ecb.jrc.it/esis/esis.php as of January 3, 2008. |
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| Reactivity Profile | TRIMETHYLACETIC ACID is a carboxylic acid. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in waterthose with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in it to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless g |
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| Luftstandards | This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Neopentanoic acid is produced, as an intermediate or a final product, by process units covered under this subpart. |
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| Chemical Dangers | The solution in water is a weak acid. Reacts with bases and strong oxidants. This generates fire and explosion hazard. Attacks many metals. This produces flammable/explosive gas (hydrogen - see ICSC 0001). |
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| Brandbekämpfung | Extingiush small fires: dry chemical, CO2, water spray or foamlarge fires: water spray, fog or foam. (USCG, 1999)Use water spray, powder, alcohol-resistant foam, carbon dioxide. |
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| Erste-Hilfe-Maßnahmen | Fresh air, rest. Refer for medical attention.Rinse skin with plenty of water or shower. Refer for medical attention if skin irritation occurs.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. |
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| Erste Hilfe | INHALATION: Remove victim to fresh air, get medical attention if irrtation persists.EYES: Hold eyelids open and flush with plenty of water for at least 15 minutes and get medical attention.SKIN: Contaminated skin should be washed with soap and water. (USCG, 1999) |
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| Sichere Lagerung | Separated from strong oxidants, bases and food and feedstuffs. Dry. Well closed. Ventilation along the floor. |
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| Brandbekämpfungsverfahren | Powder, alcohol-resistant foam, water spray, carbon dioxide.If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical, or carbon dioxide. |
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| Lagerbedingungen | Separated from strong oxidants, food and feedstuffs. |
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| Reinigungsverfahren | Collect leaking liquid in sealable containers. If solid: sweep spilled substance into containersif appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water. (Extra personal protection: A/P2 filter respirator for organic vapour and harmful dust).Environmental considerations: Land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash, cement powder, or commercial sorbents /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./Environmental considerations: Water spill: Use natural barriers or oil spill control booms to limit spill travel. Remove trapped material with suction hoses.Environmental considerations: Air spill: Apply water spray or mist to knock down vapors. |
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| Freisetung ohne Brand | Avoid contact with solid and dust. Keep people away. Wear self-contained positive pressure breathing apparatus and full protective clothing. Stop discharge if possible. Shut off ignition sources. Call fire department. Isolate and remove discharged material. Notify local health and pollution control agencies. Issue warning - water contaminant Should be removed. Chemical and physical treatment. Dangerous to aquatic life in high concentrations. May be dangerous if it enter water intakes. Notify local health and wildlife officials. Notify operators of nearby water intakes. (USCG, 1999) |
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| Entsorgungsverfahren | SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices. |
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| Verschüttetes entsorgen | Personal protection: filter respirator for organic gases and particulates adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb liquid in sand or inert absorbent. If solid: sweep spilled substance into containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water. Store and dispose of according to local regulations. |
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| Preventive Measures | If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Use water spray to disperse vapors and dilute standing pools of liquid..Personnel protection: Avoid breathing vapors. Keep upwind. ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water.SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place. |
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| Isolation and Evacuation | Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directionsalso, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024) |
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| Ökotoxizitätswerte | LC50Species: Carassius auratus (Goldfish, weight 3.3 g)Conditions: freshwater, static, 20 °C, pH 5.4, dissolved oxygen >4.0 mg/LConcentration: 400000 ug/L for 24 hrConditions: freshwater, static, 20 °C, pH 7.0, dissolved oxygen >4.0 mg/LConcentration: 4500000 ug/L for 24 hrConcentration: 380000 ug/L for 96 hrEC50Species: Xenopus laevis (African clawed frog, embryo)Conditions: freshwater, renewal, pH 7.0-7.8Concentration: 2669400 ug/L for 96 hr (2513000-2835000 ug/L)Effect: general developmental changes /> or =98% purity/For more Ecotoxicity Values (Complete) data for 2,2-DIMETHYLPROPANOIC ACID (8 total), please visit the HSDB record page. |
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| Umweltverhalten | TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 150(SRC), determined from a log Kow of 1.48(2) and a regression-derived equation(3), indicates that 2,2-dimethylpropanoic acid is expected to have high mobility in soil(SRC). The pKa of 2,2-dimethylpropanoic acid is 5.03(4), indicating that this compound will exist partially in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5). Volatilization of 2,2-dimethylpropanoic acid from moist soil surfaces is not expected to be an important fate process because anions do not volatilize. 2,2-Dimethylpropanoic acid is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.50 mm Hg(6). Several screening studies(7-11) suggest that under aerobic conditions, 2,2-dimethylpropanoic acid may biodegrade in soil with sufficient acclimation time, but no rate data were available.AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 150(SRC), determined from a log Kow of 1.48(2) and a regression-derived equation(3), indicates that 2,2-dimethylpropanoic acid is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 2.78X10-6 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 13 and 100 days, respectively(SRC). According to a classification scheme(5), BCFs of <0.2-1.2 at a concentration of 1 ppb and <2.3 at a concentration of 0.1 ppb(6), suggest bioconcentration in aquatic organisms is low(SRC). Several screening studies(7-11) suggest that under aerobic conditions, 2,2-dimethylpropanoic acid may biodegrade in aquatic systems with sufficient acclimation time but no data were available. Aquatic oxidation with hydroxyl radicals is not likely to be an important fate process based on a half-life of 1.5 yrs in water under continuous sunlight(12).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2,2-dimethylpropanoic acid, which has a vapor pressure of 0.50 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 2,2-dimethylpropanoic acid is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 27 days(SRC), calculated from its rate constant of 5.9X10-13 cu cm/molecule-sec at 25 °C(3). |
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| Unerwünschte Wirkungen | Dermatotoxin - Skin burns.Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors. |
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| Expositionspfade | The substance can be absorbed into the body by inhalation, through the skin and by ingestion. |
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| Signs and Symptoms | Cough. Sore throat.Redness. Pain.Burning sensation. |
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| Effluent Concentrations | 2,2-Dimethylpropanoic acid was identified at a concn of 8 ppm in effluent from one of three New Jersey publicly owned treatment works (POTWs) located in an industrial area of the state(1). |
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| Soil Adsorption/Mobility | The Koc of 2,2-dimethylpropanoic acid is estimated as 150(SRC), using a log Kow of 1.48(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 2,2-dimethylpropanoic acid is expected to have high mobility in soil. The pKa of 2,2-dimethylpropanoic acid is 5.03(4), indicating that this compound will exist partially in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5). |
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| Human Toxicity Excerpts | /HUMAN EXPOSURE STUDIES/ Treatment with pivalic acid containing prodrugs has been shown to cause carnitine depletion by loss of pivaloyl carnitine in urine. A 7-day standard pivmecillinam treatment of adults lead to a marked decrease of the free serum carnitine concentration (44.6 to 12.9 umol/L), whereas no change was seen in those given norfloxacine (40.0 to 40.5 umol/L). In some patients irrespective of age the free serum carnitine concentration was decreased to levels (around 10 umol/L) at which an impaired ketone-body production may occur./HUMAN EXPOSURE STUDIES/ Short-term administration of pivampicillin and pivmecillinam resulted in a reduction of serum carnitine concentration and an increase in excretion of acylcarnitine in urine. These changes persisted for more than ten days after cessation of therapy. In seven girls on long-term treatment with a mixture of pivampicillin and pivmecillinam the mean total serum carnitine concentration fell to 15% (7-27%) of pretreatment values. The acylcarnitine fraction was 11-57% of total carnitine, compared with less than 2% before treatment. Muscle carnitine concentrations in two girls treated with the antibiotics for 22 and 30 months were only 10% of the mean reference value. These concentrations in serum and muscle are in the range encountered in patients with carnitine deficiencies of other aetiologies in which life-threatening metabolic crises may arise. The risk of adverse effects from prodrugs that give rise to pivalic acid should be seriously considered, particularly in patients under metabolic stress./CASE REPORTS/ An 18-month-old boy was treated with an antibiotic containing pivalic acid for 6 months for intractable otitis media and then developed repeated convulsions and loss of consciousness. Laboratory data showed hypoglycemia and hypocarnitinemia. Intravenous administration of glucose was ineffective against the seizures and loss of consciousness. However, the patient regained consciousness and recovered soon after intravenous infusion of carnitine. To our knowledge, intravenous carnitine administration that contributed to marked improvements in neurologic deficit caused by administration of an antibiotic containing pivalic acid has not been reported previously. |
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| Artificial Pollution Sources | 2,2-Dimethylpropanoic acid's production and use in the production of polymers and resins, pharmaceuticals, agricultural chemicals, cosmetics, fuels, lubricants and transmission fluids(1) may result in its release to the environment through various waste streams(SRC). |
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| Environmental Biodegradation | AEROBIC: 2,2-Dimethylpropanoic acid at a high initial concn of 100 ppm exhibited a 24% theoratical BOD over an incubation period of 5 days in an aerobic screening study at 21 °C using sewage inoculum(1). An aerobic screening study using activated sludge inoculum at pH 7 showed only a small removal of 2,2-dimethylpropanoic acid (high initial concn of 500 ppm) in a Warburg respirometer at pH 7(5). 2,2-Dimethylpropanoic acid exhibited a 10% theoratical BOD over an incubation period of 5 days in an aerobic screening study at 20 °C using sewage inoculum(2). 2,2-Dimethylpropanoic acid at an initial concn of 3.4 ppm exhibited a 52% theoretical BOD over an incubation period of 10 days in an aerobic screening study at 25 °C and pH 6.5-7.5 using sewage inoculum(3). 2,2-Dimethylpropanoic acid at an initial concn of 4.1 ppm exhibited 1.2, 0, 14, and 86% theoretical BOD over respective incubation periods of 2, 5, 10, and 20 days in an aerobic screening study at 25 °C using soil inoculum(4). |
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| Environmental Bioconcentration | The BCF of 2,2-dimethylpropanoic acid was <0.2-1.2 at a concentration of 1 ppb and <2.3 at a concentration of 0.1 ppb using carp (Cypinus carpio) which were exposed over a 6-week period(1). According to a classification scheme(2), these BCFs suggest bioconcentration in aquatic organisms is low(SRC). |
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| Volatilization from Water/Soil | The Henry's Law constant for 2,2-dimethylpropanoic acid is 2.78X10-6 atm-cu m/mole(1). This Henry's Law constant indicates that 2,2-dimethylpropanoic acid is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 13 days(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 100 days. 2,2-Dimethylpropanoic acid's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). 2,2-Dimethylpropanoic acid is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.50 mm Hg(3). |
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| UN-Transportnummer | 3261 |
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| Gefahrenklasse | 8 |
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| Verpackungsgruppe | II |
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